1. Deep learning based classification of solid lipid-poor contrast enhancing renal masses using contrast enhanced CT.
- Author
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Oberai A, Varghese B, Cen S, Angelini T, Hwang D, Gill I, Aron M, Lau C, and Duddalwar V
- Subjects
- Adenoma, Oxyphilic diagnostic imaging, Angiomyolipoma diagnostic imaging, Carcinoma, Renal Cell diagnostic imaging, Female, Humans, Kidney Neoplasms diagnostic imaging, Male, Middle Aged, Retrospective Studies, Tomography, X-Ray Computed methods, Adenoma, Oxyphilic classification, Angiomyolipoma classification, Carcinoma, Renal Cell classification, Contrast Media, Deep Learning, Kidney Neoplasms classification
- Abstract
Objective: Establish a workflow that utilizes convolutional neural nets (CNN) to classify solid, lipid-poor, contrast enhancing renal masses using multiphase contrast enhanced CT (CECT) images and to assess the performance of the resulting network., Methods: In this institutional review board approved study of 143 patients with predominantly solid, lipid-poor, contrast enhancing renal lesions (46 benign and 97 malignant), patients with a pre-operative multiphase CECT of the abdomen and pelvis obtained between June 2009 and June 2015 were retrospectively queried. Benign renal masses included oncocytoma and lipid-poor angiomyolipoma and the malignant group included clear cell, papillary, and chromophobe carcinomas.Region of interests of whole tumor volumes were manually segmented, and CT phase images with the largest cross-section of the segmented tumor in the axial plane were used for assessment. Post-surgical pathological evaluation was used to establish diagnosis.The segmented images of renal masses were used as input to a CNN. The data were augmented and split into training (83.9%) and validation sets (16.1%) to determine the hyperparameters of the CNN. Thereafter. the performance of the resulting CNN was quantified using eightfold cross-validation., Results: The CNN-based classifier demonstrated an overall accuracy of 78% (95% confidence interval: 76-80%), sensitivity of 70% (95% confidence interval: 66-74%), specificity of 81% (79-83%) and an area under the curve of 0.82., Conclusion: A CNN-based classifier to diagnose solid enhancing malignant renal masses based on multiphase CECT images was developed., Advances in Knowledge: It was established that a CNN-based classifier could be trained to accurately distinguish malignant renal lesions.
- Published
- 2020
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