6 results on '"Yu, Hong-zhao"'
Search Results
2. Phytosterol intake and overall survival in newly diagnosed ovarian cancer patients: An ambispective cohort study
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Jun-Qi Zhao, Ying-Ying Hao, Ting-Ting Gong, Yi-Fan Wei, Gang Zheng, Zong-Da Du, Bing-Jie Zou, Shi Yan, Fang-Hua Liu, Song Gao, Qi-Jun Wu, and Yu-Hong Zhao
- Subjects
cohort ,diet ,ovarian cancer ,phytosterol ,survival ,Nutrition. Foods and food supply ,TX341-641 - Abstract
BackgroundPhytosterol is a bioactive compound existing in all plant foods, which might have anticancer properties. The aim of this study was to first assess the impact of the pre-diagnosis phytosterol intake on overall survival (OS) of patients with ovarian cancer (OC).Materials and methodsThis ambispective cohort study recruited 703 newly diagnosed OC patients to investigate the aforementioned associations. Dietary intake was assessed using a validated 111-item food frequency questionnaire. Deaths were ascertained until March 31, 2021, through active follow-up and medical records. Cox proportional hazards regression models were applied to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsDuring the median follow-up of 37.17 months, 130 deaths occurred. The median age at diagnosis of 703 OC patients was 53.00 (interquartile: 48.00–60.00) years. Of these, almost half patients (48.08%) were diagnosed in advanced International Federation of Gynecology and Obstetrics (FIGO) stage (III-IV). Additionally, more than half patients were serous carcinoma (68.14%), poorly differentiated (85.21%), and no residual lesions (78.66%). Patients consumed the highest tertile of dietary campesterol (HR = 0.54, 95% CI = 0.31–0.94, P trend < 0.05), stigmasterol (HR = 0.60, 95% CI = 0.37–0.98), and β-sitosterol (HR = 0.63, 95% CI = 0.40–0.99) were significantly associated with better OS compared with those with the lowest tertile of intake. The curvilinear associations were observed between total phytosterols and β-sitosterol intake and OC survival (P non-linear < 0.05). Significant associations were generally consistent across different subgroups stratified by demographical, clinical, and immunohistochemical characteristics. Moreover, there were significant interactions between phytosterol intake and age at diagnosis, body mass index, as well as expressions of Wilms’ tumor-1 and Progestogen Receptor (all P interaction < 0.05).ConclusionPre-diagnosis higher campesterol, stigmasterol, and β-sitosterol intake were associated with better survival among OC patients.
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- 2022
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3. Pre-diagnosis Dietary One-Carbon Metabolism Micronutrients Consumption and Ovarian Cancer Survival: A Prospective Cohort Study
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He-Li Xu, Ting-Ting Gong, Fang-Hua Liu, Yi-Fan Wei, Hong-Yu Chen, Shi Yan, Yu-Hong Zhao, Song Gao, Yi-Sheng Jiao, and Qi-Jun Wu
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cohort ,diet ,one-carbon metabolism ,ovarian cancer ,survival ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Background and AimsEpidemiological evidence on the relation between one-carbon metabolism (OCM) micronutrients intake and ovarian cancer (OC) survival are limited and conflicting. We evaluated the aforementioned associations in a prospective cohort-the Ovarian Cancer Follow-Up Study.MethodsA total of 635 newly diagnosed OC patients aged 18–79 y were enrolled in the present study. Dietary intake related to one-carbon metabolism, including methionine, vitamins B2, B3, B6, B9, B12, choline, and betaine, was assessed using a validated 111-item food frequency questionnaire. Deaths were ascertained until March 31, 2021, via medical records and active follow-up. Cox proportional hazards regression model was used to evaluate the hazard ratios (HRs) and 95% confidence intervals (CIs) for these aforementioned associations.ResultsDuring a median follow-up of 37.2 months (interquartile: 24.7–50.2 months), 114 deaths were identified. We observed an improved survival with the highest compared with the lowest tertile of dietary vitamin B6 (HR = 0.52, 95%CI: 0.32–0.84, P-trend
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- 2022
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4. Prediagnosis Depression Rather Than Anxiety Symptoms Is Associated with Decreased Ovarian Cancer Survival: Findings from the Ovarian Cancer Follow-Up Study (OOPS)
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Yi-Zi Li, Xue Qin, Fang-Hua Liu, Wen-Xiao Chen, Yi-Fan Wei, Na Wang, Shi Yan, Ye Kang, Yu-Hong Zhao, Song Gao, Ting-Ting Gong, and Qi-Jun Wu
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anxiety ,cohort ,depression ,ovarian cancer ,survival ,Medicine - Abstract
Background: The relationship between prediagnosis depression, anxiety symptoms, and ovarian cancer (OC) survival is unknown. We aimed to explore these associations to provide further epidemiological evidence. Methods: We investigated the relationship between prediagnosis depression, anxiety symptoms, and OC survival in a prospective cohort study of newly diagnosed OC patients aged 18–79 years. Depression and anxiety symptoms were assessed using the Patient Health Questionnaire 9 and Generalized Anxiety Disorder 7 at diagnosis, respectively. Deaths were ascertained until 31 March 2021 via medical records and active follow-up. Multivariable-adjusted Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) with prediagnosis depression and anxiety symptoms and all-cause mortality of OC. Results: We found 56 (9.4%) and 235 (39.3%) OC patients with depression and anxiety symptoms, respectively. During a median follow-up of 37.2 months (interquartile range 24.7–50.2 months), 130 deaths were confirmed. Compared with non-depression symptoms, patients with prediagnosis depressive symptoms showed a significantly increased risk of OC mortality (HR = 2.10, 95% CI: 1.20–3.70). Of note, the association was still robust when focusing on the OC patients with severe depressive symptoms (HR = 2.10, 95% CI: 1.07–4.12). However, we observed no association between prediagnosis anxiety symptoms of different severity and OC mortality. Interestingly, OC patients with combined moderate depression and anxiety symptoms had a significantly increased risk of OC mortality (HR = 3.23, 95% CI: 1.14–9.11) compared to those with no symptoms of depression and anxiety. Notably, Wilms’s tumor 1 was significantly associated with depression and anxiety symptoms (p < 0.05). Conclusions: Prediagnosis depression increases the risk of OC mortality. Large multicenter studies are required to confirm this finding.
