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Your search keyword '"Selgrad M"' showing total 8 results
Start Over Author "Selgrad M" Topic colorectal cancer
8 results on '"Selgrad M"'

3. JC Virus Infects the Enteric Glia of Patients with Chronic Idiopathic Intestinal Pseudo-Obstruction

Author

Selgrad M, Fini L, Williams S, Tonini M, Genta RM, Goel A, Boland CR, DE GIORGIO, ROBERTO, COGLIANDRO, ROSANNA FRANCESCA, STANGHELLINI, VINCENZO, BARBARA, GIOVANNI, CORINALDESI, ROBERTO, RICCIARDIELLO, LUIGI, Selgrad M, De Giorgio R, Fini L, Cogliandro R, Williams S, Stanghellini V, Barbara G, Tonini M, Corinaldesi R, Genta RM, Goel A, Boland CR, and Ricciardiello L.

Subjects
COLORECTAL CANCER, LIVER TRANSPLANTATION, jc virus
Published
2008

4. Epigenetic Silencing of Dll1 Regulates Notch Activation in Gastric Cancer

Author

Fini L, Garcia M, Selgrad M, Shin SK, Jascur T, Yao Y, Malfertheiner P, Wex T, Genta RM, Goel A, Sepulveda A, Boland CR, RICCIARDIELLO, LUIGI, Fini L, Garcia M, Selgrad M, Shin SK, Jascur T, Yao Y, Malfertheiner P, Wex T, Genta RM, Goel A, Sepulveda A, Boland CR, and Ricciardiello L.

Subjects
NOTCH, COLORECTAL CANCER, DNA METHYLATION
Published
2008

5. The Role of JC Virus in Colorectal Neoplasia Occurring After Liver Transplantation

Author

Selgrad M, Koornstra JJ, Fini L, Haagsma EB, Blom MR, Dijkstra G, Verdonk RC, de Jong S, Williams S, Meyer RL, Goel A, Boland C.R., RICCIARDIELLO, LUIGI, Selgrad M, Koornstra JJ, Fini L, Haagsma EB, Blom MR, Dijkstra G, Verdonk RC, de Jong S, Williams S, Meyer RL, Goel A, Ricciardiello L, and Boland CR.

Subjects
COLORECTAL CANCER, POLYOMAVIRUS JC INFECTION, LIVER TRANSPLANTATION
Published
2008

6. Association between JC virus and the development of colorectal neoplasia after liver transplantation

Author

Blom M, Selgrad M, de Jong S, Fini L, Dijkstra G, Verdonk RC, Williams S, Meyer R, Goel A, Kleibeuker JH, Haagsma EB, Boland CR, Koornstra J.J., RICCIARDIELLO, LUIGI, Blom M, Selgrad M, de Jong S, Fini L, Dijkstra G, Verdonk RC, Williams S, Meyer R, Goel A, Kleibeuker JH, Haagsma EB, Ricciardiello L, Boland CR, and Koornstra JJ.

Subjects
COLORECTAL CANCER, jc viru, LIVER TRANSPLANTATION
Published
2008

8. JC Virus Infection in Colorectal Neoplasia That Develops after Liver Transplantation

Author

Edward B. DeVol, C. Richard Boland, Elizabeth B. Haagsma, Robert C. Verdonk, Lucia Fini, Wytske Boersma-van Ek, Luigi Ricciardiello, Gerard Dijkstra, S Williams, Rong Huang, Ajay Goel, Jan J. Koornstra, Steven de Jong, Michael Selgrad, R Meyer, M. Blom, Selgrad M., Koornstra J.J., Fini L., Blom M., Huang R., Devol E.B., Boersma-van Ek.W., Dijkstra G., Verdonk R.C., de Jong S., Goel A., Williams S.L., Meyer R.L., Haagsma E.B., Ricciardiello L., Boland C.R., Guided Treatment in Optimal Selected Cancer Patients (GUTS), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Targeted Gynaecologic Oncology (TARGON), Translational Immunology Groningen (TRIGR), and Groningen Institute for Organ Transplantation (GIOT)

Subjects
Male, POLYPS, Cancer Research, Pathology, Colorectal cancer, medicine.medical_treatment, viruses, JC virus, PROTEIN, medicine.disease_cause, Polymerase Chain Reaction, Adenomatous Polyps, Antigens, Viral, Tumor, POPULATION, Aged, 80 and over, RISK, education.field_of_study, COLON-CANCER, virus diseases, Immunosuppression, Middle Aged, PRIMARY SCLEROSING CHOLANGITIS, Prognosis, JC Virus, Oncology, ULCERATIVE-COLITIS, Adenocarcinoma, Female, Colorectal Neoplasms, Adenoma, Adult, medicine.medical_specialty, Adolescent, Population, HUMAN POLYOMAVIRUS, Article, Young Adult, medicine, Humans, education, Aged, Immunosuppression Therapy, Polyomavirus Infections, T-ANTIGEN, business.industry, Cancer, medicine.disease, Liver Transplantation, Transplantation, Tumor Virus Infections, RECIPIENTS, Case-Control Studies, DNA, Viral, Cancer research, Virus Activation, business
Abstract

Purpose: Liver transplant recepients (LTRs) have an increased risk of colorectal neoplasia. The mechanism responsible for this is unknown. JCV encodes for TAg and has been implicated in colorectal carcinogenesis. We hypothesized that the use of immunosuppression in LTRs facilitates activation of JCV and is responsible for the increased risk of neoplasia. Experimental Design: JCV TAg DNA and protein expression were determined in normal colonic epithelium (n = 15) and adenomatous polyps (n = 26) from LTRs and compared with tissue samples from control patients (normal colon, n = 21; adenomas, n = 40). Apoptosis and proliferation were determined by M30 and Ki-67 immunoreactivity, respectively. Results: JCV TAg DNA was found in 10 of 15 (67%) of normal colonic mucosa from LTRs compared with 5 of 21 (24%) of control normal mucosa (P = 0.025). JCV TAg DNA was detected in 16 of 26 (62%) of the adenomas from LTRs and in 20 of 40 (50%) of control adenomas. JCV TAg protein was expressed in 13 of 26 (50%) adenomas from LTRs versus 2 of 40 (5%) of adenomas from controls (P < 0.001). In adenomas from LTRs, the mean proliferative activity was higher compared with controls (60.3 ± 3.2% versus 42.7 ± 2.8%, P < 0.001), whereas mean apoptotic indices were lower in LTRs (0.29 ± 0.08% versus 0.39 ± 0.06%, P = 0.05). Conclusions: The presence of JCV in the colorectal mucosa and adenomas from LTRs, in concert with the use of immunosuppressive agents, suggests that JCV may undergo reactivation, and the subsequent TAg protein expression might explain the increased risk of colorectal neoplasia in LTRs.

Published
2008

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