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About 70% of all collective doses from medical tests come from computed tomography (CT), the primary public radiation exposure source. Patients received higher doses during contrast-enhanced CT procedures (Angiography) than routine CT procedures. The current research aims to quantify the patients' radiation doses, estimate the cancer risk probability, and establish institutional diagnostic reference level (IDRL) during lower extremity angiography. One hundred eleven patients (61.3% male and 38.7% female) underwent contrast-enhanced CT procedures. A 160-Slice CT scanner was used for image acquisition for all patient populations. IDRL values were quantified based on the 3rd quartile value of the CT dose descriptors. All procedures were carried out at Al-Moaallim Medical City, Khartoum, Sudan. A computer software (CT-Expo, ImPACT) was used to extrapolate the effective dosage per extremity CTA examination was estimated. The mean patient age (years) was 56.1 ± 18 (18–82). The patient's radiation doses was quantified using volume CTDI and dose length product (DLP) to 7.3 ± 2 (2.9–16.8) (mGy) and 3712 ± 126 (279–8374) (mGy.cm), respectively. The average effective doses were 22 mSv (range: 1.7–50) per lower CT angiography for the lower extremity. The proposed IDRL for the VCTA procedure was 3562 mGy cm and 17 mGy for DLP and CTDIvol, respectively. The proposed IDRL is higher than the previously published studies; therefore, patient dose optimization is recommended. • Radiation doses were determined for patients undergoing VCTA procedure. • A 160-Slice CT scanner with iterative reconstruction techniques was used for examining the patients. • The average effective doses were 22 mSv (range: 1.7–50) per VCTA. • The proposed LDRL for the VCTA procedure was 3562 mGy cm and 17 mGy for DLP and CTDIvol, respectively. [ABSTRACT FROM AUTHOR]

Renal diseases and urinary tract disorders are causing a global burden, with an estimated prevalence of around 13%. Contrast-enhanced computed tomography urography (CE-CTU) is a well-known diagnostic technique for urinary system diseases for initial diagnosis and, very often, for follow-up. CE-CTU procedure exposes patients to high doses of ionizing radiation; hence, justification and optimization of doses are necessary to maximize the benefits and minimize the patients' risks. This study aims to evaluate radiation doses to patients during CE-CTU procedures and estimate the subsequent radiogenic risk. The study included twenty-seven patients who underwent CE-CTU examination in two different hospitals (National Ribat Hospital (NRH) and National Security Fource Hospital (NSFH)), where 16-slice CT machines from different vendors are used. The variables and significance were analyzed using SPSS and Scheffe's statistical tool. Data collected included the age of patients (19–70 years), the radiation dose received by patients: dose length product (DLP, mGy.cm) and volume CT dose index (CTDIvol (mGy)), and tube current-time product (mAs). Patients' dose measurements per CE-CTU procedure given as (mean and range) was: DLP 3098 (647–5301) (mGy.cm) and CTDIvol 44.11 (15–136) (mGy). The results revealed statistically significant differences in DLP (mGy.cm), CTDIvol (mGy), and mAs, and this could be attributed to discrepancies in protocols, machines, and operators among the hospitals and within each hospital. Considering gender, the variables (age, tube current-time product (mAs), and CTDIvol) showed no statistically significant differences. The radiogenic risks from the CE-CTU procedure were ≈1 per 400. Comparison between the two hospitals showed that the variables varied significantly between the hospitals studied, but no significant differences were found based on gender. CE-CTU with contrast medium exposes patients to high doses. Therefore, proper dose optimization is crucial. • The radiation doses during IVU and the subsequent risks from exposure are studied. • The entrance-surface air kerma (ESAK) and effective dose were quantified. • Calculation of the overall cancer risk yielded 5.85 per million procedures. • The effective and cancer risk are around ten times lower during IVU procedures compared to CTU. [ABSTRACT FROM AUTHOR]

Mammary glands or breasts are radiosensitive organs that makeup 12% of the body's overall radiation sensitivity. According to estimates, Saudi Arabia has a 27.3% overall cancer incidence rate for breast cancer. Recent studies reported that breasts get significant organ equivalent doses during diagnostic procedures with ionizing radiation, even though the breast is not the target organ. The objective of this work is to assess the effective and breast equivalent doses during positron emission tomography (PET)/Computed tomography (CT) imaging examinations. The effective and breast equivalent doses per PET/CT (GE PET/CT 710) examination were quantified using the amount of the injected radiopharmaceutical (MBq) (18F- fluorodeoxyglucose (FDG)), and external doses from CT examinations. The average, standard deviation (SD) and range of examined patients' age (years) and body mass index ((BMI), kg/m2) were 58 ± 11 (39–76) and 30 ± 5 (20.7–43.1), respectively. Constant administered activity (AA, 185 MBq) and tube potential (120 kVp) were used for all patients. The average, SD, and range of the patients effective dose (mSv) from PET/CT (18F- FDG) examination was 8.0 ± 0.93 (7.0–10.0) and 2.075 ± 0.11 (1.91–2.29) in that order. Breast doses are comparable with previous studies during the PET/CT and mammographic examination. Proper justification criteria and dose optimization are essential to lowering excessive exposure while preserving image quality, especially for young females because they have a higher risk of radiation-induced cancer. • Breast doses during PET/CT imaging procedures were evaluated. • Breast absorbed dose depends on CT protocol and administered activity. • The organ equivalent dose ranged from 1.91 to 2.29 mGy per procedure. • Breast doses are comparable with previous studies PET/CT procedures. • Young females have a higher risk of breast cancer due to PET/CT procedure. [ABSTRACT FROM AUTHOR]

