20 results on '"Lijuan Zhang"'
Search Results
2. Iodine-125 seed implantation for residual hepatocellular carcinoma or cholangiocellular carcinoma in challenging locations after transcatheter arterial chemoembolization. Initial experience and findings
- Author
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Jie Li, Lijuan Zhang, Zongqiong Sun, Yuxi Ge, Han Xiao, Qigen Xie, and Shudong Hu
- Subjects
liver neoplasms ,iodine-125 ,computed tomography ,neoplasm ,residual ,chemoembolization ,therapeutic ,Medicine - Published
- 2020
- Full Text
- View/download PDF
3. Three-dimensional ultrastructural imaging reveals the nanoscale architecture of mammalian cells
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Shengkun Yao, Jiadong Fan, Zhiyun Chen, Yunbing Zong, Jianhua Zhang, Zhibin Sun, Lijuan Zhang, Renzhong Tai, Zhi Liu, Chunying Chen, and Huaidong Jiang
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cellular imaging ,X-ray tomography ,equally sloped tomography ,dual-energy contrast ,computed tomography ,nanoscience ,X-ray microscopy ,imaging ,structure determination ,Crystallography ,QD901-999 - Abstract
Knowledge of the interactions between nanomaterials and large-size mammalian cells, including cellular uptake, intracellular localization and translocation, has greatly advanced nanomedicine and nanotoxicology. Imaging techniques that can locate nanomaterials within the structures of intact large-size cells at nanoscale resolution play crucial roles in acquiring this knowledge. Here, the quantitative imaging of intracellular nanomaterials in three dimensions was performed by combining dual-energy contrast X-ray microscopy and an iterative tomographic algorithm termed equally sloped tomography (EST). Macrophages with a size of ∼20 µm that had been exposed to the potential antitumour agent [Gd@C82(OH)22]n were investigated. Large numbers of nanoparticles (NPs) aggregated within the cell and were mainly located in phagosomes. No NPs were observed in the nucleus. Imaging of the nanomedicine within whole cells advanced the understanding of the high-efficiency antitumour activity and the low toxicity of this agent. This imaging technique can be used to probe nanomaterials within intact large-size cells at nanometre resolution uniformly in three dimensions and may greatly benefit the fields of nanomedicine and nanotoxicology.
- Published
- 2018
- Full Text
- View/download PDF
4. Computed tomography-guided implantation of 125 I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results
- Author
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Jie Li, Lijuan Zhang, Wenhuan Xu, Teng Wang, Leyuan Zhou, Qigen Xie, Weiguo Wang, and Yanyan Hua
- Subjects
brachytherapy ,computed tomography ,125I ,pulmonary metastatic tumors ,Medicine - Abstract
Purpose : To retrospectively evaluate the efficacy and safety of computed tomography (CT)-guided percutaneous interstitial brachytherapy using 125 I radioactive seeds for multiple pulmonary metastatic tumors. Material and methods : Between September 2013 and December 2015, 22 patients with multiple pulmonary metastases, who after conventional chemotherapy and trans-arterial chemoembolization (TACE) therapy were considered unable to withstand stereotactic body radiation therapy (SBRT), received CT-guided 125 I brachytherapy. Clinical data were studied retrospectively. A planning target volume of 90% (D90) was 120-160 Gy for 125 I seeds with an activity of 25.9 MBq. A CT-based evaluation performed 1, 2, and 6 months’ post-implantation enabled review of local control of tumors. Results : Twenty-two patients with 65 pulmonary metastases successfully completed treatment. The mean value for D90 for implantation for 125 I seeds was 132 Gy. Complete response (CR) + partial response (PR) was documented in 81.54%, 78.46%, and 78.46% of patients at 1, 2, and 6 months after implantation, respectively. Fourteen out of 22 patients had CR, 3 had PR, 2 had stable disease (SD), and 3 had progressive disease (PD). Most of the metastases (CR + PR + SD; 87.69% after 6 months) were controlled by implantation. Conclusions : CT-guided 125 I brachytherapy is a safe and effective treatment for multiple pulmonary metastatic tumors, and can achieve good short-term local control, so long as the radiation dose is sufficient.
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- 2017
- Full Text
- View/download PDF
5. Hemangioma Mimicking Left Atrial Mass in the Posterior Mediastinum
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Shuzhen Wang, Min Xu, Feng Xiong, and Lijuan Zhang
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medicine.medical_specialty ,Left atrial mass ,medicine.diagnostic_test ,business.industry ,Radiography ,Mediastinum ,Computed tomography ,Magnetic resonance imaging ,General Medicine ,medicine.disease ,Asymptomatic ,respiratory tract diseases ,body regions ,Hemangioma ,medicine.anatomical_structure ,medicine ,Radiology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Posterior mediastinum - Abstract
Primary hemangioma of the mediastinum is extremely rare. Herein, we present a unique case of hemangioma mimicking left atrial mass in the posterior mediastinum. We reviewed the literature and found 17 other hemangiomas in the posterior mediastinum. Herein, we summarize the age, gender, symptoms, diagnostic methods, image diagnosis, size, treatments, histologic features, outcomes, and follow-up of 17 cases. Most of the cases were asymptomatic and were accidentally detected in chest radiographs. Diagnostic methods mainly included chest X-ray, computed tomography (CT), and magnetic resonance imaging (MRI). All patients underwent surgical resection, recovered well, and had no recurrence during follow-up.
