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Contemporary research advances in nanotechnology and material science are rooted in the emergence of nanodevices as a versatile tool that harmonizes sensing, computing, wireless communication, data storage, and energy harvesting. These devices offer novel pathways for disease diagnostics, treatment, and monitoring within the bloodstreams. Ensuring precise localization of events of diagnostic interest, which underpins the concept of flow-guided in-body nanoscale localization, would provide an added diagnostic value to the detected events. Raw data generated by the nanodevices is pivotal for this localization and consist of an event detection indicator and the time elapsed since the last passage of a nanodevice through the heart. The energy constraints of the nanodevices lead to intermittent operation and unreliable communication, intrinsically affecting this data. This posits a need for comprehensively modelling the features of this data. These imperfections also have profound implications for the viability of existing flow-guided localization approaches, which are ill-prepared to address the intricacies of the environment. Our first contribution lies in an analytical model of raw data for flow-guided localization, dissecting how communication and energy capabilities influence the nanodevices' data output. This model acts as a vital bridge, reconciling idealized assumptions with practical challenges of flow-guided localization. Toward addressing these practical challenges, we also present an integration of Graph Neural Networks (GNNs) into the flow-guided localization paradigm. GNNs excel in capturing complex dynamic interactions inherent to the localization of events sensed by the nanodevices. Our results highlight the potential of GNNs not only to enhance localization accuracy but also extend coverage to encompass the entire bloodstream., Comment: 16 pages, 16 figures, 6 tables, 45 references

Nanoscale devices with Terahertz (THz) communication capabilities are envisioned to be deployed within human bloodstreams. Such devices will enable fine-grained sensing-based applications for detecting early indications (i.e., biomarkers) of various health conditions, as well as actuation-based ones such as targeted drug delivery. Associating the locations of such events with the events themselves would provide an additional utility for precision diagnostics and treatment. This vision yielded a new class of in-body localization coined under the term "flow-guided nanoscale localization". Such localization can be piggybacked on THz communication for detecting body regions in which biological events were observed based on the duration of one circulation of a nanodevice in the bloodstream. From a decades-long research on objective benchmarking of "traditional" indoor localization, as well as its eventual standardization (e.g., ISO/IEC 18305:2016), we know that in early stages the reported performance results were often incomplete (e.g., targeting a subset of relevant performance metrics), carrying out benchmarking experiments in different evaluation environments and scenarios, and utilizing inconsistent performance indicators. To avoid such a "lock-in" in flow-guided localization, in this paper we propose a workflow for standardized performance evaluation of such localization. The workflow is implemented in the form of an open-source simulation framework that is able to jointly account for the mobility of the nanodevices, in-body THz communication between with on-body anchors, and energy-related and other technological constraints (e.g., pulse-based modulation) at the nanodevice level. Accounting for these constraints, the framework is able to generate the raw data that can be streamlined into different flow-guided localization solutions for generating standardized performance benchmarks., Comment: 10 pages, 9 figures, 34 references, code available at: https://bitbucket.org/filip_lemic/flow-guided-localization-in-ns3/src/sequential/