16 results on '"Menko, F H"'
Search Results
2. Genomic deletions of MSH2 and MLH1 in colorectal cancer families detected by a novel mutation detection approach.
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Gille JJ, Hogervorst FB, Pals G, Wijnen JT, van Schooten RJ, Dommering CJ, Meijer GA, Craanen ME, Nederlof PM, de Jong D, McElgunn CJ, Schouten JP, and Menko FH
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- Adaptor Proteins, Signal Transducing, Base Pair Mismatch genetics, Carrier Proteins, Cohort Studies, DNA Repair genetics, Family, Female, Germ-Line Mutation, Humans, Male, MutL Protein Homolog 1, MutS Homolog 2 Protein, Nuclear Proteins, Pedigree, Polymerase Chain Reaction, Colorectal Neoplasms genetics, Colorectal Neoplasms, Hereditary Nonpolyposis genetics, DNA-Binding Proteins, Gene Deletion, Neoplasm Proteins genetics, Proto-Oncogene Proteins genetics
- Abstract
Hereditary non-polyposis colorectal cancer is an autosomal dominant condition due to germline mutations in DNA-mismatch-repair genes, in particular MLH1, MSH2 and MSH6. Here we describe the application of a novel technique for the detection of genomic deletions in MLH1 and MSH2. This method, called multiplex ligation-dependent probe amplification, is a quantitative multiplex PCR approach to determine the relative copy number of each MLH1 and MSH2 exon. Mutation screening of genes was performed in 126 colorectal cancer families selected on the basis of clinical criteria and in addition, for a subset of families, the presence of microsatellite instability (MSI-high) in tumours. Thirty-eight germline mutations were detected in 37 (29.4%) of these kindreds, 31 of which have a predicted pathogenic effect. Among families with MSI-high tumours 65.7% harboured germline gene defects. Genomic deletions accounted for 54.8% of the pathogenic mutations. A complete deletion of the MLH1 gene was detected in two families. The multiplex ligation-dependent probe amplification approach is a rapid method for the detection of genomic deletions in MLH1 and MSH2. In addition, it reveals alterations that might escape detection using conventional diagnostic techniques. Multiplex ligation-dependent probe amplification might be considered as an early step in the molecular diagnosis of hereditary non-polyposis colorectal cancer., (Copyright 2002 Cancer Research UK)
- Published
- 2002
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3. MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers: a study of hereditary nonpolyposis colorectal cancer families.
- Author
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Vasen HF, Stormorken A, Menko FH, Nagengast FM, Kleibeuker JH, Griffioen G, Taal BG, Moller P, and Wijnen JT
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- Adaptor Proteins, Signal Transducing, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Base Pair Mismatch genetics, Carrier Proteins, Child, Child, Preschool, Colorectal Neoplasms, Hereditary Nonpolyposis epidemiology, DNA Repair genetics, Female, Heterozygote, Humans, Male, Middle Aged, MutL Protein Homolog 1, MutS Homolog 2 Protein, Netherlands epidemiology, Nuclear Proteins, Registries, Risk Factors, Sex Factors, Colorectal Neoplasms, Hereditary Nonpolyposis genetics, DNA-Binding Proteins, Mutation, Neoplasm Proteins genetics, Proto-Oncogene Proteins genetics
- Abstract
Purpose: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disease characterized by the clustering of colorectal cancer, endometrial cancer, and various other cancers. The disease is caused by mutations in DNA-mismatch-repair (MMR) genes, most frequently in MLH1, MSH2, and MSH6. The aims of the present study were to compare the risk of developing colorectal, endometrial, and other cancers between families with the various MMR-gene mutations., Patients and Methods: Clinical and pathologic data were collected from 138 families with HNPCC. Mutation analyses were performed for all families. Survival analysis was used to calculate the cumulative risk of developing cancer in the various subsets of relatives., Results: Mutations were identified in 79 families: 34 in MLH1, 40 in MSH2, and five in MSH6. The lifetime risk of developing cancer at any site was significantly higher for MSH2 mutation carriers than for MLH1 mutation carriers (P < .01). The risk of developing colorectal or endometrial cancer was higher in MSH2 mutation carriers than in MLH1 mutation carriers, but the difference was not significant (P = .13 and P = .057, respectively). MSH2 mutation carriers were found to have a significantly higher risk of developing cancer of the urinary tract (P < .05). The risk of developing cancer of the ovaries, stomach, and brain was also higher in the MSH2 mutation carriers than in the MLH1 mutation carriers, but the difference was not statistically significant., Conclusion: Pending large prospective studies, the extension of the current surveillance program in MSH2 mutation carriers with the inclusion of the urinary tract should be considered.