- Published
- 2021
6. Iodine-125 seed implantation treatment of lung metastases < 2.5 cm using 5-ml syringe as a guide
- Author
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Jialiang Zhou, Qigen Xie, Yuxi Ge, Lijuan Zhang, Jie Li, and Zongqiong Sun
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0106 biological sciences ,medicine.medical_specialty ,medicine.medical_treatment ,brachytherapy ,Brachytherapy ,lung neoplasms ,anesthesia ,Chest pain ,01 natural sciences ,neoplasm metastasis ,iodine-125 ,Medicine ,Radiology, Nuclear Medicine and imaging ,Local anesthesia ,Syringe ,Original Paper ,Lung ,business.industry ,010401 analytical chemistry ,computed tomography ,Retrospective cohort study ,Seed Implantation ,0104 chemical sciences ,Surgery ,medicine.anatomical_structure ,Oncology ,Sputum ,medicine.symptom ,business ,010606 plant biology & botany - Abstract
Purpose Small lung metastases change their location with respiration, making difficult to localize, therefore, increasing the number of punctures. Accurate puncture can reduce trauma to lung tissue and accelerate patient’s recovery. The aim of the study was to present our experience with the technique of using local anesthesia 5-ml syringe as a guide for computerized tomography-guided iodine-125 seed implantation (CT-ISI). Material and methods This was a retrospective study, including patients with small metastatic tumors in the lung, treated with CT-ISI between December 2013 and March 2018 at the Affiliated Hospital of the University. The patients were divided according to whether a 5-ml syringe was used as a guide during CT-ISI or not. The final follow-up was on March 31st, 2018. Implantation success and complications were examined. Results Nineteen patients were included. A total of 840 seeds were used, with 44.2 ±33.6 (range, 10-160) seeds per patient. The mean D90 for CT-ISI was 134.5 ±7.5 Gy. Treatment intervention for eleven patients was performed using a 5-ml syringe as a guide during CT-ISI. There were no differences in total dose and number of implanted seeds between the two groups, but the number of punctures per lesion was lower in the syringe group than in the no-syringe group (1.9 ±0.5 vs. 2.9 ±0.6, p < 0.001), suggesting a higher puncture accuracy. The total number of SMTIL was 50 (median, 2; range, 1-10), and the median size was 1.9 cm (range, 0.8-2.4 cm). All SMTIL were well-controlled at 6-months follow-up (response rate [RR] = 100%). One patient in the no-syringe group experienced grade 2 chest tightness, chest pain, intraoperative needle tract bleeding, and post-operative blood in sputum. Conclusions Puncture with a 5-ml syringe as a guide during CT-ISI seems to be a more accurate option for patients with small (< 2.5 cm) lung metastasis.
- Published
- 2020
7. Iodine-125 seed implantation for residual hepatocellular carcinoma or cholangiocellular carcinoma in challenging locations after transcatheter arterial chemoembolization. Initial experience and findings
- Author
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Yuxi Ge, Shudong Hu, Han Xiao, Qigen Xie, Zongqiong Sun, Lijuan Zhang, and Jie Li
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0106 biological sciences ,medicine.medical_specialty ,medicine.medical_treatment ,Brachytherapy ,Hilum (biology) ,Computed tomography ,01 natural sciences ,residual ,iodine-125 ,Medicine ,Radiology, Nuclear Medicine and imaging ,Transcatheter arterial chemoembolization ,chemoembolization ,Original Paper ,liver neoplasms ,medicine.diagnostic_test ,business.industry ,010401 analytical chemistry ,computed tomography ,Seed Implantation ,medicine.disease ,0104 chemical sciences ,Diaphragm (structural system) ,therapeutic ,Oncology ,Cholangiocellular carcinoma ,Hepatocellular carcinoma ,Radiology ,business ,neoplasm ,010606 plant biology & botany - Abstract
Purpose To evaluate the clinical efficacy and safety of computed tomography (CT)-guided iodine-125 (125I) seed implantation (ISI) for hepatocellular carcinoma (HCC) or cholangiocellular carcinoma (CCC) lesions in challenging locations after transcatheter arterial chemoembolization (TACE). Material and methods A retrospective single-center review of 24 patients with HCC or CCC tumors in challenging locations (hepatic dome or close to the heart/diaphragm/hepatic hilum) was conducted. Patients who underwent CT-guided 125I implantation from May 2014 to January 2019 were recruited. Patients' demographics and details including technical success, treatment response, patient survival, and complication rate were also evaluated. Results Treated tumors were located in the hepatic dome (n = 10; 41.7%), subcapsularly (n = 6; 25%), close to the heart (n = 3; 12.5%), and in the liver hilum (n = 5; 20.8%). The mean maximum diameter of tumors in challenging locations was 40.08 ±11.34 mm (range, 25-68 mm). TACE (2 ±1, 1-4 times) was applied before ISI. There were 27 ISI treatments administered (3 patients also received supplemental ISI). The total number of implanted seeds was 1,160, with mean 48 ±16 seed per patient (range, 30-90 seeds). The mean D90 value for ISI was 125 Gy. Technical success rate was 100%, while a complete response + partial response (CR + PR) was documented in 70.83%, 79.17%, 83.33%, and 79.17% of patients at 3, 6, 12, and 24 months post-ISI, respectively. There were no major complications, although 2 cases experienced 125I seed transfer to the diaphragm, and 1 case experienced transfer to the heart cavity. Conclusions CT-guided ISI for HCC or CCC lesions in challenging locations after TACE is both highly effective and safe.
