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Time series data are significant, and are derived from temporal data, which involve real numbers representing values collected regularly over time. Time series have a great impact on many types of data. However, time series have anomalies. We introduce an anomaly detection paradigm called novel matrix profile (NMP) to solve the all-pairs similarity search problem for time series data in the healthcare. The proposed paradigm inherits the features from two state-of-the-art algorithms: Scalable Time series Anytime Matrix Profile (STAMP) and Scalable Time-series Ordered-search Matrix Profile (STOMP). The proposed NMP caches the output in an easy-to-access fashion for single- and multidimensional data. The proposed NMP can be used on large multivariate data sets and generates approximate solutions of high quality in a reasonable time. It is implemented on a Python platform. To determine its effectiveness, it is compared with the state-of-the-art matrix profile algorithms, i.e., STAMP and STOMP. The results confirm that the proposed NMP provides higher accuracy than the compared algorithms. more...