10 results on '"Zhu, Chen"'
Search Results
2. Novel DNA methylation biomarkers in stool and blood for early detection of colorectal cancer and precancerous lesions
- Author
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Shen, Yuguang, Wang, Dongyang, Yuan, Tianli, Fang, Hongsheng, Zhu, Chen, Qin, Juan, Xu, Xiaojing, Zhang, Cheng, Liu, Jiahua, Zhang, Yuanruohan, Wen, Zhoujin, Tang, Jian, and Wang, Zheng
- Published
- 2023
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3. A Metabolomic Signature of Obesity and Risk of Colorectal Cancer: Two Nested Case–Control Studies.
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Yang, Mingjia, Zhu, Chen, Du, Lingbin, Huang, Jianv, Lu, Jiayi, Yang, Jing, Tong, Ye, Zhu, Meng, Song, Ci, Shen, Chong, Dai, Juncheng, Lu, Xiangfeng, Xu, Zekuan, Li, Ni, Ma, Hongxia, Hu, Zhibin, Gu, Dongfeng, Jin, Guangfu, Hang, Dong, and Shen, Hongbing
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COLORECTAL cancer ,METABOLOMICS ,DISEASE risk factors ,CASE-control method ,BODY mass index - Abstract
Obesity is a leading contributor to colorectal cancer (CRC) risk, but the metabolic mechanisms linking obesity to CRC are not fully understood. We leveraged untargeted metabolomics data from two 1:1 matched, nested case–control studies for CRC, including 223 pairs from the US Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial and 190 pairs from a prospective Chinese cohort. We explored serum metabolites related to body mass index (BMI), constructed a metabolomic signature of obesity, and examined the association between the signature and CRC risk. In total, 72 of 278 named metabolites were correlated with BMI after multiple testing corrections (p FDR < 0.05). The metabolomic signature was calculated by including 39 metabolites that were independently associated with BMI. There was a linear positive association between the signature and CRC risk in both cohorts (p for linear < 0.05). Per 1-SD increment of the signature was associated with 38% (95% CI: 9–75%) and 28% (95% CI: 2–62%) higher risks of CRC in the US and Chinese cohorts, respectively. In conclusion, we identified a metabolomic signature for obesity and demonstrated the association between the signature and CRC risk. The findings offer new insights into the underlying mechanisms of CRC, which is critical for improved CRC prevention. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
4. MicroRNA Response and Toxicity of Potential Pathways in Human Colon Cancer Cells Exposed to Titanium Dioxide Nanoparticles
- Author
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Zhu Chen, Wen Li, Jian Hui Wang, Jie Ba, Zavuga Zuberi, Sheng Yang, Ming Xi Jia, and Jing Deng
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inorganic chemicals ,0301 basic medicine ,Cancer Research ,bioinformatics analysis ,Colorectal cancer ,lcsh:RC254-282 ,Article ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,In vivo ,mental disorders ,microRNA ,medicine ,Cytotoxicity ,health care economics and organizations ,TiO2-NPs ,Chemistry ,technology, industry, and agriculture ,respiratory system ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,human colon cancer cell ,030104 developmental biology ,Oncology ,Cell culture ,Apoptosis ,030220 oncology & carcinogenesis ,Toxicity ,Cancer research ,cytotoxicity - Abstract
Titanium dioxide nanoparticles (TiO2-NPs) are widely used for biomedical and food applications, the toxicity of TiO2-NPs in vivo and in vitro has been elucidated, but the underlying cytotoxicity of TiO2-NPs against microRNA remains largely unknown. The purpose of this study was to analyze microRNA profiling induced by TiO2-NPs against NCM460 and HCT116 cell lines. Comparative analysis identified 34 and 24 microRNAs were significantly altered in the TiO2-NPs treated cells at concentrations of 3 and 30 &mu, g/mL, respectively. Functional classification demonstrated that a large proportion of genes involved in metabolism, human disease, and environmental information process were significantly upregulated by TiO2-NPs. Bioinformatics analysis suggested that microRNA 378 might be an early indicator of cellular response to exogenous stimuli with apoptotic signals. Furthermore, TiO2-NPs significantly altered the expression of microRNA 378b and 378g in HCT116 and NCM460 cell lines at different concentrations from 3 to 6 &mu, g/mL. These concentrations elicit high-sensitivity of stimuli response in colon cancer cells when exposed to the slight doses of TiO2-NPs. Our study indicated that microRNAs 378b and 378g may play an important role in TiO2-NPs-mediated colonic cytotoxicity, which may provide a valuable insight into the molecular mechanisms of potential risks in colitis and colon cancer.
