1. Microneedling with topical vitamin C versus microneedling with topical insulin in the treatment of atrophic post-acne scars: A split-face study.
- Author
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Abbas MAM, Elgamal EEAE, Zaky MS, and Elsaie ML
- Subjects
- Ascorbic Acid, Atrophy therapy, Cicatrix diagnosis, Cicatrix etiology, Cicatrix therapy, Humans, Insulin, Needles, Treatment Outcome, Acne Vulgaris complications, Acne Vulgaris therapy, Connective Tissue Diseases, Cosmetic Techniques adverse effects
- Abstract
Post acne scars following sebaceous injury and abnormal wound healing during the course of acne is a prevalent and challenging to treat condition To evaluate microneedling by dermapen with topical vitamin C versus microneedling with topical insulin in treating atrophic post-acne scars. A split-face comparative study included 30 subjects with atrophic post-acne scars. Human insulin was topically applied to the left side of the face and on the right side, vitamin C serum was applied. Scars were assessed via the Acne Scar Assessment Scale (ASAS) and Scar quartile grading scale (SQGS). After 1 month of 4 treatments, a statistically significant mean improvement in ASAS value was reported on both split sides of the face (2.13 and 1.83) compared to baseline (3.03 and 2.93) (p = 0.005; p = 0.001 respectively). When compared to baseline, the mean ASAS value improved significantly with a slight more improvement on the vitamin c treated side. Topical insulin and vitamin c combined with microneedling, may both achieve comparable significant improvement for treating post acne scars. Insulin can be a promising novel anti-scarring therapy pending larger controlled studies to verify its efficacy., (© 2022 Wiley Periodicals LLC.)
- Published
- 2022
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