1. Pre-operative systemic inflammatory response index influences long-term survival rate in off-pump surgical revascularization.
- Author
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Urbanowicz, Tomasz, Olasińska-Wiśniewska, Anna, Michalak, Michał, Perek, Bartłomiej, Al-Imam, Ahmed, Rodzki, Michał, Witkowska, Anna, Straburzyńska-Migaj, Ewa, Bociański, Michał, Misterski, Marcin, Lesiak, Maciej, and Jemielity, Marek
- Subjects
REVASCULARIZATION (Surgery) ,SURVIVAL rate ,CORONARY artery bypass ,INFLAMMATION ,CORONARY arteries ,CORONARY artery disease ,STRESS echocardiography - Abstract
Coronary artery bypass revascularization is still the optimal treatment for complex coronary artery disease with good long-term results. The relation between inflammatory activation in the post-operative period and the long-term prognosis was already postulated. The possible predictive role of preoperative inflammatory indexes after the off-pump coronary artery bypass grafting technique on long term survival was the aim of the study. Study population included 171 patients with a median age of 64 years (59–64) operated on using off-pump technique between January and December 2014. Patients enrolled in the current study were followed-up for 8 years. We conducted a multivariable analysis of pre-operative and post-operative inflammatory markers based on analysis of the whole blood count. The overall survival rate was 80% for the total follow-up period, while 34 deaths were reported (30-days mortality rate of 1%). In the multivariable analysis, a pre-operative value of systemic inflammatory response index (SIRI) >1.27 (HR = 6.16, 95% CI 2.17–17.48, p = 0.012) revealed a prognostic value for long-term mortality assessment after off-pump surgery. Preoperative inflammatory activation evaluated by systemic inflammatory reaction index (SIRI) possess a prognostic value for patients with complex coronary artery disease. The SIRI value above 1.27 indicates a worse late prognosis after off-pump coronary artery bypass (AUC = 0.682, p<0.001). [ABSTRACT FROM AUTHOR]
- Published
- 2022
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