The pathology of the urinary system is usually investigated using Intravenous Urography (IVU). The study objectives are to quantify patients' radiation dose and radiation induced malignant tumors risk during IVU examination. The radiation doses during IVU and the subsequent risks from exposure are studied, using data from 50 patients imaged in one hospital. The demographic data given as (mean ± std) was as follows:The age of patients was 39 ± 14 years; height of patients was 1.7 ± 0.1 m, the mass was 69 ± 10 kg and the body-mass-index was 24.3 ± 4.1 kg m−2. The physical exposure parameters recorded were: kVp: 74.04 ± 3.1, mAs: 33.64 ± 4. Moreover, the average number of films per procedure was 5.72 ± 1.49. The entrance-surface air kerma (ESAK) was 2.1 ± 0.64 mGy, and the mean effective dose was 0.131 ± 0.04 mSv. Calculation of the overall cancer risk yielded 5.9 × 10−6 procedures. ESAK (mGy) and effective dose values obtained in this study were comparable with reported studies as shown in the text. The effective and cancer risk are around ten times lower during IVU procedures than for example, contrast enhanced computed tomography urography (CTU) examination. Reduction of doses received by patients to meet the values of the diagnostic reference levels without compromising the quality and clarity of the images is highly recommended. Radiation dosimetry; IVU; Radiology; Cancer risk; medical imaging. • The radiation doses during IVU and the subsequent risks from exposure are studied. • The entrance-surface air kerma (ESAK) and effective dose were quantified. • Calculation of the overall cancer risk yielded 5.85 per million procedures. • Patients received higher doses due to unoptimized imaging protocol. [ABSTRACT FROM AUTHOR]

The objective of this study is to assess the patients' effective and organ dose during theranostic applications in Kuwait. In total, eighteen adults' patients were conducted nuclear medicine procedures with 177Lu Dotatate for theranostic purpose in Kuwait Cancer control center (KCCC), Kuwait. Medium energy collimator (MEC) (208 keV Scatter 26% better than 113 keV Scatter 60%) was utilized to obtain scans in definite time intervals ranged from one to 2 h (before voiding), 6:00, 24:00, 48:00, 72:00 h. Patients, tissue and organ radiation doses were computed utilizing OLINDA/EXM Software. The average radiation effective dose (in mSv/MBq) for bladder, liver, and both kidneys (left & right), were 0.36, 0.08, 0.61 & 0.60. The range of the effective dose was from 0.55 mSv to 7.7 mSv. The acquired scans using 177Lu were delivered diagnostic findings. The patients' effective dose is lower compared to the previous studies. Variation is attributed to the departmental protocol and administered activity. The values of the mean organ dose were comparable and lower than previously published studies. Different organs have different level of doses, which may affected by the presence of the metastatic tumors in the entire organ. • Patients' organs dosimetry in targeted radionuclide therapy were carried out in Kuwait Cancer Control Centre. • A total of 18 patients were undergone theranostic procedures with 177Lu Dotatate. • Organ and total patients doses were calculated using Organ Level INternal Dose Assessment (OLINDA) Software. • Optimization of the PET/CT imaging protocol is recommended to assure that patients received a minimal effective dose. [ABSTRACT FROM AUTHOR]

The positron emitters (18F-Sodium Fluoride (NaF)) and X-rays used in Positron emission tomography (PET) combined with computed tomography (PET/CT) imaging have a high radiation dose, which results in a high patient dose. The present research intends to determine the radiation dose and risks associated with PET/CT- 18F-Sodium fluoride examinations in patients. The 18F–NaF PET/CT was used to investigate the doses of 86 patients. Patient exposure parameters and ImPACT software were used to calculate mean effective doses. The administered activity of 185 MBq (5.0 mCi) per procedure has a mean and range based on the patient's BMI (BMI). The range of patient effective doses per procedure was found to be 4–10 mSv, with a radiation risk of 1 × 10−5 per procedure. Patient doses are determined by the patient's size, scanner type, imaging protocol, and reconstruction method. For further dose reduction, proper justification and radiation dose optimization is required. • Effective doses were estimated for patients undergoing PET/CT procedures. • CT contributed 66.7% to patient cumulative effective doses (mSv) while (18F–NaF, PET) contributed 33.3%. • Patients dose optimization is recommended during PET/CT examinations. [ABSTRACT FROM AUTHOR]

Computed tomography (CT) has become a prominent source of medical exposures, conduct requiring measures that mitigate radio carcinogenic risk and deterministic tissue reaction effects. The objective of present study, conducted in Sudan, has been to evaluate patient radiogenic risk during vascular CT procedures. Study was made of 485 patients, the cohort comprising 218 males (45%) and 267 females (55%) of mean age ± 1 s.d. of 48.2 ± 17 years (ranging from 18.0 to 93.0 years). The investigation involved nine radiology departments, covering three different CT modalities (16, 64 and 128 slice). Patient organ and effective doses were estimated using established computer software (specifically, CT-Expo, ImPACT and that of the NRPB). The range of patient dose in terms of dose length product (DLP) (mGy.cm) and volume CT dose index (CTDI vol (mGy) were 3.2–28.51 mGy and 257.0–9263.5, respectively. The mean and range of effective dose were 25.5 ± 18 mSv and 4.0–138.9 mSv respectively. The wide range of doses indicates the likelihood that patients have been receiving avoidable radiation exposure, their being potential for mitigation of cancer incidence risk through further optimisation of procedures. On the basis of present study of vascular CT procedure doses, the mean risk of carcinogenesis has been estimated to be 1 in 1000 procedures. • Patients radiation doses were evaluated during vascular CT procedures for various CT modalities. • Effective dose were estimated using computer software. • The wide range of observed patient doses indicates patients to have been receiving avoidable radiation exposure. • The mean risk of carcinogenesis has been estimated to be 1 in 1000 procedures. [ABSTRACT FROM AUTHOR]