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In-memory processing can dramatically improve the latency and energy consumption of computing systems by minimizing the data transfer between the memory and the processor. Efficient execution of processing operations within the memory is therefore, a highly motivated objective in modern computer architecture. This article presents a novel automatic framework for efficient implementation of arbitrary combinational logic functions within a memristive memory. Using tools from logic design, graph theory and compiler register allocation technology, we developed synthesis and in-memory mapping of logic execution in a single row (SIMPLER), a tool that optimizes the execution of in-memory logic operations in terms of throughput and area. Given a logical function, SIMPLER automatically generates a sequence of atomic memristor-aided logic (MAGIC) NOR operations and efficiently locates them within a single size-limited memory row, reusing cells to save area when needed. This approach fully exploits the parallelism offered by the MAGIC NOR gates. It allows multiple instances of the logic function to be performed concurrently, each compressed into a single row of the memory. This virtue makes SIMPLER an attractive candidate for designing in-memory single instruction, multiple data (SIMD) operations. Compared to the previous work (that optimizes latency rather than throughput for a single function), SIMPLER achieves an average throughput improvement of 435 ×. When the previous tools are parallelized similarly to SIMPLER, SIMPLER achieves higher throughput of at least 5 ×, with 23 × improvement in area and 20 × improvement in area efficiency. These improvements more than fully compensate for the increase (up to 17% on average) in latency. [ABSTRACT FROM AUTHOR]