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OBJECTIVE: To probe into the efficacy of ligustrazine hydrochloride in treatment of coronary heart disease (CHD). METHODS: 60 patients with CHD admitted into Jiangxi Wuyuan County Traditional Chinese Medicine Hospital from Jan. 2016 to Jan. 2018 were retrospectively selected and divided into two groups according to different therapeutic regimens, the control group (30 cases) was given conventional therapy, the observation group (30 cases) was added ligustrazine hydrochloride. Differences in attack frequencies and durations of angina pectoris, the usage amounts of nitroglycerin, effective rates of electrocardiogram (ECG) and hemorheological indices between two groups were compared. RESULTS: After treatment, the usage amount of nitroglycerin, attack times and attack frequencies of angina pectoris of both groups had been significantly improved, and those of the observation group were significantly better than the control group, with statistically significant differences (P <0.05); the total effective rate of ECG of observation group was 90.00% (27/30), which was significantly higher than that of the control group (66.67%, 20/30), with statistically significant difference (P < 0.05); after treatment, the platelet aggregates ratios, whole blood viscosity high shear, whole blood viscosity low shear, plasma viscosity, hematocrit and fibrinogen levels of the observation group were significantly lower than the control group, with statistically significant differences (P <0.05). CONCLUSION: Ligustrazine hydrochloride can effectively alleviate symptoms of coronary heart disease, with remarkable efficacy. [ABSTRACT FROM AUTHOR]