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- 2001
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4. [Genetics of colorectal cancer. I. Non-polyposis and polyposis forms of hereditary colorectal cancer].
- Author
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Menko FH, Griffioen G, Wijnen JT, Tops CM, Fodde R, and Vasen HF
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- Adenomatous Polyposis Coli epidemiology, Adenomatous Polyps genetics, Adenomatous Polyps surgery, Adolescent, Adult, Aged, Aged, 80 and over, Brain Neoplasms genetics, Child, Child, Preschool, Colorectal Neoplasms, Hereditary Nonpolyposis epidemiology, Female, Genes, APC genetics, Genetic Carrier Screening, Germ-Line Mutation genetics, Hamartoma Syndrome, Multiple epidemiology, Hamartoma Syndrome, Multiple genetics, Humans, Male, Middle Aged, Netherlands epidemiology, Peutz-Jeghers Syndrome epidemiology, Adenomatous Polyposis Coli genetics, Colorectal Neoplasms, Hereditary Nonpolyposis genetics, Neoplasms, Multiple Primary genetics, Peutz-Jeghers Syndrome genetics
- Abstract
About 5% of colorectal cancer cases are due to an autosomal dominant genetic predisposition with high penetrance. In this condition, the patient is carrier of a pathogenic gene mutation present in all body cells which can be transmitted to descendants, a so-called germ line mutation. The mutation is usually present in a tumour suppressor gene. Three subgroups of hereditary colorectal cancer can be distinguished on the basis of the clinical characteristics: (a) syndromes without polyposis (mostly hereditary non-polyposis colorectal carcinoma; HNPCC), (b) syndromes with adenomatous polyposis (mostly familial adenomatous polyposis; FAP) and (c) syndromes with hamartomatous polyposis. Recently, the main gene defects which underlie these syndromes were identified. Consequently, it is possible in approximately half the families with HNPCC or FAP in patients with colorectal cancer to demonstrate the causative gene defect and subsequently, by blood testing of healthy relatives to determine who is and is not a carrier of this hereditary condition. Thus, preventive measures can be directed toward family members with a demonstrable high risk of large bowel cancer.
