1. Anti-TNF-A Therapy about Infliximab and Adalimamab for the Effectiveness in Ulcerative Colitis Compared with Conventional Therapy: A Meta-Analysis.
- Author
-
Zhou Z, Dai C, and Liu WX
- Subjects
- Aminosalicylic Acids therapeutic use, Azathioprine therapeutic use, Colectomy statistics & numerical data, Colitis, Ulcerative surgery, Glucocorticoids therapeutic use, Humans, Immunosuppressive Agents therapeutic use, Mercaptopurine therapeutic use, Remission Induction, Adalimumab therapeutic use, Colitis, Ulcerative drug therapy, Gastrointestinal Agents therapeutic use, Infliximab therapeutic use, Tumor Necrosis Factor-alpha antagonists & inhibitors
- Abstract
Background/aims: TNF-α has an important role in the pathogenesis of ulcerative colitis (UC). It seems that anti-TNF-α therapy is beneficial in the treatment of UC. The aim was to assess the effectiveness of Infliximab and Adalimamab with UC compared with con- ventional therapy., Methodology: The Pubmed and Embase databases were searched for studies investigating the efficacy of infliximab and adalimumab on UC., Results: Infliximab had a statistically significant effects in induction of clinical response (RR = 1.67; 95% CI 1.12 to 2.50) of UC compared with conventional therapy, but those had not a statistically significant effects in clinical remission (RR = 1.63; 95% CI 0.84 to 3.18) and reduction of colectomy rate (RR = 0.54; 95% CI 0.26 to 1.12) of UC. And adalimumab had a statistically significant effects in induction of clinical remission (RR =1.82; 95% CI 1.24 to 2.67) and clinical response (RR =1.36; 95% CI 1.13 to 1.64) of UC compared with conventional therapy., Conclusion: Our meta-analyses suggested that Infliximab had a statistically significant effects in induction of clinical response of UC compared with conventional therapy and adalimumab had a statistically significant effects in induction of clinical remission and clinical response of UC compared with conventional therapy.
- Published
- 2015