- Published
- 2020
8. Three-dimensional ultrastructural imaging reveals the nanoscale architecture of mammalian cells
- Author
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Jianhua Zhang, Zhibin Sun, Jiadong Fan, Huaidong Jiang, Zhiyun Chen, Chunying Chen, Yunbing Zong, Lijuan Zhang, Shengkun Yao, Zhi Liu, and Renzhong Tai
- Subjects
0301 basic medicine ,Nanoparticle ,Biochemistry ,Nanomaterials ,03 medical and health sciences ,Microscopy ,cellular imaging ,General Materials Science ,X-ray microscopy ,lcsh:Science ,Instrumentation ,Nanoscopic scale ,equally sloped tomography ,Chemistry ,imaging ,computed tomography ,General Chemistry ,nanoscience ,Condensed Matter Physics ,Research Papers ,structure determination ,030104 developmental biology ,Nanotoxicology ,Ultrastructure ,Biophysics ,Nanomedicine ,lcsh:Q ,dual-energy contrast ,X-ray tomography ,Intracellular - Abstract
A single-cell imaging technique has been demonstrated by combining dual-energy contrast X-ray microscopy and an iterative tomographic algorithm called equally sloped tomography. The technique can simultaneously observe cellular ultrastructures and nanomaterial distributions., Knowledge of the interactions between nanomaterials and large-size mammalian cells, including cellular uptake, intracellular localization and translocation, has greatly advanced nanomedicine and nanotoxicology. Imaging techniques that can locate nanomaterials within the structures of intact large-size cells at nanoscale resolution play crucial roles in acquiring this knowledge. Here, the quantitative imaging of intracellular nanomaterials in three dimensions was performed by combining dual-energy contrast X-ray microscopy and an iterative tomographic algorithm termed equally sloped tomography (EST). Macrophages with a size of ∼20 µm that had been exposed to the potential antitumour agent [Gd@C82(OH)22]n were investigated. Large numbers of nanoparticles (NPs) aggregated within the cell and were mainly located in phagosomes. No NPs were observed in the nucleus. Imaging of the nanomedicine within whole cells advanced the understanding of the high-efficiency antitumour activity and the low toxicity of this agent. This imaging technique can be used to probe nanomaterials within intact large-size cells at nanometre resolution uniformly in three dimensions and may greatly benefit the fields of nanomedicine and nanotoxicology.
- Published
- 2018
9. Computed tomography-guided implantation of 125 I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results
- Author
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Weiguo Wang, Yanyan Hua, Qigen Xie, Lijuan Zhang, Wenhuan Xu, Jie Li, Leyuan Zhou, and Teng Wang
- Subjects
medicine.medical_specialty ,Percutaneous ,Stereotactic body radiation therapy ,medicine.medical_treatment ,brachytherapy ,Brachytherapy ,Planning target volume ,lcsh:Medicine ,Computed tomography ,030218 nuclear medicine & medical imaging ,pulmonary metastatic tumors ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Effective treatment ,Radiology, Nuclear Medicine and imaging ,medicine.diagnostic_test ,business.industry ,lcsh:R ,computed tomography ,medicine.disease ,125I ,Oncology ,030220 oncology & carcinogenesis ,Conventional chemotherapy ,Radiology ,business ,Nuclear medicine ,Progressive disease - Abstract
Purpose : To retrospectively evaluate the efficacy and safety of computed tomography (CT)-guided percutaneous interstitial brachytherapy using 125 I radioactive seeds for multiple pulmonary metastatic tumors. Material and methods : Between September 2013 and December 2015, 22 patients with multiple pulmonary metastases, who after conventional chemotherapy and trans-arterial chemoembolization (TACE) therapy were considered unable to withstand stereotactic body radiation therapy (SBRT), received CT-guided 125 I brachytherapy. Clinical data were studied retrospectively. A planning target volume of 90% (D90) was 120-160 Gy for 125 I seeds with an activity of 25.9 MBq. A CT-based evaluation performed 1, 2, and 6 months’ post-implantation enabled review of local control of tumors. Results : Twenty-two patients with 65 pulmonary metastases successfully completed treatment. The mean value for D90 for implantation for 125 I seeds was 132 Gy. Complete response (CR) + partial response (PR) was documented in 81.54%, 78.46%, and 78.46% of patients at 1, 2, and 6 months after implantation, respectively. Fourteen out of 22 patients had CR, 3 had PR, 2 had stable disease (SD), and 3 had progressive disease (PD). Most of the metastases (CR + PR + SD; 87.69% after 6 months) were controlled by implantation. Conclusions : CT-guided 125 I brachytherapy is a safe and effective treatment for multiple pulmonary metastatic tumors, and can achieve good short-term local control, so long as the radiation dose is sufficient.
