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2. Bone marrow fibroblasts induce expression of PI3K/NF-κB pathway genes and a pro-angiogenic phenotype in CLL cells

Author

Edelmann, J., Klein-Hitpass, L., Carpinteiro, A., Führer, A., Sellmann, L., Stilgenbauer, S., Dührsen, U., and Dürig, J.

Subjects
*GENETIC regulation, *CELL culture, *GENES, *GROWTH factors
Abstract

Abstract: Microarray-based gene expression profiling (GEP) was used to study how stroma modulates the survival of CLL cells in an in vitro coculture model employing the murine fibroblast cell line M2-10B4. CLL cells cultured in direct contact with the stromal layer (STR) showed a significantly better survival than cells cultured in transwell (TW) inserts above the M2-10B4 cells. STR as compared to TW conditions induced a significant up-regulation of PI3K/NF-κB pro-survival pathway genes and mediated a pro-angiogenetic switch in the CLL cells by up-regulation of vascular endothelial growth factor (VEGF) and osteopontin (OPN) and down-regulation of the anti-angiogenetic molecule thrombospondin-1 (TSP-1). [Copyright &y& Elsevier]

Published
2008
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