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Heart failure is a state where the cardiac function is sufficiently compromised resulting in clinical signs inspite of the compensatory mechanism. Based on various diagnostic procedures, a total of 342 dogs of various breed, sex and age were diagnosed for cardiac failure of various etiology. Hematologically, no significant difference was noticed but, biochemically, there was a significant increase (P<0.01) in mean values of CKMB (56.95 ± 2.94u/L), LDH (141.40 ± 5.14 u/L) but with a significantly low (P<0.05) levels of TP (5.36 ± 0.15 g/dL) and Alb (2.85 ± 0.9 g/ dL). Similarly, a non-significant hypernatremia (141.08 ± 0.57 mEq/dL) and significant hypokalemia (3.86 ± 0.14 mEq/dL) was also noticed in comparison with apparently healthy dogs. Abnormal P, QRS and T wave along with ventricular premature complexes were the significant ECG findings and cardiomegaly, auricular bulge with elevated trachea and pulmonary venous congestion were the significant radiographic abnormalities recorded. On 2-D echocardiography, dilated cardiomyopathy was the primary cardiac disorder recorded in 69% cases, followed by valvular disease (mitral valve insufficiency in 38%, tricuspid valve insufficiency in 14%), pericardial effusion in 22% and relatively rare hypertrophic cardiomyopathy in 4 dogs. Following therapy with ACE inhibitors, diuretics, beta blockers, positive ionotropes and neutraceutical for 6 months, significant signs viz., dyspnoea at rest, cough and exercise intolerance disappeared after 20-25 days in 90% dogs, followed by improvement in appetite, weight and systemic circulation in 30-35 days. Whereas, no significant difference was noticed with ECG and radiographic findings. However, a significant improvement in left ventricle dimensions, EF and Fs was noticed by the end of treatment. Despite of every effort, 26 dogs of severe heart failure (DCM-13; MVI-8 and pericardial effusion-5) developed azotemia and collapsed during 10-40 days of therapy. [ABSTRACT FROM AUTHOR]

The present investigation was undertaken to evaluate the comparative therapeutic efficacy of Ceftriaxone-Tazobactum and Amoxicillin-Dicloxacillin for management of caprine clinical mastitis. Mastitic quarters of goats were diagnosed to be associated with Staphylococcus spp., Streptococcus spp., E.coliand Klebsiella infection. The organisms showed highest sensititvity to Ceftriaxone followed by Amoxy-Clav, Enrofloxacin, Gentamicin, whereas, all isolates were resistant to Penicillin G. The clinical and bacteriological cure rates obtained in the present study were found to be 100 percent in both groups. The response was excellent in animals treated with Ceftriaxone-Tazobactum @ 10 mg/kg b.wt as there was marked relief of symptoms by second day of treatment itself. Goats treated with Amoxicillin-Dicloxacillin @ 10 mg/kg b.wt responded slowly. Mild relief was noticed on second day but marked effect was evident third day onwards. Both groups were given supportive treatment with Flunixin meglumine. Isolation studies were conducted again on 5th day after recovery in both groups and all samples were found to be culturally negative. [ABSTRACT FROM AUTHOR]