- Published
- 2017
10. Facile assembling of novel polypyrrole nanocomposites theranostic agent for magnetic resonance and computed tomography imaging guided efficient photothermal ablation of tumors
- Author
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Lijuan Zhang, Qiugeng Wang, Xijian Liu, Dawei Yan, Haikuan Yuan, Guoying Deng, and Jie Lu
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Materials science ,Biocompatibility ,Polymers ,Nanoparticle ,Contrast Media ,Computed tomography ,Nanotechnology ,02 engineering and technology ,Mice, SCID ,engineering.material ,010402 general chemistry ,Polypyrrole ,01 natural sciences ,Theranostic Nanomedicine ,Nanocomposites ,Biomaterials ,chemistry.chemical_compound ,Colloid and Surface Chemistry ,Coating ,Neoplasms ,medicine ,Human Umbilical Vein Endothelial Cells ,Animals ,Humans ,Pyrroles ,Nanocomposite ,medicine.diagnostic_test ,Magnetic resonance imaging ,Hyperthermia, Induced ,Photothermal therapy ,Phototherapy ,021001 nanoscience & nanotechnology ,Magnetic Resonance Imaging ,Ferrosoferric Oxide ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,chemistry ,engineering ,Gold ,0210 nano-technology ,Tomography, X-Ray Computed ,HeLa Cells - Abstract
Multifunctional nanocomposites for image-guided cancer therapy are highly desired in clinical application. Herein, a novel theranostic agent based on gold and ferroferric oxide nanoparticles coating polypyrrole particles (PPy@Fe3O4/Au nanocomposites) for computed tomography (CT) and magnetic resonance (MR) imaging guided photothermal therapy was successfully assembled by a very facile electrostatic adsorption method. PPy@Fe3O4/Au nanocomposites exhibit good biocompatibility in vitro and in vivo. Because of high r2 relaxivity of Fe3O4 and high X-ray attenuation ability of Au, the PPy@Fe3O4/Au nanocomposites exhibited desirable CT and MR imaging performance, which provide more comprehensive and accurate diagnostic information. Moreover, PPy@Fe3O4/Au nanocomposites can efficiently kill cancer cells by hyperthermia with the guiding of CT and MR imaging, even completely ablate tumours. Hence, the electrostatic adsorption assembled PPy@Fe3O4/Au nanocomposites have great potential in clinical application for diagnosing and treating tumour in the future.
- Published
- 2018
11. Blend Sign on Computed Tomography
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Mei-Xue Dong, Lijuan Zhang, Peng Xie, Yuan-Jun Huang, Xinyue Qin, Jianjun Chen, Gang Zhang, Xiao Wei, Qi Li, and Fajin Lv
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Adult ,Hematoma, Epidural, Cranial ,Male ,medicine.medical_specialty ,Computed tomography ,Computed tomographic ,Hematoma ,Predictive Value of Tests ,medicine ,Medical imaging ,Humans ,In patient ,Stroke ,Aged ,Cerebral Hemorrhage ,Aged, 80 and over ,Advanced and Specialized Nursing ,Intracerebral hemorrhage ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,Middle Aged ,medicine.disease ,Early Diagnosis ,Female ,Neurology (clinical) ,Radiology ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies ,Sign (mathematics) - Abstract
Background and Purpose— Early hematoma growth is not uncommon in patients with intracerebral hemorrhage and is an independent predictor of poor functional outcome. The purpose of our study was to report and validate the use of our newly identified computed tomographic (CT) blend sign in predicting early hematoma growth. Methods— Patients with intracerebral hemorrhage who underwent baseline CT scan within 6 hours after onset of symptoms were included. The follow-up CT scan was performed within 24 hours after the baseline CT scan. Significant hematoma growth was defined as an increase in hematoma volume of >33% or an absolute increase of hematoma volume of >12.5 mL. The blend sign on admission nonenhanced CT was defined as blending of hypoattenuating area and hyperattenuating region with a well-defined margin. Univariate and multivariable logistic regression analyses were performed to assess the relationship between the presence of the blend sign on nonenhanced admission CT and early hematoma growth. Results— A total of 172 patients were included in our study. Blend sign was observed in 29 of 172 (16.9%) patients with intracerebral hemorrhage on baseline nonenhanced CT scan. Of the 61 patients with hematoma growth, 24 (39.3%) had blend sign on admission CT scan. Interobserver agreement for identifying blend sign was excellent between the 2 readers (κ=0.957). The multivariate logistic regression analysis demonstrated that the time to baseline CT scan, initial hematoma volume, and presence of blend sign on baseline CT scan to be independent predictors of early hematoma growth. The sensitivity, specificity, positive and negative predictive values of blend sign for predicting hematoma growth were 39.3%, 95.5%, 82.7%, and 74.1%, respectively. Conclusions— The CT blend sign could be easily identified on regular nonenhanced CT and is highly specific for predicting hematoma growth.
