1. Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease
- Author
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Martínez-Horta, Saul, Bejr-Kasem, Helena, Horta-Barba, Andrea, Pascual-Sedano, Berta, Santos-García, Diego, de Deus-Fonticoba, Teresa, Jesús, Silvia, Aguilar, Miquel, Planellas, Lluis, García-Caldentey, Juan, Caballol, Nuria, Vives-Pastor, Bárbara, Hernández-Vara, Jorge, Cabo-Lopez, Iria, López-Manzanares, Lydia, González-Aramburu, Isabel, Ávila-Rivera, Maria Asunción, Catalán, Maria Jose, López-Díaz, Luis Manuel, Puente, Victor, García-Moreno, Jose Manuel, Borrué, Carmen, Solano-Vila, Berta, Álvarez-Sauco, Maria, Vela, Lydia, Escalante, Sonia, Cubo, Esther, Carrillo-Padilla, Francisco, Martínez-Castrillo, Juan Carlos, Sánchez-Alonso, Pilar, Alonso-Losada, Maria Gema, López-Ariztegui, Nuria, Gastón, Itziar, Blázquez-Estrada, Marta, Seijo-Martínez, Manual, Rúiz-Martínez, Javier, Valero-Merino, Caridad, Kurtis, Monica, de Fábregues-Boixar, Oriol, González-Ardura, Jessica, Prieto-Jurczynska, Cristina, Martinez-Martin, Pablo, Mir, Pablo, Kulisevsky, Jaime, COPPADIS Study Group, Fundación Curemos el Parkinson, Curemos el Párkinson, Institut Català de la Salut, [Martínez-Horta S, Bejr-Kasem H, Horta-Barba A, Pascual-Sedano B] Movement Disorders Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain. Centro de Investigación en Red-Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. [Santos-García D] CHUAC, Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain. [de Deus Fonticoba T] Complejo Hospitalario Universitario de Ferrol (CHUF), Ferrol, A Coruña, Spain. [Hernández Vara J, de Fábregues O ] Servei de Neurologia, Grup de Recerca en Malalties Neurodegeneratives, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Solano-Vila B] Hospital Universitari de Girona Doctor Josep Trueta, Institut Català de la Salut (ICS), Girona, Spain. Hospital Santa Caterina, Institut d’Assistència Sanitària (IAS), Salt, Spain, and Hospital Universitari de Girona Dr Josep Trueta
- Subjects
Estils de vida ,Cognition disorders ,Risk factors in diseases ,Parkinson's disease ,Lifestyles ,Coppadis ,Neuropsychological Tests ,Trastorns de la cognició ,PD-MCI ,Clinical trials ,PD‑MCI ,Cognition ,enfermedades del sistema nervioso::enfermedades del sistema nervioso::enfermedades del sistema nervioso::enfermedades neurodegenerativas::enfermedad de Parkinson [ENFERMEDADES] ,fenómenos psicológicos::procesos mentales::cognición [PSIQUIATRÍA Y PSICOLOGÍA] ,Malaltia de Parkinson ,mental disorders ,Humans ,Cognitive Dysfunction ,Parkinson, Malaltia de ,Behavior and Behavior Mechanisms::Psychology, Social::Life Style [PSYCHIATRY AND PSYCHOLOGY] ,RC346-429 ,Life Style ,conducta y mecanismos de la conducta::psicología social::estilo de vida [PSIQUIATRÍA Y PSICOLOGÍA] ,Factors de risc en les malalties ,Research ,Psychological Phenomena::Mental Processes::Cognition [PSYCHIATRY AND PSYCHOLOGY] ,Parkinson Disease ,General Medicine ,Nervous System Diseases::Nervous System Diseases::Nervous System Diseases::Neurodegenerative Diseases::Parkinson Disease [DISEASES] ,Lifestyle ,nervous system diseases ,Cognició ,Parkinson’s disease ,Dementia ,Neurology. Diseases of the nervous system ,Neurology (clinical) ,Assaigs clínics - Abstract
COPPADIS Study Group., [Background] Identifying modifiable risk factors for cognitive impairment in the early stages of Parkinson’s disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials., [Methods] Using a standard approach for the assessment of global cognition in PD and controlling for the effects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, metabolic variables and lifestyle variables in 533 PD participants from the COPPADIS study., [Results] Among the overall sample, 21% of participants were classified as PD-MCI (n = 114) and 4% as PDD (n = 26). The prevalence of hypertension, diabetes and dyslipidemia was significantly higher in cognitively impaired patients while no between-group differences were found for smoking, alcohol intake or use of supplementary vitamins. Better cognitive scores were significantly associated with regular physical exercise (p, [Conclusions] We extend previous findings regarding the positive and negative influence of various comorbidities and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentially modifiable variables with the intention of exploring the possible improvement of the global cognitive status of patients with PD., Fundación Curemos el Parkinson (https://curemoselparkinson.org/) covered the expenses derived from hiring a CRO and from carrying out complementary tests.
- Published
- 2021