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- 2020
5. Associations of body mass index with cancer incidence among populations, genders, and menopausal status: A systematic review and meta-analysis
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Jun Wang, Zhong-Zhu Chen, Dong-Lin Yang, and Ben-Fu Gou
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Oncology ,Cancer Research ,medicine.medical_specialty ,Epidemiology ,Colorectal cancer ,Population ,Overweight ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Internal medicine ,medicine ,030212 general & internal medicine ,Risk factor ,education ,education.field_of_study ,business.industry ,Incidence (epidemiology) ,Cancer ,medicine.disease ,030220 oncology & carcinogenesis ,medicine.symptom ,business ,Body mass index ,Demography - Abstract
In order to further reveal the differences of association between body mass index (BMI) and cancer incidence across populations, genders, and menopausal status, we performed comprehensive meta-analysis with eligible citations. The risk ratio (RR) of incidence at 10 different cancer sites (per 5kg/m(2) increase in BMI) were quantified separately by employing generalized least-squares to estimate trends, and combined by meta-analyses. We observed significantly stronger association between increased BMI and breast cancer incidence in the Asia-Pacific group (RR 1.18:1.11-1.26) than in European-Australian (1.05:1.00-1.09) and North-American group (1.06:1.03-1.08) (meta-regression p
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- 2016
6. Correction: Colorectal Cancer Linkage on Chromosomes 4q21, 8q13, 12q24, and 15q22
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D. Timothy Bishop, Brenda Diergaarde, Julie M. Cunningham, Daniel D. Buchanan, Allyson Templeton, Polly A. Newcomb, Finlay A. Macrae, Robert W. Haile, Duncan Thomas, Susan Parry, Daniel J. Serie, Zhu Chen, Fredrick R. Schumacher, John D. Potter, Melissa S. DeRycke, H. Banfield Younghusband, Steven Gallinger, Noralane M. Lindor, John L. Hopper, Ellen L. Goode, Ingrid Winship, Mine S. Cicek, Brooke L. Fridley, Theodore G. Krontiris, William R. Bamlet, Loic Le Marchand, Joanne P. Young, Graham Casey, Stephen N. Thibodeau, Mark A. Jenkins, Graeme P. Young, Roger C. Green, and Jane Green
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Linkage (software) ,Multidisciplinary ,business.industry ,Colorectal cancer ,lcsh:R ,Correction ,lcsh:Medicine ,Computational biology ,Bioinformatics ,medicine.disease ,Medicine ,lcsh:Q ,lcsh:Science ,business - Published
- 2012
7. Structural shifts of gut microbiota as surrogate endpoints for monitoring host health changes induced by carcinogen exposure.
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Hua Wei, Li Dong, Tingting Wang, Menghui Zhang, Weiying Hua, Chenhong Zhang, Xiaoyan Pang, Minjun Chen, Mingming Su, Yunping Qiu, Mingmei Zhou, Shengli Yang, Zhu Chen, Rantalainen, Mattias, Nicholson, Jeremy K., Wei Jia, Dazheng Wu, and Liping Zhao
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DENATURING gradient gel electrophoresis ,MICROBIOLOGY ,PROKARYOTES ,CARCINOGENESIS - Abstract
This study monitored structural shifts of gut microbiota of rats developing precancerous mucosal lesions induced by carcinogen 1,2-dimethyl hydrazine (DMH) treatment using PCR-denaturing gradient gel electrophoresis (DGGE) and 454 pyrosequencing on the 16S rRNA gene V3 region. Partial least square discriminant analysis of DGGE fingerprints showed that the gut microbiota structure of treated animals was similar to that of the controls 1 and 3 weeks after DMH treatments, but significantly different 7 weeks after DMH treatments, when a large number of aberrant crypt foci (ACF) developed in their colons. Martens' uncertainty test, followed byanova test ( P<0.05) identified Ruminococcus-like and Allobaculum-like bacteria as key variables for discrimination of DMH-treated rats from controls. Real-time PCR confirmed the significant increase of the Ruminococcus obeum and the Allobaculum-like bacteria in DMH-treated rats. UniFrac analysis based on V3 pyrosequencing further validated that the gut microbiota structures of treated and control animals were similar at an early stage, but segregated after ACF formation. Thirteen operational taxonomic units including Ruminococcus-like and Allobaculum-like bacteria were identified as key variables for the discrimination of DMH-treated rats from controls. Dynamic analysis of gut microbiota may become a noninvasive strategy for monitoring host health changes induced by carcinogen exposure. [ABSTRACT FROM AUTHOR]
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- 2010
- Full Text
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8. Oxaliplatin-induced hepatic sinusoidal obstruction syndrome.
