1. Microbial signalling in colonic motility.
- Author
-
Dalziel JE, Spencer NJ, and Young W
- Subjects
- Animals, Bacteria metabolism, Biological Phenomena, Colon innervation, Colon physiology, Gastrointestinal Tract innervation, Humans, Receptors, G-Protein-Coupled metabolism, Sensory Receptor Cells microbiology, Signal Transduction, Colon microbiology, Gastrointestinal Motility, Gastrointestinal Tract microbiology, Gastrointestinal Tract physiology, Sensory Receptor Cells physiology
- Abstract
Sensory nerve endings within the wall of the gastrointestinal (GI) tract may respond to bacterial signalling, providing the basis for key biological processes that underlie intestinal motility and microbial homeostasis. Enteric neurons and smooth muscle cells are well known to express an array of receptors, including G-protein coupled receptors and ligand-gated ion channels, that can sense chemical ligands and other bacterially-derived substances. These include short chain fatty acids, secondary bile acids and lipopolysaccharide. For neural detection of microbial activators to occur, luminal substances must first interact with enterocytes for direct signalling or cross paracellularly. Recent studies indicate that bacterial-derived microvesicles can cross the gut epithelial barrier and affect motility. This suggests a possible intercellular communication pathway between the GI tract and the ENS. We explore the idea that bacterial microvesicles can behave as a delivery package for communication between microbe and host., (Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF