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Ultrasound (US)‐mediated sonodynamic therapy (SDT) has emerged as a superior modality for cancer treatment owing to the non‐invasiveness and high tissue‐penetrating depth. However, developing biocompatible nanomaterial‐based sonosensitizers with efficient SDT capability remains challenging. Here, we employed a liquid‐phase exfoliation strategy to obtain a new type of two‐dimensional (2D) stanene‐based nanosheets (SnNSs) with a band gap of 2.3 eV, which is narrower than those of the most extensively studied nano‐sonosensitizers, allowing a more efficient US‐triggered separation of electron (e−)‐hole (h+) pairs for reactive oxygen species (ROS) generation. In addition, we discovered that such SnNSs could also serve as robust near‐infrared (NIR)‐mediated photothermal therapy (PTT) agents owing to their efficient photothermal conversion, and serve as nanocarriers for anticancer drug delivery owing to the inherent 2D layered structure. This study not only presents general nanoplatforms for SDT‐enhanced combination cancer therapy, but also highlights the utility of 2D SnNSs to the field of nanomedicine. [ABSTRACT FROM AUTHOR]

Keywords: combination cancer therapy; photothermal therapy; sonodynamic therapy; stanene; two-dimensional materials EN combination cancer therapy photothermal therapy sonodynamic therapy stanene two-dimensional materials 6829 6829 1 03/19/21 20210322 NES 210322 B 2D stanene-based nanosheets b (SnNSs) serving as a new type of sonosensitizer for ultrasound-mediated sonodynamic therapy are reported by Omid C. Farokhzad, Wei Tao, Tian Xie et al. in their Research Article on page 7155. Combination cancer therapy, photothermal therapy, sonodynamic therapy, stanene, two-dimensional materials Cover Picture: Stanene-Based Nanosheets for -Elemene Delivery and Ultrasound-Mediated Combination Cancer Therapy (Angew. [Extracted from the article]

GLO:OL3/22mar21:ange202101421-gra-0003.jpg PHOTO (COLOR): . gl B Computerchemie b DFT- und kMC-Rechnungen werden kombiniert, um die Reaktionsenergieprofile und die Bildungskinetik von Silika-Oligomeren zu untersuchen, wie Caroline Mellot-Draznieks, Carlos Nieto-Draghi et al. in ihrem Forschungsartikel auf S. 7187 beschreiben. Combination cancer therapy, photothermal therapy, sonodynamic therapy, stanene, two-dimensional materials Keywords: combination cancer therapy; photothermal therapy; sonodynamic therapy; stanene; two-dimensional materials EN combination cancer therapy photothermal therapy sonodynamic therapy stanene two-dimensional materials 6905 6905 1 03/23/21 20210322 NES 210322 B 2D-Nanoblätter b auf Stanen-Basis (SnNSs), die als neuartiger Sonosensibilisator für die ultraschallvermittelte sonodynamische Therapie dienen, werden von Omid C. Farokhzad, Wei Tao, Tian Xie et al. in ihrem Forschungsartikel auf S. 7231 vorgestellt. [Extracted from the article]

Biotite, also called black mica (BM), is a group of sheet silicate minerals with great potential in various fields. However, synthesis of high‐quality BM nanosheets (NSs) remains a huge challenge. Here, an exfoliation approach is provided that combines calcination, n‐butyllithium exchange and intercalation, and liquid exfoliating processes for the high‐yield synthesis of ultrathin BM NSs. Due to the presence of MgO, Fe2O3, and FeO in these NSs, PEGylated BM can be engineered as an intelligent theranostic platform with the following unique features: i) Fe3+ can damage the tumor microenvironment (TME) through glutathione consumption and O2 production; ii) Generated O2 can be further catalyzed by MgO with oxygen vacancy to generate ·O2−; iii) The Fe2+‐catalyzed Fenton reaction can produce ·OH by disproportionation reactions of H2O2 in the TME; iv) Reactions in (i) and (iii) circularly regenerate Fe2+ and Fe3+ for continuous consumption of glutathione and H2O2 and constant production of ·OH and O2; v) The NSs can be triggered by a 650 nm laser to generate ·O2− from O2 as well as by an 808 nm laser to generate local hyperthermia; and vi) The fluorescent, photoacoustic, and photothermal imaging capabilities of the engineered NSs allow for multimodal imaging‐guided breast cancer treatment. [ABSTRACT FROM AUTHOR]