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As shown in computer vision, the power of deep learning lies in automatically learning relevant and powerful features for any perdition task, which is made possible through end-to-end architectures. However, deep learning approaches applied for classifying medical images do not adhere to this architecture as they rely on several pre- and post-processing steps. This shortcoming can be explained by the relatively small number of available labeled subjects, the high dimensionality of neuroimaging data, and difficulties in interpreting the results of deep learning methods. In this paper, we propose a simple 3D Convolutional Neural Networks and exploit its model parameters to tailor the end-to-end architecture for the diagnosis of Alzheimer's disease (AD). Our model can diagnose AD with an accuracy of 94.1\% on the popular ADNI dataset using only MRI data, which outperforms the previous state-of-the-art. Based on the learned model, we identify the disease biomarkers, the results of which were in accordance with the literature. We further transfer the learned model to diagnose mild cognitive impairment (MCI), the prodromal stage of AD, which yield better results compared to other methods.

Being able to predict clinical parameters in order to diagnose gait disorders in a patient is of great value in planning treatments. It is known that \textit{decision parameters} such as cadence, step length, and walking speed are critical in the diagnosis of gait disorders in patients. This project aims to predict the decision parameters using two ways and afterwards giving advice on whether a patient needs treatment or not. In one way, we use clinically measured parameters such as Ankle Dorsiflexion, age, walking speed, step length, stride length, weight over height squared (BMI) and etc. to predict the decision parameters. In a second way, we use videos recorded from patient's walking tests in a clinic in order to extract the coordinates of the joints of the patient over time and predict the decision parameters. Finally, having the decision parameters we pre-classify gait disorder intensity of a patient and as the result make decisions on whether a patient needs treatment or not., Comment: 6 pages

In this work, we use a deep learning framework for simultaneous classification and regression of Parkinson disease diagnosis based on MR-Images and personal information (i.e. age, gender). We intend to facilitate and increase the confidence in Parkinson disease diagnosis through our deep learning framework.