- Published
- 1999
5. A cost-effectiveness analysis of colorectal screening of hereditary nonpolyposis colorectal carcinoma gene carriers.
- Author
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Vasen HF, van Ballegooijen M, Buskens E, Kleibeuker JK, Taal BG, Griffioen G, Nagengast FM, Menko FH, and Meera Khan P
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- Adult, Aged, Colonoscopy economics, Colorectal Neoplasms, Hereditary Nonpolyposis diagnosis, Colorectal Neoplasms, Hereditary Nonpolyposis economics, Cost-Benefit Analysis, Heterozygote, Humans, Male, Middle Aged, Colorectal Neoplasms, Hereditary Nonpolyposis genetics, Genetic Testing economics
- Abstract
Background: It has been estimated that the prevalence of carriers of a mutated mismatch repair (MMR) gene among the general population in Western countries is between 5 and 50 per 10,000. These carriers have a risk of >85% of developing colorectal carcinoma (CRC) and therefore need careful follow-up. The objective of this study was to analyze the cost-effectiveness of CRC surveillance of carriers of a mutated MMR gene., Methods: The authors constructed a model to estimate the potential health effects (life expectancy) and healthcare costs of two strategies: 1) surveillance, with colonoscopy every 2-3 years, and 2) no CRC surveillance. Estimates of the lifetime risk of developing CRC and the stage distribution of CRC for symptomatic patients were derived from the Dutch hereditary nonpolyposis colorectal carcinoma (HNPCC) registry. The CRC stage specific relative survival rates and the effectiveness of surveillance in preventing or detecting cancer early were based on Finnish studies. The costs of surveillance and treatment were derived from recent American studies., Results: The results showed that 1) surveillance of gene carriers led to an increase in life expectancy of 7 years, and 2) the costs of surveillance under a wide range of assumptions are less than the costs of no CRC surveillance., Conclusions: CRC surveillance of HNPCC gene carriers appears to be effective and considerably less costly than no CRC surveillance and therefore deserves to be supported by governmental agencies and health insurance organizations.
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- 1998
6. Familial and hereditary non-polyposis colorectal cancer: issues relevant for surgical practice.
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Menko FH, Wijnen JT, Vasen HF, Sijmons RH, and Khan PM
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- Adenomatous Polyps diagnosis, Colorectal Neoplasms, Hereditary Nonpolyposis diagnosis, DNA, Neoplasm analysis, Female, Humans, Male, Pedigree, Adenomatous Polyps surgery, Colorectal Neoplasms, Hereditary Nonpolyposis surgery
- Abstract
About 15% of patients with colorectal cancer report a family history of this disease. An estimated 1%-5% of patients have hereditary non-polyposis colorectal cancer (HNPCC). Recently, DNA mismatch repair genes associated with this syndrome were identified. For about 50% of families in which HNPCC occurs, DNA-based diagnosis and presymptomatic DNA testing are now feasible. Diagnosis of a hereditary tumour syndrome is relevant for both the patient with cancer and his or her close relatives. The complexities of family studies warrant the forming of a multidisciplinary team which may choose to work within a specialized cancer family clinic.
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- 1998
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7. Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis.
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Vasen HF, Wijnen JT, Menko FH, Kleibeuker JH, Taal BG, Griffioen G, Nagengast FM, Meijers-Heijboer EH, Bertario L, Varesco L, Bisgaard ML, Mohr J, Fodde R, and Khan PM
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- Adolescent, Adult, Aged, DNA Mutational Analysis, DNA Repair genetics, Female, Genes, Heterozygote, Humans, Intestinal Neoplasms genetics, Intestine, Small, Male, Middle Aged, Ovarian Neoplasms genetics, Risk, Stomach Neoplasms genetics, Urologic Neoplasms genetics, Colorectal Neoplasms, Hereditary Nonpolyposis genetics, Family Health, Mutation
- Abstract
Background & Aims: Hereditary nonpolyposis colorectal cancer is characterized by early-onset colorectal cancer and the occurrence of various other cancers. The recent isolation of four mismatch repair genes responsible for hereditary nonpolyposis colorectal cancer allows for the identification of carriers within affected families. The purpose of this study was to assess the age-specific cancer risk in a large series of gene carriers., Methods: Thirty-four families were studied by mutation analysis. In 19 of these families, pathogenic mutations were found at hMSH2 or hMLH1. Of 382 relatives, 124 had a mutation in hMLH1 and 86 in hMSH2., Results: The lifetime risk of colorectal cancer was the same in both groups of gene carriers (80%). The risk of endometrial cancer was greater in hMSH2 gene carriers compared with hMLH1 gene carriers (61% vs. 42%), but the difference was not statistically significant. A very high relative risk of cancer of the small bowel (relative risk of >100) was observed in carriers of either gene. Only the carriers of hMSH2 mutations had a significantly increased relative risk of cancer of the urinary tract (kidney and ureter) (relative risk of 75.3), stomach (relative risk of 19.3), and ovaries (relative risk of 8.0)., Conclusions: This study provides estimates of cancer risk that may contribute to the appropriate management of gene carriers within families with hereditary nonpolyposis colorectal cancer.