- Published
- 2015
12. Computed tomography-guided implantation of
- Author
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Jie, Li, Lijuan, Zhang, Wenhuan, Xu, Teng, Wang, Leyuan, Zhou, Qigen, Xie, Weiguo, Wang, and Yanyan, Hua
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Original Paper ,pulmonary metastatic tumors ,brachytherapy ,125I ,computed tomography - Abstract
Purpose To retrospectively evaluate the efficacy and safety of computed tomography (CT)-guided percutaneous interstitial brachytherapy using 125I radioactive seeds for multiple pulmonary metastatic tumors. Material and methods Between September 2013 and December 2015, 22 patients with multiple pulmonary metastases, who after conventional chemotherapy and trans-arterial chemoembolization (TACE) therapy were considered unable to withstand stereotactic body radiation therapy (SBRT), received CT-guided 125I brachytherapy. Clinical data were studied retrospectively. A planning target volume of 90% (D90) was 120-160 Gy for 125I seeds with an activity of 25.9 MBq. A CT-based evaluation performed 1, 2, and 6 months’ post-implantation enabled review of local control of tumors. Results Twenty-two patients with 65 pulmonary metastases successfully completed treatment. The mean value for D90 for implantation for 125I seeds was 132 Gy. Complete response (CR) + partial response (PR) was documented in 81.54%, 78.46%, and 78.46% of patients at 1, 2, and 6 months after implantation, respectively. Fourteen out of 22 patients had CR, 3 had PR, 2 had stable disease (SD), and 3 had progressive disease (PD). Most of the metastases (CR + PR + SD; 87.69% after 6 months) were controlled by implantation. Conclusions CT-guided 125I brachytherapy is a safe and effective treatment for multiple pulmonary metastatic tumors, and can achieve good short-term local control, so long as the radiation dose is sufficient.
- Published
- 2016
13. Feasibility of three-dimensional-printed template-guided 125I seed brachytherapy and dosimetric evaluation in patients with malignant tumor
- Author
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Zezhou Liu, Xiaoli Liu, Jinxin Zhao, Aixia Sui, Xuemin Di, Devjoy Dev, Lijuan Zhang, Hongtao Zhang, Juan Wang, Yansong Liang, Man Hu, and Huimin Yu
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0301 basic medicine ,125I isotopes ,medicine.medical_treatment ,brachytherapy ,Brachytherapy ,Planning target volume ,Computed tomography ,lcsh:RC254-282 ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,In patient ,three-dimensional-printed ,medicine.diagnostic_test ,business.industry ,Significant difference ,template ,General Medicine ,125i seed ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,030104 developmental biology ,Oncology ,Volume Percentage ,radiation dosage ,030220 oncology & carcinogenesis ,Absorbed dose ,Nuclear medicine ,business - Abstract
Objective: The objective of the study is to test whether three-dimensional (3D)-printed template can be used reproducibly for guiding malignant tumors brachytherapy and study the dosimetric consistency and adequacy between pre- and post-plan. Materials and Methods: Between January and December 2016 in our hospital, a total of 14 patients underwent 3D-printed template-guided brachytherapy. All the patients were fixed into position using a vacuum cushion before undertaking a computed tomography (CT) scan. After the preplan was designed, the templates were printed. The tumors were punctured through predesigned needle holes. Following this, another CT scan was used to confirm the locations of needles, and then the 125 I radioactive seeds were implanted into the tumor according to the preplan. Postplan was performed after the operation. Data of the D90 (minimum absorbed dose of 90% target volume), V90 (90% prescription dose coverage volume percentage of target volume), V100, V150, and seed number pre- and post-operation were collected and compared. Results: The mean D90, V90, V100, V150, and seed number preoperation were 94.96 ± 16.43 Gy, 94.64% ± 1.43%, 91.21% ± 1.59%, 65.01% ± 5.78%, and 46.67 ± 21.87, respectively. The mean D90, V90, V100, V150, and seed number postoperation were 91.97 ± 17.54 Gy, 93.35% ± 2.45%, 89.35% ± 3.21%, 63.40% ± 6.36%, and 46.60 ± 22.85, respectively. No significant difference between pre- and post-operation was observed across the data (P >0.05). Conclusion: For immobilized malignant tumors, 3D-printed template can be used reproducibly. The dose parameters in preplan can be achieved easily and satisfactorily by 3D-printed template guided brachytherapy, and it may become an easily reproducible standardized procedure in the future.
- Published
- 2019
14. Lung ultrasound vs. chest X-ray in children with suspected pneumonia confirmed by chest computed tomography: A retrospective cohort study.
