7 results on '"Julvez, Jordi"'
Search Results
2. Effect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4-5 y of age: the prospective birth cohort Infancia y Medio Ambiente (INMA) study.
- Author
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Valera-Gran, Desirée, Navarrete-Muñoz, Eva M., Garcia de la Hera, Manuela, Fernández-Somoano, Ana, Tardón, Adonina, Ibarluzea, Jesús, Balluerka, Nekane, Murcia, Mario, González-Safont, Llúcia, Romaguera, Dora, Julvez, Jordi, and Vioque, Jesús
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FOLIC acid in human nutrition ,PEDIATRIC neuropsychology ,MOTHER-child relationship ,NEURAL development ,COGNITIVE development research ,DEVELOPMENTAL neurobiology ,COHORT analysis ,COGNITION in children ,CHILD development ,DATE of conception ,CONFIDENCE intervals ,FOLIC acid ,INTERVIEWING ,LANGUAGE acquisition ,LONGITUDINAL method ,NEUROPSYCHOLOGICAL tests ,MEDICAL cooperation ,MEMORY in children ,META-analysis ,MOTHERS ,NEUROPSYCHOLOGY ,NUTRITIONAL assessment ,NUTRITION policy ,NUTRITIONAL requirements ,QUESTIONNAIRES ,RESEARCH ,RESEARCH evaluation ,EVIDENCE-based medicine ,PROFESSIONAL practice ,MULTIPLE regression analysis ,PREGNANCY - Abstract
Background: The benefits of the use of folic acid supplements (FASs) during the periconception period to prevent neural tube defects and to ensure normal brain development in offspring are well known. There is concern, however, about the long-term effects of the maternal use of high dosages of FASs that exceed the Tolerable Upper Intake Level (UL) (≥1000 µg/d) on child neurocognitive outcomes. Objective: The objective of the study was to examine the association between the use of high dosages of FASs during pregnancy and child neuropsychological development at ages 4-5 y. Design: The multicenter prospective mother-child cohort study, the Infancia y Medio Ambiente (INMA) Project, was conducted in 4 regions of Spain: Asturias, Sabadell, Gipuzkoa, and Valencia. Pregnant women were recruited between 2003 and 2008. Data on 1682 mother-child pairs were included in the final analyses. The pregnant women completed an interviewer-administered questionnaire that was validated to estimate typical dietary folate intake and the use of FASs at 10-13 and 28-32 wk of gestation. Neuropsychological development scores at 4-5 y of age were estimated with the use of the McCarthy Scales of Children's Abilities. Multiple linear regression and meta-analysis were used to obtain combined-effect estimates. Results: During the periconception period, one-third of the women (n = 502) took FAS dosages ≥1000 μg/d. The use of FAS dosages ≥1000 µg/d in this period was negatively associated with several neuropsychological outcomes scores in children: global verbal (β = -2.49; 95% CI: -4.71, -0.27), verbal memory (β = -3.59; 95% CI: -6.95, -0.23), cognitive function of posterior cortex (β = -2.31; 95% CI: -4.45, -0.18), and cognitive function of left posterior cortex (β = -3.26; 95% CI: -5.51, -1.01). Conclusions: The use of FAS dosages exceeding the UL (≥1000 µg/d) during the periconception period was associated with lower levels of cognitive development in children aged 4-5 y. The use of FAS dosages ≥1000 µg/d during pregnancy should be monitored and prevented as much as possible, unless medically prescribed. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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3. Maternal Consumption of Seafood in Pregnancy and Child Neuropsychological Development: A Longitudinal Study Based on a Population With High Consumption Levels.
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Julvez, Jordi, Méndez, Michelle, Fernandez-Barres, Silvia, Romaguera, Dora, Vioque, Jesus, Llop, Sabrina, Ibarluzea, Jesus, Guxens, Monica, Avella-Garcia, Claudia, Tardón, Adonina, Riaño, Isolina, Andiarena, Ainara, Robinson, Oliver, Arija, Victoria, Esnaola, Mikel, Ballester, Ferran, and Sunyer, Jordi
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AUTISM , *CHILD development , *COGNITION in children , *CONFIDENCE intervals , *FOOD habits , *MOTHERHOOD , *NEUROPSYCHOLOGY , *PARENTING , *RESEARCH funding , *SEAFOOD , *DATA analysis software , *DESCRIPTIVE statistics , *ODDS ratio , *SYMPTOMS - Abstract
Seafood consumption during pregnancy is thought to be beneficial for child neuropsychological development, but to our knowledge no large cohort studies with high fatty fish consumption have analyzed the association by seafood subtype. We evaluated 1,892 and 1,589 mother-child pairs at the ages of 14 months and 5 years, respectively, in a population-based Spanish birth cohort established during 2004-2008. Bayley and McCarthy scales and the Childhood Asperger Syndrome Test were used to assess neuropsychological development. Results from multivariate linear regression models were adjusted for sociodemographic characteristics and further adjusted for umbilical cord blood mercury or long-chain polyunsaturated fatty acid concentrations. Overall, consumption of seafood above the recommended limit of 340 g/week was associated with 10-g/week increments in neuropsychological scores. By subtype, in addition to lean fish, consumption of large fatty fish showed a positive association; offspring of persons within the highest quantile (>238 g/week) had an adjusted increase of 2.29 points in McCarthy general cognitive score (95% confidence interval: 0.42, 4.16). Similar findings were observed for the Childhood Asperger Syndrome Test. Beta coefficients diminished 15%-30% after adjustment for mercury or long-chain polyunsaturated fatty acid concentrations. Consumption of large fatty fish during pregnancy presents moderate child neuropsychological benefits, including improvements in cognitive functioning and some protection from autism-spectrum traits. [ABSTRACT FROM AUTHOR]
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- 2016
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4. Association between Child Cortisol Levels in Saliva and Neuropsychological Development during the Second Year of Life.
