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A new copper‐catalyzed sp3‐carbon radical/halogen radical cross‐coupling strategy for the formation of C(sp3)‐X bond is described. This provides a general method for synthesis of α‐halogenated and α,α‐dihalogenated‐1,3‐dicarbonyl compounds using sodium halides as halogen source under mild conditions. [ABSTRACT FROM AUTHOR]

Copper-catalyzed radical methylation of 1,3-diketones with tert -butyl peroxybenzoate in air is described, providing a general pathway to α -methyl 1,3-diketones in moderate to good yields. This protocol has been scaled up to 50 g, and one of the synthesized products can be used in the synthesis of medicine, Rosuvastatin. [ABSTRACT FROM AUTHOR]

The N-arylation of amines with arylhydrazines has been developed, achieving the selective cross-coupling of aryl radicals with amines to form N -aryl amines. The reaction uses air as an oxidant, CoPc and Cu(OAc) 2 as catalysts. The reaction proceeds under mild conditions in air through a relay process, arylhydrazines are oxidized to aryldiazenes by CoPc, further oxidized to aryl radicals by air (O 2 ), which are trapped by Cu(OAc) 2 –amine complex, followed by reduction–elimination reaction to form N -aryl amines. Arylamines and arylhydrazines give the highest yields, but N -aryl- N -alkylamines and N -alkylamines can be used as well. [ABSTRACT FROM AUTHOR]