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Zhu, Chen, Ren, Xiuhua, Liu, Dong, and Zhang, Chengliang
- Subjects
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HEPATIC veno-occlusive disease , *COLORECTAL cancer , *PORTAL hypertension , *ANTINEOPLASTIC agents , *VENOUS pressure , *KOUNIS syndrome , *METASTASIS - Abstract
Oxaliplatin (OXA) is a third-generation platinum anticancer drug that is mainly used for the treatment of metastatic colorectal cancer (CRC). Of note, hepatic sinusoidal obstruction syndrome (HSOS) induced by OXA has become a key concern for patients with CRC receiving chemotherapy with OXA in recent years. Splenomegaly, thrombocytopenia, abnormal liver function, and portal hypertension are some of the main clinical characteristics seen in patients with OXA-induced HSOS. Previous studies have suggested that oxidative stress, inflammatory damage, liver fibrosis, and platelet aggregation and adhesion may be involved in the pathogenesis of OXA-induced HSOS. Currently, there are no specific drugs for prevention and treatment of OXA-induced HSOS. In this review, we summarized the epidemiology, pathological characteristics, clinical predictive indicators, related mechanisms, possible prevention and treatment of OXA-related HSOS. [ABSTRACT FROM AUTHOR]
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- 2021
- Full Text
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9. Targeted metabolomics analysis of nucleosides and the identification of biomarkers for colorectal adenomas and colorectal cancer
- Author
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Weifang Zheng, Mingwei Wang, Xiaoyin Chai, Fuzhen Pan, Meihui Xu, Yingchen Wang, Liuhao Lan, Feiran Hu, Zhe Zhang, and Zhu Chen
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colorectal cancer ,colorectal adenomas ,LC-MS/MS ,nucleosides ,serum ,biomarker ,Biology (General) ,QH301-705.5 - Abstract
The morbidity and mortality of colorectal cancer (CRC) have been increasing in recent years, and early detection of CRC can improve the survival rate of patients. RNA methylation plays crucial roles in many biological processes and has been implicated in the initiation of various diseases, including cancer. Serum contains a variety of biomolecules and is an important clinical sample for biomarker discovery. In this study, we developed a targeted metabolomics method for the quantitative analysis of nucleosides in human serum samples by using liquid chromatography with tandem mass spectrometry (LC-MS/MS). We successfully quantified the concentrations of nucleosides in serum samples from 51 healthy controls, 37 patients with colorectal adenomas, and 55 patients with CRC. The results showed that the concentrations of N6-methyladenosine (m6A), N1-methyladenosine (m1A), and 3-methyluridine (m3U) were increased in patients with CRC, whereas the concentrations of N2-methylguanosine (m2G), 2′-O-methyluridine (Um), and 2′-O-methylguanosine (Gm) were decreased in patients with CRC, compared with the healthy controls and patients with colorectal adenomas. Moreover, the levels of 2′-O-methyluridine and 2′-O-methylguanosine were lower in patients with colorectal adenomas than those in healthy controls. Interestingly, the levels of Um and Gm gradually decreased in the following order: healthy controls to colorectal adenoma patients to CRC patients. These results revealed that the aberrations of these nucleosides were tightly correlated to colorectal adenomas and CRC. In addition, the present work will stimulate future investigations about the regulatory roles of these nucleosides in the initiation and development of CRC.
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- 2023
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10. Development and evaluation of a risk prediction tool for risk-adapted screening of colorectal cancer in China.
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Hang, Dong, Sun, Dianjianyi, Du, Lingbin, Huang, Jianv, Li, Jiacong, Zhu, Chen, Wang, Le, He, Jingjing, Zhu, Xia, Zhu, Meng, Song, Ci, Dai, Juncheng, Yu, Canqing, Xu, Zekuan, Li, Ni, Ma, Hongxia, Jin, Guangfu, Yang, Ling, Chen, Yiping, and Du, Huaidong
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COLORECTAL cancer , *DISEASE risk factors , *EARLY detection of cancer , *RISK assessment , *MEDICAL screening - Abstract
Risk prediction tools for colorectal cancer (CRC) have potential to improve the efficiency of population-based screening by facilitating risk-adapted strategies. However, such an applicable tool has yet to be established in the Chinese population. In this study, a risk score was created using data from the China Kadoorie Biobank (CKB), a nationwide cohort study of 409,854 eligible participants. Diagnostic performance of the risk score was evaluated in an independent CRC screening programme, which included 91,575 participants who accepted colonoscopy at designed hospitals in Zhejiang Province, China. Over a median follow-up of 11.1 years, 3136 CRC cases were documented in the CKB. A risk score was created based on nine questionnaire-derived variables, showing moderate discrimination for 10-year CRC risk (C-statistic = 0.68, 95 % CI: 0.67–0.69). In the CRC screening programme, the detection rates of CRC were 0.25 %, 0.82 %, and 1.93 % in low-risk (score <6), intermediate-risk (score: 6–19), and high-risk (score >19) groups, respectively. The newly developed score exhibited a C-statistic of 0.65 (95 % CI: 0.63–0.66), surpassing the widely adopted tools such as the Asia-Pacific Colorectal Screening (APCS), modified APCS, and Korean Colorectal Screening scores (all C-statistics = 0.60). In conclusion, we developed a novel risk prediction tool that is useful to identify individuals at high risk of CRC. A user-friendly online calculator was also constructed to encourage broader adoption of the tool. • We developed a new risk score that effectively stratified individuals based on their CRC risk. • The novel risk score outperformed commonly used models in identifying individuals at risk for CRC. • We made the tool easily accessible online, allowing the general population to actively engage in CRC prevention. [ABSTRACT FROM AUTHOR]
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- 2024
- Full Text
- View/download PDF
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