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Forns, Joan, Vegas, Oscar, Julvez, Jordi, Garcia‐Esteban, Raquel, Rivera, Marcela, Lertxundi, Nerea, Guxens, Mònica, Fano, Eduardo, Ferrer, Muriel, Grellier, James, Ibarluzea, Jesús, and Sunyer, Jordi
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SALIVA analysis ,BREASTFEEDING ,CHILD psychology ,COGNITION ,COGNITION in children ,STATISTICAL correlation ,ENZYME-linked immunosorbent assay ,HYDROCORTISONE ,INFANT development ,NEUROPSYCHOLOGICAL tests ,MOTHERS ,PSYCHOLOGY of movement ,QUESTIONNAIRES ,SOCIAL context ,INTER-observer reliability ,DATA analysis software ,CHILDREN - Abstract
Exposure to highly elevated levels of cortisol has been linked with impairments in cognitive capacities in both children and adults. By contrast, moderate levels of cortisol may engender beneficial effects. The main aim of this study was to assess the association between child cortisol levels and neuropsychological development during the second year of life. A population-based birth cohort was established in the city of Sabadell (Catalonia, Spain) as part of the INMA (Environment and Childhood) Project. We assessed the cognitive and psychomotor development at the age of 14 months using the Bayley Scales of Infant Development (BSID). We included 302 children assessed during their second year of life for whom we had information on neuropsychological assessment and measurements of cortisol in saliva. Higher levels of cortisol were associated with better scores in BSID's mental scale. There was no association between cortisol levels and psychomotor test scores. We found a small positive association between duration of breastfeeding and child cortisol levels. This association was only found in boys. The results of this study suggest that moderate levels of cortisol in children could have small beneficial effects on their early neuropsychological development. Copyright © 2013 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
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- 2014
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5. Association of ADHD symptoms and social competence with cognitive status in preschoolers.
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Ramos, Rosa, Freire, Carmen, Julvez, Jordi, Fernández, Mariana, García-Esteban, Raquel, Torrent, Maties, Sunyer, Jordi, and Olea, Nicolás
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ANALYSIS of variance ,ATTENTION-deficit hyperactivity disorder ,CHI-squared test ,COGNITION in children ,STATISTICAL correlation ,FACTOR analysis ,RESEARCH funding ,SCALES (Weighing instruments) ,T-test (Statistics) ,SOCIAL disabilities ,BEHAVIOR disorders ,INTER-observer reliability ,CROSS-sectional method ,DATA analysis software ,DESCRIPTIVE statistics ,DISEASE complications ,SYMPTOMS - Abstract
We aimed to investigate the association of attention-deficit hyperactivity disorder (ADHD) symptoms and social competence outcomes with cognitive status in preschool children. The study population was drawn from three birth cohorts belonging to the Spanish INMA ( Infancia y Medio Ambiente) project: Menorca ( n = 289), Ribera d'Ebre ( n = 60), and Granada ( n = 108). Children were assessed at the age of 4 years for cognitive functions (McCarthy Scales of Children's Abilities, MSCA) by psychologists and for inattention and hyperactivity symptoms (ADHD Criteria of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, ADHD-DSM-IV) and social competence (California Preschool Social Competence Scale) by their teachers. Multiple regression analyses were conducted to examine potential associations between behavioral outcomes (ADHD symptoms and social competence) and MSCA cognitive outcomes, adjusting for confounders. The presence of general ADHD symptoms (inattention, hyperactivity, or both) and poorer social competence both showed negative associations with cognitive outcomes. When we compared children according to ADHD subtypes, those with inattention symptoms alone and those with both inattention and hyperactivity symptoms showed significantly lower cognitive function scores in comparison to children with no ADHD symptoms. Behavioral dysfunctions in preschoolers may be associated with impairment of cognitive functions. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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6. Genetic Variants of the FADS Gene Cluster and ELOVL Gene Family, Colostrums LC-PUFA Levels, Breastfeeding, and Child Cognition.