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Yan, Cui, Hui, Ren, Lijuan, Zhang, and Zhou, Yang
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LUNGS ,PNEUMONIA ,CHEST X rays ,X-rays ,COHORT analysis - Abstract
The chest X-ray is routinely requested by pediatricians for children with suspected pneumonia, but has been demonstrated to be an insensitive method with relatively low accuracy. Computed tomography (CT) allows for the characterization of the consolidation in pneumonia but has a high risk of radiation exposure in children. Lung ultrasonography can identify subpleural lung consolidation in adults, but it is not accepted in routine clinical practice and is also not used for the diagnosis of children with pneumonia. The objective of the present study was to compare diagnostic parameters of lung ultrasound with chest X-ray in children with suspected pneumonia, using CT as a reference standard. Medical records of 949 children, aged ≤16 years, with suspected pneumonia were reviewed. Data regarding the chest radiograph, lung ultrasound and chest CT were collected and analyzed. Beneficial score analysis for each diagnostic modality was evaluated according to the pneumonia severity index. The chest radiograph successfully detected subpleural lung consolidation and dense lung opacity. The lung ultrasound successfully detected pleural effusion and perilesional inflammatory edema. The chest CT successfully detected a liquefied area, enhancement and necrosis of the lungs. Compared with the chest CT, the lung ultrasound displayed 0.906 sensitivity and 0.661 accuracy, while the chest radiograph displayed 0.793 sensitivity and 0.559 accuracy. For a pneumonia severity index of <3, the chest CT displayed a good beneficial score, followed by the lung ultrasound and chest radiograph. In conclusion, lung ultrasound is a non-invasive and simple method that could be used for the diagnosis of suspected pneumonia in children. [ABSTRACT FROM AUTHOR]
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- 2020
- Full Text
- View/download PDF
15. Zone of Transition: A Potential Source of Error in Tumor Volume Estimation
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Anthony P. Reeves, David F. Yankelevitz, Darryl Carter, Lijuan Zhang, Artit C. Jirapatnakul, and Claudia I. Henschke
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Male ,Computed tomography ,Geometry ,Adenocarcinoma ,Volume estimation ,Sensitivity and Specificity ,Imaging, Three-Dimensional ,Full field of view ,Transition zone ,medicine ,Range (statistics) ,Humans ,Radiology, Nuclear Medicine and imaging ,Potential source ,Aged ,Original Research ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,Thoracic Neoplasms ,Single pixel ,Radiographic Image Enhancement ,Volume (thermodynamics) ,Radiographic Image Interpretation, Computer-Assisted ,Female ,Artifacts ,Tomography, X-Ray Computed ,Nuclear medicine ,business - Abstract
To measure the width of the zone of transition (ZOT) between nonaerated solid tumor and surrounding nonneoplastic lung parenchyma and determine the extent to which ZOT influences computer-derived estimates of tumor volume based on computed tomographic (CT) images.This HIPAA-compliant study was approved by the institutional research board. The histologic slide containing the maximum tumor area was digitized for 20 consecutive patients with solid adenocarcinoma. The outer border of the tumor (A2) was marked; it included all lung parenchyma having any tumor cells. The inner border of the tumor (A1) was marked; it included only solid tumor where lung parenchyma was no longer preserved. Assuming two circles with areas of A2 and A1, the corresponding two radii, R2 and R1, were calculated. The average width of the ZOT was defined as R2 minus R1. The relationship between ZOT and tumor diameter on the CT images prior to surgery was assessed by using regression analysis. The relationship between ZOT and tumor volume was assessed by using a theoretical model of idealized spheres with varying diameters.The mean width of the ZOT was 0.78 mm (median, 0.48 mm). The proportional effect of ZOT on tumor volume estimates decreased with increasing tumor diameter and increased with increasing width of ZOT. Correlation between ZOT and tumor diameter was not significant (P = .87).The average width of ZOT is about a single pixel width on a full field of view CT scan; thus, the ZOT can have a large effect on volume estimates, particularly for small tumors.
- Published
- 2010
16. Intraventricular Hemorrhage and Early Hematoma Expansion in Patients with Intracerebral Hemorrhage
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Xinyue Qin, Qi Li, Gang Zhang, Xiao Wei, Mei-Xue Dong, Lijuan Zhang, Fajin Lv, Peng Xie, Yuan-Jun Huang, and Jianjun Chen
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Adult ,Male ,medicine.medical_specialty ,Computed tomography ,Article ,Cerebral Ventricles ,Hematoma ,X ray computed ,medicine ,Odds Ratio ,Humans ,In patient ,cardiovascular diseases ,Aged ,Cerebral Hemorrhage ,Intracerebral hemorrhage ,Aged, 80 and over ,Multidisciplinary ,medicine.diagnostic_test ,business.industry ,Odds ratio ,Middle Aged ,medicine.disease ,Surgery ,nervous system diseases ,Tomography x ray computed ,Intraventricular hemorrhage ,surgical procedures, operative ,Female ,business ,Tomography, X-Ray Computed - Abstract
Intraventricular hemorrhage is associated with poor functional outcomes in patients with intracerebral hemorrhage (ICH). We aimed to investigate the association between intraventricular hemorrhage and early hematoma expansion in patients with ICH. Patients with ICH who underwent a baseline CT scan within six hours after onset of symptoms were included. The follow-up CT scan was performed within 24 hours after the baseline CT scan. Univariate and multivariable logistic regression were used to assess the relationship between presence of intraventricular hemorrhage and early hematoma expansion. A total of 160 patients were included in the study. Significant hematoma growth was observed in 52 (32.5%) patients presenting within six hours after onset of symptoms. Intraventricular hemorrhage was observed in 66 (41.25%) patients with ICH. Multivariate analyses demonstrated that a short time from onset to baseline CT scan, the initial hematoma volume and the presence of intraventricular hemorrhage on follow-up CT scan were independently associated with hematoma enlargement. The presence of intraventricular hemorrhage on follow-up CT scan can be associated with hematoma expansion in patients with ICH.
