1. Posterior fossa primary intracranial extraosseous Ewing's sarcoma: case report.
- Author
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Shah, Shariq Ahmad, Charan, Bheru Dan, Agarwal, Sushant, Das, Sumanta, Singh, Pankaj Kumar, Sebastian, Leve Joseph Devaranjan, and Garg, Ajay
- Subjects
INTRACRANIAL hemorrhage ,DIFFERENTIAL diagnosis ,DIAGNOSTIC imaging ,RARE diseases ,ADJUVANT treatment of cancer ,COMPUTED tomography ,INFRATENTORIAL brain tumors ,NEUROECTODERMAL tumors ,HEAD ,CHEMORADIOTHERAPY ,MAGNETIC resonance imaging ,CRANIOTOMY ,INFANT nutrition ,IMMUNOHISTOCHEMISTRY ,FLUORESCENCE in situ hybridization ,EWING'S sarcoma ,NEURORADIOLOGY ,VOMITING ,BRAIN tumors ,CONTRAST media ,GENETIC testing - Abstract
Background: Primary intracranial Ewing's sarcoma (ES) is a type of primitive neuroectodermal tumour and is a rare malignant tumour in children and adolescents. The imaging features of ES overlap with other central nervous system embryonal tumours, making it difficult to pinpoint a specific diagnosis. We aim to explore the clinical, neuroimaging and differential diagnoses of this entity. Case presentation: We describe a 6-month-old infant who presented with complaints of enlarging the head size and poor feeding. Imaging revealed a contrast-enhancing large solid-cystic mass lesion with internal calcification, focal bone erosion and haemorrhage in the posterior fossa. Histopathological examinations, immunohistochemistry, and molecular analysis confirmed ES. Conclusions: The confirmative diagnosis of primary intracranial ES requires histological examination, immunohistochemical analysis, and genetic detection, along with radiological findings. Surgical excision followed by combined radiotherapy and chemotherapy is the treatment of choice. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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