Search

Your search keyword '"predicting response to therapy"' showing total 2 results
Start Over Descriptor "predicting response to therapy" Topic colorectal cancer
2 results on '"predicting response to therapy"'

1. Rola profilowania genowego z zastosowaniem macierzy DNA w diagnostyce, określaniu rokowania i odpowiedzi na leczenie w raku jelita grubego.

Author

Kwiatkowski, Przemysław, Wierzbicki, Piotr, Kmieć, Andrzej, and Godlewski, Janusz

Subjects
*GENE expression profiling, *DNA microarrays, *COLON cancer diagnosis, *COLON cancer treatment, *GASTROINTESTINAL cancer, *CELL proliferation, *CELL differentiation
Abstract

Colorectal cancer is the most common cancer of the gastrointestinal tract. It is considered as a biological model of a certain type of cancerogenesis process in which progression from an early to late stage adenoma and cancer is accompanied by distinct genetic alterations. Clinical and pathological parameters commonly used in clinical practice are often insufficient to determine groups of patients suitable for personalized treatment. Moreover, reliable molecular markers with high prognostic value have not yet been determined. Molecular studies using DNAbased microarrays have identified numerous genes involved in cell proliferation and differentiation during the process of cancerogenesis. Assessment of the genetic profile of colorectal cancer using the microarray technique might be a useful tool in determining the groups of patients with different clinical outcomes who would benefit from additional personalized treatment. The main objective of this study was to present the current state of knowledge on the practical application of gene profiling techniques using microarrays for determining diagnosis, prognosis and response to treatment in colorectal cancer. [ABSTRACT FROM AUTHOR]

Published
2012
Full Text
View/download PDF

2. DNA microarray-based gene expression profiling in diagnosis, assessing prognosis and predicting response to therapy in colorectal cancer

Author

Andrzej Kmieć, Przemyslaw Kwiatkowski, Janusz Godlewski, and Piotr M. Wierzbicki

Subjects
Adenoma, Genetic Markers, Microbiology (medical), Microarray, Colorectal cancer, lcsh:Medicine, colorectal cancer, Medical Oncology, Bioinformatics, assessing prognosis, Transcriptome, profilowanie genowe, Humans, Medicine, Pathological, Gene, Oligonucleotide Array Sequence Analysis, business.industry, Gene Expression Profiling, lcsh:R, DNA microarray, mikromacierze, DNA, Prognosis, medicine.disease, Gene expression profiling, Treatment Outcome, Infectious Diseases, gene profiling, Mutation, Disease Progression, rak jelita grubego, Colorectal Neoplasms, business, predicting response to therapy
Abstract

Colorectal cancer is the most common cancer of the gastrointestinal tract. It is considered as a biological model of a certain type of cancerogenesis process in which progression from an early to late stage adenoma and cancer is accompanied by distinct genetic alterations. Clinical and pathological parameters commonly used in clinical practice are often insufficient to determine groups of patients suitable for personalized treatment. Moreover, reliable molecular markers with high prognostic value have not yet been determined. Molecular studies using DNA-based microarrays have identified numerous genes involved in cell proliferation and differentiation during the process of cancerogenesis. Assessment of the genetic profile of colorectal cancer using the microarray technique might be a useful tool in determining the groups of patients with different clinical outcomes who would benefit from additional personalized treatment. The main objective of this study was to present the current state of knowledge on the practical application of gene profiling techniques using microarrays for determining diagnosis, prognosis and response to treatment in colorectal cancer.

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results