- Published
- 2015
17. Computed tomography-guided implantation of 125I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results.
- Author
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Jie Li, Lijuan Zhang, Wenhuan Xu, Teng Wang, Leyuan Zhou, Qigen Xie, Weiguo Wang, and Yanyan Hua
- Subjects
- *
INTERSTITIAL brachytherapy , *COMPUTED tomography , *METASTASIS , *CHEMOEMBOLIZATION , *LUNG cancer - Abstract
Purpose: To retrospectively evaluate the efficacy and safety of computed tomography (CT)-guided percutaneous interstitial brachytherapy using 125I radioactive seeds for multiple pulmonary metastatic tumors. Material and methods: Between September 2013 and December 2015, 22 patients with multiple pulmonary metastases, who after conventional chemotherapy and trans-arterial chemoembolization (TACE) therapy were considered unable to withstand stereotactic body radiation therapy (SBRT), received CT-guided 125I brachytherapy. Clinical data were studied retrospectively. A planning target volume of 90% (D90) was 120-160 Gy for 125I seeds with an activity of 25.9 MBq. A CT-based evaluation performed 1, 2, and 6 months' post-implantation enabled review of local control of tumors. Results: Twenty-two patients with 65 pulmonary metastases successfully completed treatment. The mean value for D90 for implantation for 125I seeds was 132 Gy. Complete response (CR) + partial response (PR) was documented in 81.54%, 78.46%, and 78.46% of patients at 1, 2, and 6 months after implantation, respectively. Fourteen out of 22 patients had CR, 3 had PR, 2 had stable disease (SD), and 3 had progressive disease (PD). Most of the metastases (CR + PR + SD; 87.69% after 6 months) were controlled by implantation. Conclusions: CT-guided 125I brachytherapy is a safe and effective treatment for multiple pulmonary metastatic tumors, and can achieve good short-term local control, so long as the radiation dose is sufficient. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
18. Dosimetry study of three-dimensional print template-guided precision 125I seed implantation.
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Zhang Hongtao, Di Xuemin, Yu Huimin, Wang Zeyang, Zhang Lijuan, Zhao Jinxin, Liu Zezhou, Sui Aixia, Wang Juan, Hongtao, Zhang, Xuemin, Di, Huimin, Yu, Zeyang, Wang, Lijuan, Zhang, Jinxin, Zhao, Zezhou, Liu, Aixia, Sui, and Juan, Wang
- Subjects
PROSTATE cancer treatment ,RADIOISOTOPE brachytherapy ,CANCER radiotherapy ,RADIATION dosimetry ,MEDICAL imaging systems ,THREE-dimensional imaging ,COMPUTED tomography ,TUMOR diagnosis ,IODINE radioisotopes ,COMBINED modality therapy ,COMPUTERS in medicine ,RADIATION doses ,RADIATION measurements ,RADIOTHERAPY ,REOPERATION ,TUMORS ,TUMOR classification ,TREATMENT effectiveness ,THERAPEUTICS - Abstract
Objective: This study aimed to compare the dose difference in 125 I seed implantation between three-dimensional (3D) print template-guided operation and traditional implantation.Materials and Methods: This study retrospectively analyzed 27 patients who underwent 125I seed implantation from August 2015 to December 2015 in Hebei General Hospital. Of these, 13 underwent seed implantation guided by a 3D print template, named the template group, and 14 underwent traditional implantation, named the traditional group. All patients underwent computed tomography (CT) scan. Then, 3D templates were printed in the template group. The implantation was guided by CT and 3D templates. The patients in the traditional group underwent implantation with free hands guided by CT scan. Postplan was performed after the operation. The dose-volume histogram, D90, and V90 were calculated. The D90 values pre- and post-operation were compared in each group. The postoperation V90 values of the two groups were also compared.Results: The mean D90 values pre- and post-operation in the template group were (87.09 ± 33.63) Gy and (85.31 ± 34.40) Gy, respectively, with no statistically significant difference. The mean D90 values pre- and post-operation in the traditional group were (86.04 ± 29.93) Gy and (74.96 ± 46.10) Gy, respectively, with a statistically significant difference. The mean V90 values postoperation in the template and traditional groups were (92.76% ± 1.89%) and (84.59% ± 7.56%), respectively, with a statistically significant difference.Conclusions: The postplan and preplan dose parameters of 3D print template-guided seed implantation were nearly consistent. The dose parameters of template group superior to the traditional group. The seeds can be implanted accurately with 3D print template. [ABSTRACT FROM AUTHOR]- Published
- 2016
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19. Combined pulmonary fibrosis and emphysema: a retrospective analysis of clinical characteristics, treatment and prognosis.