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- 2022
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5. Pre-diagnosis Cruciferous Vegetables and Isothiocyanates Intake and Ovarian Cancer Survival: A Prospective Cohort Study
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Yi-Fan Wei, Ying-Ying Hao, Song Gao, Xiu-Qin Li, Fang-Hua Liu, Zhao-Yan Wen, Han-Yuan Wang, Shuang Zhang, Shi Yan, Meng Luan, Yu-Hong Zhao, Ting-Ting Gong, and Qi-Jun Wu
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cohort ,cruciferous vegetables ,isothiocyanates ,ovarian cancer ,prognosis ,survival ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Background: The associations of the consumption of cruciferous vegetables (CVs) and their bioactive components, isothiocyanates (ITCs), with ovarian cancer (OC) mortality have been unclear, owing to limited studies and inconsistent findings. To date, no studies have evaluated these associations among Chinese patients with OC. This study aims to provide more evidence indicating the relationships of pre-diagnosis CVs and ITC intake with OC survival.Methods: We examined the associations of pre-diagnosis CV and ITC intake with OC mortality in a hospital-based cohort (n = 853) of Chinese patients with epithelial OC between 2015 and 2020. Pre-diagnosis dietary information was evaluated with a validated food frequency questionnaire. Deaths were ascertained until March 31, 2021 via medical records and active follow-up. The associations were examined with the Cox proportional hazards model, adjusted for potential confounders, and stratified by menopausal status, residual lesions, histological type, and body mass index (BMI).Results: During a median follow-up of 37.2 months (interquartile: 24.7–50.2 months), we observed 130 deaths. The highest tertile of total CV intake was associated with better survival than the lowest tertile intake [hazard ratio (HR) = 0.57, 95% confidence interval (CI) = 0.33–0.98, p trend < 0.05]. In addition, higher intake of ITCs from CVs was associated with better survival (HRT3VS.T1 = 0.59, 95% CI = 0.36–0.99, p trend = 0.06). Significant inverse associations were also observed for subgroup analyses stratified by menopausal status, residual lesions, histological type, and BMI, although not all associations showed statistical significance.Conclusion: Increasing pre-diagnosis consumption of CVs and ITCs was strongly associated with better survival in patients with OC.
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- 2021
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6. Relationship between legume consumption and metabolic syndrome: A systematic review and meta-analysis of observational studies
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Yu-Ting Jiang, Yashu Liu, Qing Chang, Yu-Hong Zhao, Jia-Yu Zhang, and Qi-Jun Wu
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Adult ,Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Medicine (miscellaneous) ,030209 endocrinology & metabolism ,Subgroup analysis ,030204 cardiovascular system & hematology ,Recommended Dietary Allowances ,Risk Assessment ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Prevalence ,medicine ,Humans ,Aged ,Metabolic Syndrome ,Nutrition and Dietetics ,business.industry ,Confounding ,Fabaceae ,Odds ratio ,Publication bias ,Middle Aged ,Protective Factors ,Observational Studies as Topic ,Meta-analysis ,Cohort ,Female ,Observational study ,Diet, Healthy ,Cardiology and Cardiovascular Medicine ,business ,Nutritive Value ,Risk Reduction Behavior ,Cohort study - Abstract
Aims The prevalence of metabolic syndrome (MetS) has been increasing in recent years. Investigation of whether consumption of legumes as a part of healthy diet could reduce the odds of MetS has led to inconsistent conclusions. Here, we performed the first meta-analysis of observational studies to analyze the association between legume consumption and prevalence of MetS. Data synthesis PubMed, EMBASE and Web of Science databases were searched to identify observational studies up to 1st June, 2019. We extracted data from the studies included and performed quality assessments. Summary odds ratio (OR) with 95% confidence intervals (CI) were calculated using a random-effects model. Publication bias, subgroup and sensitivity analyses were also performed. Results We finally included four cross-sectional, two cohort and one case-control study involving 56,028 participants. The summary OR revealed no statistically significant association between legume consumption and odds of MetS (OR = 0.93, 95% CI = 0.76-1.12, I2 = 73.5%). Subgroup analysis of study characteristics and adjustment for confounding along with sensitivity analyses revealed no statistically significant differences. No evidence of publication bias was detected. Conclusion Legume consumption is not associated with odds of MetS. These findings require validation in well-designed cohort studies and randomized clinical trials with accurate measurement of legume intake and strict control of confounders. Registration This study was registered with the International Prospective Register of Systematic Reviews (registration number: CRD42019131777).
- Published
- 2020
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