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Your search keyword '"Receptor, EphA6 genetics"' showing total 3 results
Start Over Descriptor "Receptor, EphA6 genetics" Topic colonic neoplasms

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3 results on '"Receptor, EphA6 genetics"'

1. Reply to Ashktorab et al.: Mutational landscape of colon cancers in African Americans.

Author

Guda K, Veigl ML, Varadan V, Nosrati A, Ravi L, Lutterbaugh J, Beard L, Willson JK, Sedwick WD, Wang ZJ, Molyneaux N, Miron A, Adams MD, Elston RC, Markowitz SD, and Willis JE

Subjects
Female, Humans, Male, Black or African American genetics, Colonic Neoplasms ethnology, Colonic Neoplasms genetics, Mutation, Proto-Oncogene Proteins genetics, Receptor, EphA6 genetics, Tumor Suppressor Proteins genetics
Published
2015
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3. Novel recurrently mutated genes in African American colon cancers.

Author

Guda K, Veigl ML, Varadan V, Nosrati A, Ravi L, Lutterbaugh J, Beard L, Willson JK, Sedwick WD, Wang ZJ, Molyneaux N, Miron A, Adams MD, Elston RC, Markowitz SD, and Willis JE

Subjects
Exome, Female, Genome-Wide Association Study, Humans, Male, White People genetics, Black or African American genetics, Colonic Neoplasms ethnology, Colonic Neoplasms genetics, Mutation, Proto-Oncogene Proteins genetics, Receptor, EphA6 genetics, Tumor Suppressor Proteins genetics
Abstract

We used whole-exome and targeted sequencing to characterize somatic mutations in 103 colorectal cancers (CRC) from African Americans, identifying 20 new genes as significantly mutated in CRC. Resequencing 129 Caucasian derived CRCs confirmed a 15-gene set as a preferential target for mutations in African American CRCs. Two predominant genes, ephrin type A receptor 6 (EPHA6) and folliculin (FLCN), with mutations exclusive to African American CRCs, are by genetic and biological criteria highly likely African American CRC driver genes. These previously unsuspected differences in the mutational landscapes of CRCs arising among individuals of different ethnicities have potential to impact on broader disparities in cancer behaviors.

Published
2015
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