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2 results on '"Baysal, Erkan"'

1. The effects of hyperoxaemia on tissue oxygenation in patients with a nadir haematocrit lower than 20% during cardiopulmonary bypass.

Author

Sevuk, Utkan, Altindag, Rojhat, Baysal, Erkan, Yaylak, Baris, Adiyaman, Mehmet Sahin, Akkaya, Suleyman, Ay, Nurettin, and Alp, Vahhac

Subjects
*ACTIVE oxygen in the body, *ANEMIA, *BLOOD gases analysis, *CARDIOPULMONARY bypass, *CHI-squared test, *CONFIDENCE intervals, *HEMATOCRIT, *LACTATES, *MULTIVARIATE analysis, *PERFUSION, *STATISTICS, *T-test (Statistics), *LOGISTIC regression analysis, *HYPEROXIA, *RETROSPECTIVE studies, *DATA analysis software, *ODDS ratio, *MANN Whitney U Test
Abstract

Excessive haemodilution and the resulting anaemia during CPB is accompanied by a decrease in the total arterial oxygen content, which may impair tissue oxygen delivery. Hyperoxic ventilation has been proven to improve tissue oxygenation in different pathophysiological states of anaemic tissue hypoxia. The aim of this study was to examine the influence of arterial hyperoxaemia on tissue oxygenation during CPB. Records of patients undergoing isolated CABG with CPB were retrospectively reviewed. Patients with nadir haematocrit levels below 20% during CPB were included in the study. Tissue hypoxia was defined as hyperlactataemia (lactate >2.2 mmol/L) coupled with low ScVO2 (ScVO2 <70%) during CPB. One hundred patients with normoxaemia and 100 patients with hyperoxaemia were included in the study. Patients with hyperoxaemia had lower tissue hypoxia incidence than patients with normoxaemia (p<0.001). Compared with patients without tissue hypoxia, patients with tissue hypoxia had significantly lower PaO2 values (p<0.001) and nadir haematocrit levels (p<0.001). Nadir haematocrit levels <18% (OR: 5.3; 95% CI: 2.67–10.6; p<0.001) and hyperoxaemia (OR: 0.28; 95% CI: 0.14–0.56; p<0.001) were independently associated with tissue hypoxia. Conclusions: Hyperoxaemia during CPB may be protective against tissue hypoxia in patients with nadir haematocrit levels <20%. [ABSTRACT FROM AUTHOR]

Published
2016
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2. Increased Platelet Distribution Width Is Associated With ST-Segment Elevation Myocardial Infarction and Thrombolysis Failure.

Author

Cetin, Mustafa, Bakirci, Eftal Murat, Baysal, Erkan, Tasolar, Hakan, Balli, Mehmet, Cakici, Musa, Abus, Sabri, Akturk, Erdal, and Ozgul, Sami

Subjects
*MYOCARDIAL infarction treatment, *ANALYSIS of variance, *CHI-squared test, *CONFIDENCE intervals, *FISHER exact test, *T-test (Statistics), *THROMBOLYTIC therapy, *TREATMENT effectiveness, *RETROSPECTIVE studies, *RECEIVER operating characteristic curves, *DATA analysis software, *DESCRIPTIVE statistics, *ODDS ratio
Abstract

We investigated 2 hypotheses: (1) a relationship between platelet indices and stable coronary artery disease (CAD) and acute ST-segment elevation myocardial infarction (STEMI) and (2) a relationship between platelet indices on admission and thrombolysis outcomes in patients with STEMI. A total of 260 patients were enrolled. The white blood cell (WBC) and platelet distribution width (PDW) were found to be increased in patients with STEMI (P for both < .001). White blood cell and PDW were independent predictors of acute STEMI. Mean platelet volume (MPV) and PDW were significantly higher in the thrombolysis failure group than in the thrombolysis success group (9.9 ± 1.8 vs 9.2 ± 1.5 fL, P = .021 and 17.7 ± 1.0 vs 16.4 ± 2.1 fL, P < .001, respectively). Mean platelet volume and PDW were independent predictors of thrombolysis failure. Patients with acute STEMI had higher PDW than did patients with stable CAD. In addition, higher PDW and MPV seem to correlate with thrombolysis failure in patients with STEMI. [ABSTRACT FROM AUTHOR]

Published
2014
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