- Published
- 1996
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8. The risk of brain tumours in hereditary non-polyposis colorectal cancer (HNPCC).
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Vasen HF, Sanders EA, Taal BG, Nagengast FM, Griffioen G, Menko FH, Kleibeuker JH, Houwing-Duistermaat JJ, and Meera Khan P
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- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Pedigree, Risk, Brain Neoplasms etiology, Colorectal Neoplasms, Hereditary Nonpolyposis complications
- Abstract
Hereditary non-polyposis colorectal cancer (HNPCC) is known to be associated with several extracolonic cancers, e.g., cancers of the endometrium, stomach, urinary tract, small bowel and ovary. An association between HNPCC and brain tumours has also been reported, although previous risk analysis did not reveal an excess of this type of tumour. To determine whether HNPCC predisposes patients to brain tumours, we used risk analysis to compare families with HNPCC to those in the general population. Of the 1,321 subjects from 50 HNPCC families (with 60,237 person-years of follow-up) in the Dutch HNPCC Registry which satisfy the Amsterdam Criteria, 312 had colorectal cancer. The registry revealed 14 brain tumours in the HNPCC-patients and their first-degree relatives: 5 astrocytomas, 3 oligodendrogliomas, 1 ependymoma and 5 tumours for which a pathological report was not available. The relative risk of brain tumour in patients with HNPCC and their first-degree relatives was 6 times greater than in the general population (95% confidence interval, 3.5 to 10.1). After exclusion of the cases based only on family history, the relative risk was 4.3 (95% confidence interval, 2.3 to 8.0). Although the relative risk of brain tumour was increased, the lifetime risk was low (3.35%). Because it is not certain whether an improvement of the overall prognosis can be achieved by early diagnosis and intervention, and in view of the low lifetime risk, we do not recommend screening for brain tumours in HNPCC families.
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- 1996
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9. Genetic counseling in hereditary nonpolyposis colorectal cancer.
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Menko FH, Wijnen JT, Khan PM, Vasen HF, and Oosterwijk MH
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- Colorectal Neoplasms, Hereditary Nonpolyposis genetics, Colorectal Neoplasms, Hereditary Nonpolyposis psychology, Female, Genetic Testing psychology, Humans, Male, Pedigree, Colorectal Neoplasms, Hereditary Nonpolyposis prevention & control, Genetic Counseling
- Abstract
Recent identification of gene mutations responsible for hereditary nonpolyposis colorectal cancer (HNPCC) has made possible the presymptomatic diagnosis of at-risk family members. If DNA testing shows that a family member is a gene carrier, that individual's lifetime cancer risk is approximately 90%. If the test is negative, the family member's cancer risk drops to that of the general population. Presymptomatic DNA-based diagnosis consists of pretest counseling, the actual DNA test, and posttest counseling. Pretest counseling focuses on the benefits, limitations, and possible adverse effects of testing, and the advantages and drawbacks of screening methods. Posttest counseling sessions explore the test result, and family members' reactions to it. A multidisciplinary team approach is necessary for the management of HNPCC families.
