1. Antiparasitic, Antineuroinflammatory, and Cytotoxic Polyketides from the Marine Sponge Plakortis angulospiculatus Collected in Brazil
- Author
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Manoel Odorico de Moraes, Bruno C. Cavalcanti, Noemi Nosomi Taniwaki, R. G. S. Berlinck, Antonio G. Ferreira, Katyuscya Veloso, Alejandro M. S. Mayer, Eduardo Hajdu, A. M. Nascimento, Claudia do Ó Pessoa, Andre G. Tempone, Miriam H. Kossuga, and Juliana Quero Reimão
- Subjects
Erythrocytes ,Antiparasitic ,medicine.drug_class ,Trypanosoma cruzi ,Antiprotozoal Agents ,Pharmaceutical Science ,Antineoplastic Agents ,Marine Biology ,Pharmacognosy ,Nitric Oxide ,Analytical Chemistry ,Mice ,Polyketide ,Cricetinae ,Plakortis ,parasitic diseases ,Drug Discovery ,medicine ,Animals ,Humans ,Leishmania infantum ,Cytotoxicity ,Pharmacology ,Mice, Inbred BALB C ,Mesocricetus ,Molecular Structure ,biology ,Traditional medicine ,Macrophages ,Anti-Inflammatory Agents, Non-Steroidal ,Organic Chemistry ,Leishmania chagasi ,biology.organism_classification ,Sponge ,Complementary and alternative medicine ,Biochemistry ,Molecular Medicine ,Macrolides ,Drug Screening Assays, Antitumor ,Neurogenic Inflammation ,Brazil - Abstract
Investigation of the bioactive crude extract from the sponge Plakortis angulospiculatus from Brazil led to the isolation of plakortenone ( 1) as a new polyketide, along with five known polyketides ( 2- 6) previously isolated from other Plakortis sponges. The known polyketides were tested in antileishmanial, antitrypanosomal, antineuroinflammatory, and cytotoxicity assays. The results show that plakortide P ( 3) is a potent antiparasitic compound, against both Leishmania chagasi and Trypanosona cruzi, and exhibited antineuroinflammatory activity. The known polyketides 2- 6 were tested for cytotoxicity against four human cancer cell lines, but displayed only moderate cytotoxic activity.
- Published
- 2008
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