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Start Over Author "Birnoschi L" Topic continuous processing
2 results on '"Birnoschi L"'

1. A Convergent Continuous Multistep Process for the Preparation of C4-Oxime-Substituted Thiazoles

Author

Godineau, E, Battilocchio, C, Lehmann, M, Ley, SV, Labes, R, Birnoschi, L, Subramanian, S, Prasanna, CS, Gorde, A, Kalbagh, M, Khade, V, Scherrer, A, and O'sullivan, ACC

Subjects
Bromination, hazardous chemistry, thiazole synthesis, continuous processing
Abstract

We report a strategy designed for the rapid and convergent assembly of C4-oxime substituted thiazoles. Our approach relied on 3-bromo-2-oxopropanal O-methyl oxime 7 as a key building block. A three-step sequence to 7 was designed, which for safety concerns, could only be operated in batch mode on limited scales (<< 100g). We describe herein how we addressed such a limitation, by designing a multistep continuous synthesis of this intermediate and further demonstrate the advantages of flow reactor configuration upon scaling up., Syngenta

Published
2018
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2. A Convergent Continuous Multistep Process for the Preparation of C4-Oxime-Substituted Thiazoles

Author

Godineau, E, Battilocchio, C, Lehmann, M, Ley, SV, Labes, R, Birnoschi, L, Subramanian, S, Prasanna, CS, Gorde, A, Kalbagh, M, Khade, V, Scherrer, A, O'sullivan, ACC, Ley, Steven [0000-0002-7816-0042], Labes, Ricardo [0000-0003-4001-0775], and Apollo - University of Cambridge Repository

Subjects
Bromination, hazardous chemistry, thiazole synthesis, continuous processing
Abstract

We report a strategy designed for the rapid and convergent assembly of C4-oxime substituted thiazoles. Our approach relied on 3-bromo-2-oxopropanal O-methyl oxime 7 as a key building block. A three-step sequence to 7 was designed, which for safety concerns, could only be operated in batch mode on limited scales (<< 100g). We describe herein how we addressed such a limitation, by designing a multistep continuous synthesis of this intermediate and further demonstrate the advantages of flow reactor configuration upon scaling up.

Published
2018

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