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Policies are authoritative assets that are present in multiple domains to support decision-making. They describe what actions are allowed or recommended when domain entities and their attributes satisfy certain criteria. It is common to find policies that contain geographical rules, including distance and containment relationships among named locations. These locations' polygons can often be found encoded in geospatial datasets. We present an approach to transform data from geospatial datasets into Linked Data using the OWL, PROV-O, and GeoSPARQL standards, and to leverage this representation to support automated ontology-based policy decisions. We applied our approach to location-sensitive radio spectrum policies to identify relationships between radio transmitters coordinates and policy-regulated regions in Census.gov datasets. Using a policy evaluation pipeline that mixes OWL reasoning and GeoSPARQL, our approach implements the relevant geospatial relationships, according to a set of requirements elicited by radio spectrum domain experts., Comment: 4th International Workshop on Geospatial Linked Data (GeoLD 2021) at ESWC 2021

With the rapid advancements in cancer research, the information that is useful for characterizing disease, staging tumors, and creating treatment and survivorship plans has been changing at a pace that creates challenges when physicians try to remain current. One example involves increasing usage of biomarkers when characterizing the pathologic prognostic stage of a breast tumor. We present our semantic technology approach to support cancer characterization and demonstrate it in our end-to-end prototype system that collects the newest breast cancer staging criteria from authoritative oncology manuals to construct an ontology for breast cancer. Using a tool we developed that utilizes this ontology, physician-facing applications can be used to quickly stage a new patient to support identifying risks, treatment options, and monitoring plans based on authoritative and best practice guidelines. Physicians can also re-stage existing patients or patient populations, allowing them to find patients whose stage has changed in a given patient cohort. As new guidelines emerge, using our proposed mechanism, which is grounded by semantic technologies for ingesting new data from staging manuals, we have created an enriched cancer staging ontology that integrates relevant data from several sources with very little human intervention., Comment: International Semantic Web Conference (Resource Track)

Our work concerns the elucidation of the cancer (epi)genome, transcriptome and proteome to better understand the complex interplay between a cancer cell's molecular state and its response to anti-cancer therapy. To study the problem, we have previously focused on data warehousing technologies and statistical data integration. In this paper, we present recent work on extending our analytical capabilities using Semantic Web technology. A key new component presented here is a SPARQL endpoint to our existing data warehouse. This endpoint allows the merging of observed quantitative data with existing data from semantic knowledge sources such as Gene Ontology (GO). We show how such variegated quantitative and functional data can be integrated and accessed in a universal manner using Semantic Web tools. We also demonstrate how Description Logic (DL) reasoning can be used to infer previously unstated conclusions from existing knowledge bases. As proof of concept, we illustrate the ability of our setup to answer complex queries on resistance of cancer cells to Decitabine, a demethylating agent., Comment: in Adrian Paschke, Albert Burger, Andrea Splendiani, M. Scott Marshall, Paolo Romano: Proceedings of the 3rd International Workshop on Semantic Web Applications and Tools for the Life Sciences, Berlin,Germany, December 8-10, 2010