- Published
- 1996
10. Hereditary nonpolyposis colorectal cancer: results of long-term surveillance in 50 families.
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Vasen HF, Taal BG, Nagengast FM, Griffioen G, Menko FH, Kleibeuker JH, Offerhaus GJ, and Meera Khan P
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- Adenoma genetics, Adenoma pathology, Adolescent, Adult, Aged, Aged, 80 and over, Colonoscopy, Colorectal Neoplasms, Hereditary Nonpolyposis mortality, Female, Follow-Up Studies, Humans, Long-Term Care, Male, Middle Aged, Sigmoidoscopy, Survival Rate, Adenoma diagnosis, Colorectal Neoplasms, Hereditary Nonpolyposis diagnosis, Colorectal Neoplasms, Hereditary Nonpolyposis genetics
- Abstract
A surveillance programme comprising either colonoscopy of sigmoidoscopy plus barium enema every 2-3 years was instituted in 50 hereditary nonpolyposis colorectal cancer (HNPCC) families. The families included 238 patients with colorectal cancer (CRC) (mean age at diagnosis: 43.7 years; range: 16-86 years). These patients had 597 first-degree relatives of whom 493 could be traced and 388 (79%) accepted the invitation for screening. The control group were relatives (index patients) with symptomatic CRC. The average follow-up duration was 5 years (1-20 years). Screening led to the detection of adenomas in 33 patients and CRC in 11 patients. Pathological examination revealed 1 Dukes' A, 7 Dukes' B and 3 Dukes' C cancers. In contrast, among the control group 47% had advanced CRC (Dukes' C or distant metastases). The 5-year survival of the screen-detected cases was 87% versus 63% in the control group. Of the 11 CRC cases in the screening group, 4 were detected within 1-4 years after a negative colonic examination. A large proportion of the polyps found in the screening and control groups showed a villous growth pattern and/or a high degree of dysplasia. We conclude that periodic examination of HNPCC families allows the detection of cancer at an earlier stage than in patients not under surveillance. Because of the possibly more aggressive nature of polyps associated with HNPCC, we recommend a screening interval of 1-2 years.
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- 1995
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11. Seven new mutations in hMSH2, an HNPCC gene, identified by denaturing gradient-gel electrophoresis.
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Wijnen J, Vasen H, Khan PM, Menko FH, van der Klift H, van Leeuwen C, van den Broek M, van Leeuwen-Cornelisse I, Nagengast F, and Meijers-Heijboer A
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- Base Sequence, Colorectal Neoplasms, Hereditary Nonpolyposis epidemiology, Denmark epidemiology, Electrophoresis, Exons genetics, Humans, Italy epidemiology, Molecular Sequence Data, MutS Homolog 2 Protein, Netherlands epidemiology, Nucleic Acid Denaturation, Pilot Projects, Polymerase Chain Reaction, Polymorphism, Genetic, Sequence Analysis, DNA, Colorectal Neoplasms, Hereditary Nonpolyposis genetics, DNA-Binding Proteins, Mutation, Proto-Oncogene Proteins genetics
- Abstract
Hereditary nonpolyposis colorectal cancer (HNPCC) is a relatively common autosomal dominant cancer-susceptibility condition. The recent isolation of the DNA mismatch repair genes (hMSH2, hMLH1, hPMS1, and hPMS2) responsible for HNPCC has allowed the search for germ-line mutations in affected individuals. In this study we used denaturing gradient-gel electrophoresis to screen for mutations in the hMSH2 gene. Analysis of all the 16 exons of hMSH2, in 34 unrelated HNPCC kindreds, has revealed seven novel pathogenic germ-line mutations resulting in stop codons either directly or through frameshifts. Additionally, nucleotide substitutions giving rise to one missense, two silent, and one useful polymorphism have been identified. The proportion of families in which hMSH2 mutations were found is 21%. Although the spectrum of mutations spread at the hMSH2 gene among HNPCC patients appears extremely heterogeneous, we were not able to establish any correlation between the site of the individual mutations and the corresponding tumor spectrum. Our results indicate that, given the genomic size and organization of the hMSH2 gene and the heterogeneity of its mutation spectrum, a rapid and efficient mutation detection procedure is necessary for routine molecular diagnosis and presymptomatic detection of the disease in a clinical setup.
