1. Effect of B vitamins supplementation on cardio-metabolic factors in patients with stable coronary artery disease: A randomized double-blind trial.
- Author
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Man Liu, Zongling Wang, Shengxin Liu, Yizhi Liu, Yan Ma, Ying Liu, Meilan Xue, Qianqian Li, Xinqi Zhang, Sui Zhang, Hui Liang, Liu, Man, Wang, Zongling, Liu, Shengxin, Liu, Yizhi, Ma, Yan, Liu, Ying, Xue, Meilan, Li, Qianqian, and Zhang, Xinqi
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TRIGLYCERIDES , *HDL cholesterol , *RESEARCH , *RESEARCH methodology , *MEDICAL cooperation , *EVALUATION research , *VITAMIN B complex , *DIETARY supplements , *TREATMENT effectiveness , *COMPARATIVE studies , *RANDOMIZED controlled trials , *CORONARY artery disease , *BLIND experiment - Abstract
Background and Objectives: This study aimed to evaluate whether B vitamins supplementation would improve dyslipidemia, alleviate inflammatory state of patients with stable coronary artery disease (SCAD).Methods and Study Design: We conducted a randomized, double-blind, 12-week, placebo-controlled trial involving adults with SCAD, and who were randomly divided into B vitamins group (folic acid and VB-6) and control group (placebo tablet). Blood tests had also been performed at baseline and endpoint.Results: After 12 weeks of intervention, B vitamins supplementation significantly improved the concentration of serum TG, TC and HDL-C (p<0.05). Changes of serum homocysteine in B vitamins treatment were significantly different compared to placebo by the multivariate-adjusted analysis (3.02±2.35 vs 1.55±1.58 p<0.001). Meanwhile, the levels of IL-1β and IL-10, significant difference were observed between two groups after adjustment for confounding factors.Conclusions: Supplementation with B vitamins significantly improves lipid metabolism, alleviate inflammation and serum homocysteine concentration in patients with SCAD. [ABSTRACT FROM AUTHOR]- Published
- 2020
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