1. G-EYE colonoscopy is superior to standard colonoscopy for increasing adenoma detection rate
- Author
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Jakob Hendel, Mati Shnell, Johannes W. Rey, Helmut Neumann, Shmuel Rochberger, Rogier de Ridder, Daniel Teubner, Seth A. Gross, Meir Mizrahi, Alexander Vilkin, Michael Yair, Yuri Brachman, Silvia Sanduleanu-Dascalescu, Armita Armina Abedi, Eran Israeli, Shaul Yaari, John Gásdal Karstensen, Chiara Notaristefano, Beni Shpak, Peter Thielsen, Arthur Hoffman, Harold Jacob, Menachem Moshkowitz, Amit Maliar, D. Nageshwar Reddy, Martin Goetz, Pier Alberto Testoni, Julie Isabelle Plougmann, Trine Stigaard, Dov Abramowich, Hrushikesh Chaudhari, Haim Shirin, Sauid Ishaq, Ariel A. Benson, Peter D. Siersema, Michal Braverman, Edi Viale, Stine Sloth, Tiberiu Hershcovici, Nathan Gluck, Shay Matalon, Roel M M Bogie, Ralf Kiesslich, Amir Waizbard, Eyal Shachar, Peter Vilmann, Mark Pochapin, Roman Simantov, Julia Epshtein, Eduard Tsvang, Interne Geneeskunde, MUMC+: MA Maag Darm Lever (9), Promovendi ODB, MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Shirin, H., Shpak, B., Epshtein, J., Karstensen, J. G., Hoffman, A., de Ridder, R., Testoni, P. A., Ishaq, S., Reddy, D. N., Gross, S. A., Neumann, H., Goetz, M., Abramowich, D., Moshkowitz, M., Mizrahi, M., Vilmann, P., Rey, J. W., Sanduleanu-Dascalescu, S., Viale, E., Chaudhari, H., Pochapin, M. B., Yair, M., Shnell, M., Yaari, S., Hendel, J. W., Teubner, D., Bogie, R. M. M., Notaristefano, C., Simantov, R., Gluck, N., Israeli, E., Stigaard, T., Matalon, S., Vilkin, A., Benson, A., Sloth, S., Maliar, A., Waizbard, A., Jacob, H., Thielsen, P., Shachar, E., Rochberger, S., Hershcovici, T., Plougmann, J. I., Braverman, M., Tsvang, E., Abedi, A. A., Brachman, Y., Siersema, P. D., and Kiesslich, R.
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Male ,Colorectal cancer ,MULTICENTER ,Colonoscopy ,Aftercare ,Colorectal Neoplasm ,Balloon ,law.invention ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,Adenomatous Polyps ,Feces ,Hemoglobins ,0302 clinical medicine ,Randomized controlled trial ,law ,Clinical endpoint ,Early Detection of Cancer ,ENDOCUFF-ASSISTED COLONOSCOPY ,medicine.diagnostic_test ,Colonoscopes ,Incidence (epidemiology) ,Immunochemistry ,Gastroenterology ,Adenomatous Polyp ,Middle Aged ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Female ,Radiology ,Colorectal Neoplasms ,Human ,Adenoma ,medicine.medical_specialty ,Colonic Polyps ,03 medical and health sciences ,COLORECTAL-CANCER INCIDENCE ,SURVEILLANCE ,medicine ,Humans ,INTERVAL ,Radiology, Nuclear Medicine and imaging ,BALLOON COLONOSCOPE ,Hemoglobin ,TANDEM COLONOSCOPY ,Colonoscope ,Aged ,LESIONS ,SOCIETY TASK-FORCE ,business.industry ,medicine.disease ,Clinical trial ,Colonic Polyp ,MISS RATE ,Fece ,business - Abstract
Contains fulltext : 205162.pdf (Publisher’s version ) (Open Access) BACKGROUND AND AIMS: Colorectal cancer (CRC) is largely preventable with routine screening and surveillance colonoscopy; however, interval cancers arising from precancerous lesions missed by standard colonoscopy still occur. An increased adenoma detection rate (ADR) has been found to be inversely associated with interval cancers. The G-EYE device includes a reusable balloon integrated at the distal tip of a standard colonoscope, which flattens haustral folds, centralizes the colonoscope's optics, and reduces bowel slippage. The insufflated balloon also aims to enhance visualization of the colon during withdrawal, thereby increasing the ADR. METHODS: In this randomized, controlled, international, multicenter study (11 centers), patients (aged >/=50 years) referred to colonoscopy for screening, surveillance, or changes in bowel habits were randomized to undergo either balloon-assisted colonoscopy by using an insufflated balloon during withdrawal or standard high-definition colonoscopy. The primary endpoint was the ADR. RESULTS: One thousand patients were enrolled between May 2014 and September 2016 to undergo colonoscopy by experienced endoscopists; 803 were finally analyzed (standard colonoscopy n = 396; balloon-assisted colonoscopy n = 407). Baseline parameters were similar in both groups. Balloon-assisted colonoscopy provided a 48.0% ADR compared with 37.5% in the standard colonoscopy group (28% increase; P = .0027). Additionally, balloon-assisted colonoscopy provided for a significant increase in detection of advanced (P = .0033) flat adenomas (P < .0001) and sessile serrated adenomas/polyps (P = .0026). CONCLUSION: Balloon-assisted colonoscopy yielded a higher ADR and increased the detection of advanced, flat, and sessile serrated adenomas/polyps when compared with standard colonoscopy. Improved detection by the G-EYE device could impact the quality of CRC screening by reducing miss rates and consequently reducing interval cancer incidence. (Clinical trial registration number: NCT01917513.).
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- 2019
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