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In more than 1000 patients with noncalculous cholecystitis, chronic colitis (nonulcerative, nonspecific ulcerative, Crohn's disease of the bowel) and with dyskinesia of intestine the participation of allergic components was investigated in the development and chronic duration of the diseases. More often was observed the sensibilization to bacteria of conditionally pathogenetic microflora (E. coli, staphylococcus, streptococcus, proteus) that was confirmed by positive skin tests, sensibilization of lymphocytes to microbic allergens, increase of the titer of microbic antibodies in blood. The sensibilization to tissue proteins and subcellular fractions (nucleus, mitochondrias, microsomes) was seldom observed. Autoimmune disorders appeared in patients with nonspecific ulcerative colitis by ascending doses of bacterial allergens of E. coli, proteus, staphylococcus, streptococcus. By means of the study of direct and remote results of specific immunotherapy there was established the dynamic of clinical and laboratory-instrumental indices of the patients state, and of immunologic tests, reflecting the nonspecific factors of defense, microbic and tissue allergy.

Three hundred and fifteen patients with chronic nonulcerative colitis were studied. Two hundred patients were given specific immunotherapy by bacterial allergens, and 115 formed the control group. Immunotherapy was carried out with increasing doses of bacterial allergens - E Coli, Streptococcus, Staphylococcus or Proteus - for 1-2 years. The effectiveness of immunotherapy was established toward the end of the course of treatment (as well as over a long period). The improvement was expressed clinically as a decrease in the endoscopic and coprologic signs of inflammation, an increase in natural immunologic resistance and a reduction of bacterial allergy and autoimmune disorders.