1. Long-term complications of toxic epidermal necrolysis (Lyell's disease). Clinical and histopathologic study.
- Author
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de Felice GP, Caroli R, and Autelitano A
- Subjects
- Adult, Conjunctiva pathology, Conjunctival Diseases pathology, Cornea pathology, Corneal Diseases etiology, Corneal Diseases pathology, Humans, Male, Stevens-Johnson Syndrome pathology, Conjunctival Diseases etiology, Stevens-Johnson Syndrome complications
- Abstract
A case of toxic epidermal necrolysis had been observed in a 4-year-old child. This patient has been reexamined by us 21 years later. At that time a biopsy of conjunctival material and a histopathologic and ultrastructural study were done. The long-term ocular complications of the disease caused severe visual impairment with a remarkable sicca syndrome due to extensive scarring and keratinization, as confirmed also by light- and electron-microscopic features. These findings, concerning a particularly long follow-up, suggest that the ocular sequelae of this disease require continuous ophthalmological supervision many years after the acute stage of the disease.
- Published
- 1987
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