1. Studies on the phenylethanoid glycosides with anti-complement activity from Paulownia tomentosa var. tomentosa wood.
- Author
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Si CL, Deng XJ, Liu Z, Kim JK, and Bae YS
- Subjects
- Humans, Molecular Structure, Serum drug effects, Caffeic Acids chemistry, Caffeic Acids pharmacology, Complement Activation drug effects, Complement System Proteins metabolism, Disaccharides chemistry, Disaccharides pharmacology, Glycosides chemistry, Glycosides pharmacology, Scrophulariaceae chemistry
- Abstract
Four epimeric phenylethanoid glycosides, including a new one, R,S-beta-ethoxy-beta-(3,4-dihydroxyphenyl)-ethyl-O-alpha-L-rhamnopyranosyl(1-->3)-beta-D-(6-O-E-caffeoyl)-glucopyranoside named isoilicifolioside A (1), and three known compounds, ilicifolioside A (2), campneoside II (3), and isocampneoside II (4), were isolated from Paulownia tomentosa var. tomentosa wood. The structures of the four compounds were elucidated by the interpretation of 1D and 2D NMR and MS spectra. This is the first report of the chemical profile of this tree. Compounds 1-4 exhibited excellent anti-complement activity with IC(50) values less than 74 microM, compared with tiliroside (IC(50) = 104 microM) and rosmarinic acid (IC(50) = 182 microM) that were used as positive controls.
- Published
- 2008
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