- Published
- 1995
12. Clinical heterogeneity of familial colorectal cancer and its influence on screening protocols.
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Vasen HF, Taal BG, Griffioen G, Nagengast FM, Cats A, Menko FH, Oskam W, Kleibeuker JH, Offerhaus GJ, and Khan PM
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- Adolescent, Adult, Age of Onset, Aged, Brain Neoplasms epidemiology, Breast Neoplasms epidemiology, Colorectal Neoplasms, Hereditary Nonpolyposis genetics, Endometrial Neoplasms epidemiology, Female, Humans, Lung Neoplasms epidemiology, Male, Middle Aged, Ovarian Neoplasms epidemiology, Pedigree, Stomach Neoplasms epidemiology, Urologic Neoplasms epidemiology, Colorectal Neoplasms, Hereditary Nonpolyposis epidemiology
- Abstract
The age at onset of non-polyposis colorectal cancer (CRC) was investigated in 49 families with at least three relatives affected in two successive generations. Forty one of these families satisfy the accepted minimum criteria for hereditary non-polyposis CRC. The remaining eight families were distinguished by a late age of disease onset and, hence, could not be included in the group. The condition in these latter families has been designated provisionally, as late onset familial CRC. The hereditary non-polyposis CRC families include 194 patients, 110 men and 84 women (mean age at diagnosis: 44 years; range: 16-74 years). Ninety two per cent of the patients were diagnosed by age 60. Colorectal cancer was diagnosed at progressively earlier ages in successive generations (p < 0.0005). The late onset CRC families comprised 30 patients, 20 men and 10 women (mean age at diagnosis: 62 years; range: 51-77 years). Fifty eight per cent of the CRCs in the patients belonging to the hereditary non-polyposis CRC families were located in the right colon compared with 13% in the late onset familial CRC group (p < 0.001). Multiple CRCs were found in 23% of the cases in the former but in only 3% in the latter families (p < 0.05). Adenomas associated with CRC were reported in 14.5% of the cases in the hereditary non-polyposis CRC families and in 30% of the cases in the late onset familial CRC group (p = NS). Extracolonic cancers, frequently encountered in hereditary non-polyposis CRC, were not found in the late onset CRC families. These findings indicate that there is a distinct clinical entity of non-polyposis CRC in which colorectal cancer develops at a more advanced age than in hereditary non-polyposis CRC. Future molecular genetic studies should confirm this hypothesis. In the meantime, recognition of these late onset familial CRC families, which will rest on clinical observations, is important because of the implications for the screening protocol.
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- 1994
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13. Variable age of onset in hereditary nonpolyposis colorectal cancer: clinical implications.
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Menko FH, te Meerman GJ, and Sampson JR
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- Adult, Age Factors, Aged, Humans, Middle Aged, Pedigree, Colorectal Neoplasms, Hereditary Nonpolyposis genetics
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- 1993
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14. [Hereditary aspects of colon and rectum carcinoma; risk assessment for relatives of patients and advice for screening].
- Author
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Menko FH
- Subjects
- Barium Sulfate, Chromosomes, Human, Pair 18, Colonoscopy, Colorectal Neoplasms, Hereditary Nonpolyposis genetics, Colorectal Neoplasms, Hereditary Nonpolyposis prevention & control, DNA Probes, Enema, Humans, Occult Blood, Risk, Colorectal Neoplasms, Hereditary Nonpolyposis classification