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Morales, Eva, Bustamante, Mariona, Gonzalez, Juan Ramon, Guxens, Monica, Torrent, Maties, Mendez, Michelle, Garcia-Esteban, Raquel, Julvez, Jordi, Forns, Joan, Vrijheid, Martine, Molto-Puigmarti, Carolina, Lopez-Sabater, Carmen, Estivill, Xavier, and Jordi Sunyer
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MAMMARY gland secretions ,COGNITION in children ,BREASTFEEDING ,BREAST milk ,PREGNANT women ,INFANT development ,BAYLEY Scales of Infant Development - Abstract
Introduction: Breastfeeding effects on cognition are attributed to long-chain polyunsaturated fatty acids (LC-PUFAs), but controversy persists. Genetic variation in fatty acid desaturase (FADS) and elongase (ELOVL) enzymes has been overlooked when studying the effects of LC-PUFAs supply on cognition. We aimed to: 1) to determine whether maternal genetic variants in the FADS cluster and ELOVL genes contribute to differences in LC-PUFA levels in colostrum; 2) to analyze whether these maternal variants are related to child cognition; and 3) to assess whether children's variants modify breastfeeding effects on cognition. Methods: Data come from two population-based birth cohorts (n = 400 mother-child pairs from INMA-Sabadell; and n = 340 children from INMA-Menorca). LC-PUFAs were measured in 270 colostrum samples from INMA-Sabadell. Tag SNPs were genotyped both in mothers and children (13 in the FADS cluster, 6 in ELOVL2, and 7 in ELOVL5). Child cognition was assessed at 14 mo and 4 y using the Bayley Scales of Infant Development and the McCarthy Scales of Children's Abilities, respectively. Results: Children of mothers carrying genetic variants associated with lower FADS1 activity (regulating AA and EPA synthesis), higher FADS2 activity (regulating DHA synthesis), and with higher EPA/AA and DHA/AA ratios in colostrum showed a significant advantage in cognition at 14 mo (3.5 to 5.3 points). Not being breastfed conferred an 8- to 9-point disadvantage in cognition among children GG homozygote for rs174468 (low FADS1 activity) but not among those with the A allele. Moreover, not being breastfed resulted in a disadvantage in cognition (5 to 8 points) among children CC homozygote for rs2397142 (low ELOVL5 activity), but not among those carrying the G allele. Conclusion: Genetically determined maternal supplies of LC-PUFAs during pregnancy and lactation appear to be crucial for child cognition. Breastfeeding effects on cognition are modified by child genetic variation in fatty acid desaturase and elongase enzymes. [ABSTRACT FROM AUTHOR]
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- 2011
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7. Association of Early-life Exposure to Household Gas Appliances and Indoor Nitrogen Dioxide With Cognition and Attention Behavior in Preschoolers.
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Morales, Eva, Julvez, Jordi, Torrent, Maties, de Cid, Rafael, Guxens, Mònica, Bustamante, Mariona, Künzli, Nino, and Sunyer, Jordi
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NITROGEN dioxide , *INDOOR air pollution , *GAS appliances , *HOUSEHOLD appliances , *PRESCHOOL children , *COGNITION in children , *NEUROPSYCHOLOGY , *GENETIC polymorphisms , *GLUTATHIONE transferase - Abstract
The authors investigated the association of early-life exposure to indoor air pollution with neuropsychological development in preschoolers and assessed whether this association differs by glutathione-S-transferase gene (GSTP1) polymorphisms. A prospective, population-based birth cohort was set up in Menorca, Spain, in 1997â1999 (nâ=â482). Children were assessed for cognitive functioning (McCarthy Scales of Childrens Abilities) and attention-hyperactivity behaviors (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) at age 4 years. During the first 3 months of life, information about gas appliances at home and indoor nitrogen dioxide concentration was collected at each participants home (nâ=â398, 83%). Genotyping was conducted for the GSTP1 coding variant Ile105Val. Use of gas appliances was inversely associated with cognitive outcomes (β coefficient for general cognitionâ=ââ5.10, 95% confidence interval (CI): â9.92, â0.28; odds ratio for inattention symptomsâ=â3.59, 95% CI: 1.14, 11.33), independent of social class and other confounders. Nitrogen dioxide concentrations were associated with cognitive function (a decrease of 0.27 point per 1 ppb, 95% CI: â0.48, â0.07) and inattention symptoms (odds ratioâ=â1.06, 95% CI: 1.01, 1.12). The deleterious effect of indoor pollution from gas appliances on neuropsychological outcomes was stronger in children with the GSTP1 Val-105 allele. Early-life exposure to air pollution from indoor gas appliances may be negatively associated with neuropsychological development through the first 4 years of life, particularly among genetically susceptible children. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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