- Author
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Lijuan Zhang, Chunling Zhang, Fushi Dong, Qi Song, Fangzhou Chi, Lu Liu, Yupeng Wang, and Chunli Che
- Subjects
PULMONARY fibrosis treatment ,PULMONARY emphysema treatment ,COMPUTED tomography ,SURVIVAL analysis (Biometry) ,DEATH forecasting - Abstract
Background: Combined pulmonary fibrosis and emphysema (CPFE) is increasingly acknowledged as a separate syndrome with distinct clinical, physiological and radiological characteristics. We sought to identify physiologic and radiographic indices that predict mortality in CPFE. Methods: Data on clinical characteristics, pulmonary function, high-resolution computed tomography (HRCT) and treatment were compared between patients with usual interstitial pneumonia (UIP) plus emphysema (CPFE group) and those with IPF alone (IPF group). Composite physiologic index (CPI) and HRCT scores at diagnosis and during follow-up were assessed. Results: CPFE group (N = 87) was characterized by the predominance of males and smokers, who were less likely to have viral infection prior to the diagnosis, and display basal crackles, finger clubbing and wheeze, as compared to that in the IPF group (N = 105). HRCT and CPI scores increased over time in both groups. Moreover, CPFE group had a poorer prognosis, lower 5-year survival rate (43.42 % vs. 65.56 %; P < 0.05), and higher mortality (39.47 % vs. 23.33 %; P < 0.05) as compared to that in the IPF group. All CPFE patients received oxygen therapy, antibiotics and oral N-acetylcysteine; > 50 % received bronchodilators, 40 % received corticosteroids and 14 % needed noninvasive mechanical ventilation. On survival analyses, pulmonary arterial hypertension (PAH) and ≥ 5-point increase in CPI score per year were predictors of mortality in the CPFE group (hazard ratio [HR]: 10.29, 95 % Confidence Interval [CI]: 2.69-39.42 and HR: 21.60, 95 % CI: 7.28-64.16, respectively). Conclusion: Patients with CPFE were predominantly male and smokers and exhibited distinct clinical, physiological and radiographic characteristics. They had a poorer prognosis than IPF. PAH and ≥ 5-point increase in CPI score per year were predictors of mortality in these patients. Future studies are needed to identify the optimal treatment approach to CPFE. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
20. Combined pulmonary fibrosis and emphysema: a retrospective analysis of clinical characteristics, treatment and prognosis
- Author
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Lu Liu, Lijuan Zhang, Chunli Che, Fangzhou Chi, Yupeng Wang, Chunling Zhang, Qi Song, and Fushi Dong
- Subjects
Male ,Pulmonary and Respiratory Medicine ,China ,medicine.medical_specialty ,Pathology ,Vital Capacity ,Idiopathic pulmonary fibrosis ,Severity of Illness Index ,Gastroenterology ,Pulmonary function testing ,03 medical and health sciences ,Combined pulmonary fibrosis and emphysema ,0302 clinical medicine ,Usual interstitial pneumonia ,The composite physiologic index ,Forced Expiratory Volume ,Internal medicine ,Severity of illness ,Humans ,Medicine ,030212 general & internal medicine ,Computed tomography ,Lung ,Survival rate ,Aged ,Retrospective Studies ,business.industry ,Hazard ratio ,Oxygen Inhalation Therapy ,Middle Aged ,respiratory system ,Prognosis ,medicine.disease ,Survival Analysis ,Acetylcysteine ,Anti-Bacterial Agents ,respiratory tract diseases ,Pulmonary Emphysema ,030228 respiratory system ,Female ,Crackles ,medicine.symptom ,Tomography, X-Ray Computed ,business ,Research Article - Abstract
Background Combined pulmonary fibrosis and emphysema (CPFE) is increasingly acknowledged as a separate syndrome with distinct clinical, physiological and radiological characteristics. We sought to identify physiologic and radiographic indices that predict mortality in CPFE. Methods Data on clinical characteristics, pulmonary function, high-resolution computed tomography (HRCT) and treatment were compared between patients with usual interstitial pneumonia (UIP) plus emphysema (CPFE group) and those with IPF alone (IPF group). Composite physiologic index (CPI) and HRCT scores at diagnosis and during follow-up were assessed. Results CPFE group (N = 87) was characterized by the predominance of males and smokers, who were less likely to have viral infection prior to the diagnosis, and display basal crackles, finger clubbing and wheeze, as compared to that in the IPF group (N = 105). HRCT and CPI scores increased over time in both groups. Moreover, CPFE group had a poorer prognosis, lower 5-year survival rate (43.42 % vs. 65.56 %; P 50 % received bronchodilators, 40 % received corticosteroids and 14 % needed noninvasive mechanical ventilation. On survival analyses, pulmonary arterial hypertension (PAH) and ≥ 5-point increase in CPI score per year were predictors of mortality in the CPFE group (hazard ratio [HR]: 10.29, 95 % Confidence Interval [CI]: 2.69–39.42 and HR: 21.60, 95 % CI: 7.28–64.16, respectively). Conclusion Patients with CPFE were predominantly male and smokers and exhibited distinct clinical, physiological and radiographic characteristics. They had a poorer prognosis than IPF. PAH and ≥ 5-point increase in CPI score per year were predictors of mortality in these patients. Future studies are needed to identify the optimal treatment approach to CPFE.
- Full Text
- View/download PDF
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