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Start Over Author "Orlovskiĭ AA" Topic cocarcinogenesis
3 results on '"Orlovskiĭ AA"'

1. [The effect of peripheral cholinergic blockers on the cocarcinogenic action of an experimental influenza infection].

Author

Orlovskiĭ AA, Zalesskiĭ VN, and Smelkova MI

Subjects
Animals, Chronic Disease, Dose-Response Relationship, Drug, Female, Lung drug effects, Lung pathology, Lung Neoplasms pathology, Mammary Glands, Animal drug effects, Mammary Glands, Animal pathology, Mammary Neoplasms, Experimental pathology, Mice, Mice, Inbred C3H, Orthomyxoviridae Infections pathology, Receptors, Muscarinic drug effects, Time Factors, Cocarcinogenesis, Influenza A virus, Lung Neoplasms etiology, Mammary Neoplasms, Experimental etiology, Orthomyxoviridae Infections complications, Parasympatholytics pharmacology
Abstract

The cocarcinogenic effect of chronic influenza infection was shown to be mediated by M-cholinergic structures. Administration of a M-anticholinergic agent in low dose at the key stages of chronic influenza infection development was followed by a nearly complete suppression of its cocarcinogenic action. N-anticholinergic agents failed to exert such effect.

Published
1992

2. [Development of lung tumors in BALB/c mice in chronic influenza infection and inhalation of metal-containing aerosols].

Author

Shevchenko IN, Orlovskiĭ AA, and Struk VI

Subjects
Aerosols, Animals, Chronic Disease, Lung Neoplasms pathology, Male, Mice, Mice, Inbred BALB C, Cocarcinogenesis, Lung Neoplasms etiology, Metals toxicity, Orthomyxoviridae Infections complications
Abstract

Intensification of cocarcinogenic effect of chronic influenza infection (10 months after virus instillation) in BALB/c mice was obtained by polymetallic aerosol inhalation 5 or 6 months after infection. An increase of malignant neoplasms incidence was accompanied by a decrease of the cytoproliferative activity in the thymus and spleen. The immunopathogenic and cocarcinogenic effects were maximal when the aerosol treatment was carried out 6 months after infection.

Published
1987

3. [Secondary intensification of influenza virus reproduction and the development of tumors in mice].

Author

Orlovskiĭ AA, Shevchenko IN, and Struk VI

Subjects
Aerosols, Animals, Chronic Disease, Electron Spin Resonance Spectroscopy, Liver analysis, Liver pathology, Lung analysis, Lung pathology, Lung Neoplasms analysis, Lung Neoplasms pathology, Metals administration & dosage, Mice, Mice, Inbred BALB C, Orthomyxoviridae Infections complications, Time Factors, Cocarcinogenesis, Influenza A virus physiology, Lung Neoplasms etiology, Virus Replication
Abstract

Tumor disposition in mice with chronic influenza infection was shown to be completed chiefly during secondary increase in viral reproduction. This condition presents with various systemic disorders and a pronounced increase in susceptibility to the cocarcinogenic effect of polymetal aerosols.

Published
1989

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