1. CSF3R mutations have a high degree of overlap with CEBPA mutations in pediatric AML.
- Author
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Maxson, Julia E., Ries, Rhonda E., Yi-Cheng Wang, Gerbing, Robert B., Kolb, E. Anders, Thompson, Sarah L., Guidry Auvil, Jaime M., Marra, Marco A., Yussanne Ma, Zusheng Zong, Mungall, Andrew J., Moore, Richard, Long, William, Gesuwan, Patee, Davidsen, Tanja M., Hermida, Leandro C., Hughes, Seamus B., Farrar, Jason E., Radich, Jerald P., and Smith, Malcolm A.
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COLONY-stimulating factors (Physiology) , *ACUTE myeloid leukemia , *RUNX proteins , *ONCOLOGY , *TREATMENT effectiveness - Abstract
The article presents a study which identified the oncogenic colony-stimulating factor 3 receptor (CSF3R) mutations in pediatric acute myeloid leukemia (AML). Also cited are the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) program by the Children's Oncology Group (COG) and the U.S.' National Institutes of Health National Cancer Institute, and the common genetic alteration in patients with CSF3R like the core binding factor (CBF) abnormalities.
- Published
- 2016
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