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Laminar free convection heat transfer in power-law fluids from two side-by-side cylinders (one hot and one cold) confined in a square duct has been studied numerically in the two-dimensional flow regime. For a fixed value of the ratio of cylinder radius to size of the enclosure, the effect of geometrical placement of the cylinders is studied on the resulting velocity and temperature fields in the laminar free convection regime by considering six asymmetric locations of the two cylinders. In particular, extensive results reported herein span the range of conditions of Grashof number, 10 to 105; Prandtl number, 0.7 to 100, thereby yielding the range of the Rayleigh number as 7 to 107; power-law index, 0.3 to 1.8; and the relative positions (dimensionless) of the cylinders with respect to the centerline, –0.25 to 0.25. The heat transfer characteristics are analyzed in terms of the local Nusselt number along the surfaces of the two cylinders and the enclosure walls. Overall, the average Nusselt number shows a positive dependence on both the Grashof number and the Prandtl number irrespective of the values of power-law index and relative positioning of the cylinders. Also, all else being equal, shear-thinning fluid behavior promotes heat transfer with reference to that in Newtonian fluids. When the two cylinders are situated close to the bottom wall, the rate of heat transfer is augmented with reference to that for the symmetric positioning of the cylinders along the horizontal mid-plane of the enclosure. Conversely, heat transfer deteriorates as the cylinders are located above the centerline of the enclosure. The present numerical results have been consolidated via the use of a modified Rayleigh number, thereby enabling the estimation of the average Nusselt number in a new application. [ABSTRACT FROM PUBLISHER]