1. Genetic analysis of a divergent selection for resistance to Rous sarcomas in chickens
- Author
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Pinar-van der Laan, M.H., Soubieux, Denis, Mérat, L., Bouret, D., Luneau, Gaelle, Dambrine, Ginette, Thoraval, P., Génétique et Diversité Animales (GEDANIM), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Bio-Agresseurs, Santé, Environnement [Nouzilly] (UR BASE), Institut National de la Recherche Agronomique (INRA), and Unité de pathologie animale
- Subjects
[SDV.GEN]Life Sciences [q-bio]/Genetics ,RESISTANCE ,RFP-Y ,chicken ,poulet ,gallus gallus ,selection ,paramètre génétique ,resistance ,[SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics ,sarcome de rous ,Rous sarcoma ,sélection ,ComputingMilieux_MISCELLANEOUS ,Rfp-Y - Abstract
International audience; Selection for disease resistance related traits is a tool of choice for evidencing and exploring genetic variability and studying underlying resistance mechanisms. In this framework, chickens originating from a base population, homozygote for the $B^{19}$ major histocompatibility complex (MHC) were divergently selected for either progression or regression of tumors induced at 4 weeks of age by a SR-D strain of Rous sarcoma virus (RSV). The first generation of selection was based on a progeny test and subsequent selections were performed on full-sibs. Data of 18 generations including a total of 2010 birds measured were analyzed for the tumor profile index (TPI), a synthetic criterion of resistance derived from recording the volume of the tumors and mortality. Response to selection and heritability of TPI were estimated using a restricted maximum likelihood method with an animal model. Significant progress was shown in both directions: the lines differing significantly for TPI and mortality becoming null in the "regressor" line. Heritability of TPI was estimated as 0.49 $\pm $ 0.05 and 0.53 $\pm $ 0.06 within the progressor and regressor lines respectively, and 0.46 $\pm $ 0.03 when estimated over lines. Preliminary results showed within the progressor line a possible association between one Rfp-Y type and the growth of tumors.
- Published
- 2004
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