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[Display omitted] • Fatigue crack growth analysis and investigation of failure criterion. • Simulation of self-heating and frictional heat under damage growth. • Simulation-Driven Dynamic Testing to investigate Multiphysics behaviour of fatigue. Structural integrity of aerospace assets is paramount for both the safety and economy of aviation industry. The introduction of composites into the design of aero-structures generated several economic benefits but also led to several challenges, including fatigue damage growth and self-heating behaviour. Fatigue of metals is widely managed by calculations of damage accumulation and prediction of residual life. These techniques do not always apply to the fatigue of composites, where the onset and propagation of damage are still under investigation. Furthermore, vibration-induced fatigue is even less understood because of a handful of failure criteria available and, also, because it is biased by the self-heating conditions of the material itself. The authors have underpinned one failure criterion for vibration fatigue and mapped that against self-heating and environmental temperatures. Despite the advances, several research questions were left open because of the complex multiphysics behaviour of fatigue which outreached the experimental capacity. Therefore, this research suggests a Simulation-Driven Dynamic Test (SDDT) framework that deconstructs vibration fatigue experiments into step-wise steady-state analyses. This novel approach will enable (a) investigating the failure mode mixity of the underlying failure criterion, and (b) simulating the surface temperature during the delamination growth under vibration conditions. [ABSTRACT FROM AUTHOR]