- Published
- 1991
15. The tumour spectrum in hereditary non-polyposis colorectal cancer: a study of 24 kindreds in the Netherlands.
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Vasen HF, Offerhaus GJ, den Hartog Jager FC, Menko FH, Nagengast FM, Griffioen G, van Hogezand RB, and Heintz AP
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- Adult, Age Factors, Aged, Aged, 80 and over, Colorectal Neoplasms, Hereditary Nonpolyposis genetics, Female, Humans, Incidence, Male, Middle Aged, Neoplasms, Multiple Primary epidemiology, Neoplasms, Multiple Primary genetics, Netherlands epidemiology, Pedigree, Sex Factors, Syndrome, Acetyltransferases analysis, Colorectal Neoplasms, Hereditary Nonpolyposis epidemiology
- Abstract
The hereditary colonic cancer syndrome without polyposis, hereditary non-polyposis colorectal cancer (HNPCC), is usually divided into 2 main categories: hereditary site-specific colorectal cancer (Lynch syndrome I) and colorectal cancer in association with other forms of cancer (Lynch syndrome II). One problem associated with Lynch II is the uncertainty as to which types of cancer form part of the hereditary tumour spectrum. The present study was performed to obtain more information about the tumour spectrum of HNPCC. In the 24 HNPCC families studied, 104 patients had colorectal cancer (mean age at diagnosis: 46 years) and in 4 of the families this was the only type of cancer to occur. Sixty-five extra-colonic tumours were diagnosed in 20 families. Endometrial carcinoma was found in 16 patients belonging to 12 families. Cancer of the stomach occurred in 10 patients representing 5 families, and mainly in the older generations. Urinary-tract tumours were found in 8 patients from 4 families. Second primary tumours were diagnosed in 13 of the 16 patients with endometrial cancer, in 4 of the 10 patients with stomach cancer and in 7 of the 8 patients with a urinary-tract tumour. Many other types of carcinoma were found as well, but less frequently. In our families, the trait appears to be transmitted by patients with cancer of the stomach, endometrium or urinary tract, because some of their children have developed colorectal cancer. The findings suggest that, in these 24 HNPCC families, carcinomas of the endometrium, stomach and urinary tract belong to the hereditary tumour spectrum. Definite assignment of tumours to this spectrum will become possible only after a sensitive and specific biomarker becomes available. The screening programme should depend on which and how many extra-colonic tumours occur in a family.
- Published
- 1990
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16. Screening for hereditary non-polyposis colorectal cancer: a study of 22 kindreds in The Netherlands.
- Author
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Vasen HF, den Hartog Jager FC, Menko FH, and Nagengast FM
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- Adenoma genetics, Adult, Aged, Aged, 80 and over, Carcinoma genetics, Carcinoma, Transitional Cell epidemiology, Colorectal Neoplasms, Hereditary Nonpolyposis pathology, Female, Humans, Male, Middle Aged, Neoplasm Staging, Neoplasms, Multiple Primary epidemiology, Netherlands, Urologic Neoplasms epidemiology, Colorectal Neoplasms, Hereditary Nonpolyposis prevention & control, Mass Screening
- Abstract
Purpose: Identification of the hereditary non-polyposis colorectal carcinoma syndrome (HNPCC) is a basis for secondary prevention. The objectives of this study are to investigate the natural history of HNPCC and to assess the effect of screening., Patients and Methods: Screening for colorectal carcinoma was performed in 22 HNPCC families (colonoscopy or double-contrast barium enema and sigmoidoscopy). The patients were subdivided into two groups. Group A comprised patients with colorectal cancer who were referred because they were symptomatic. Group B included family members of these patients who were found to have a colorectal lesion by screening. We compared these groups with respect to the stage of tumor growth., Results: Histologic examination of the tumors in Group A (87 patients) revealed Dukes A carcinomas in six patients, Dukes B carcinomas in 37, Dukes C carcinomas in 21, and Dukes D carcinomas in 10 patients (classification unknown in 13 patients). In Group B (20 patients), adenoma was found in 14 and carcinoma in six patients (Dukes A in two and Dukes B in four patients). A total of 93 patients, including those whose tumors were detected by screening, had a colorectal carcinoma. The age at diagnosis ranged from 24 to 81 years (mean age: 46 years). The location of the colonic tumors was proximal in 60 percent. Multiple primary tumors were found in 26 percent., Conclusion: These results suggest that screening leads to the early detection of colorectal carcinomas and adenomas in asymptomatic members of HNPCC families. Screening should be initiated at the age of 20 and continued during the life of the individual. Careful examination of the right colon is indicated because of the frequent occurrence of tumors in the proximal colon. A subtotal colectomy is indicated at the time of diagnosis of the initial colon cancer because of the risk of multiple primary tumors.
- Published
- 1989
- Full Text
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