1. Coronary artery calcification in Takayasu's arteritis: clinical characteristics and risk factors.
- Author
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Yang S, Zhang N, Zhao W, Du J, Gao N, Shi X, Zhang Y, Liu J, and Pan L
- Subjects
- Humans, Female, Male, Retrospective Studies, Adult, Middle Aged, Risk Factors, Prevalence, Severity of Illness Index, Glucocorticoids therapeutic use, Glucocorticoids adverse effects, Young Adult, Heart Disease Risk Factors, Takayasu Arteritis diagnostic imaging, Takayasu Arteritis epidemiology, Takayasu Arteritis drug therapy, Takayasu Arteritis complications, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease epidemiology, Coronary Artery Disease etiology, Vascular Calcification diagnostic imaging, Vascular Calcification epidemiology, Computed Tomography Angiography, Coronary Angiography
- Abstract
Objectives: Coronary artery calcification (CAC) is frequently observed in Takayasu's arteritis (TAK). Our objective is to calculate the prevalence and severity of CAC in TAK, while evaluating the influence of traditional cardiovascular risk factors, glucocorticoid exposure, and disease activity on CAC., Methods: This retrospective study involved 155 TAK patients. We measured the Agatston score by coronary computed tomography angiography (CCTA) and categorised all patients into groups with or without CAC (41 vs. 114) to compare clinical characteristics and ancillary findings between the two groups., Results: Among the TAK patients, a total of 41 TAK patients (26.45%) exhibited CAC. Age of onset, disease duration, history of hypertension, history of hyperlipidaemia, Numano V and glucocorticoid use emerged as the independent risk factors for developing CAC in TAK (OR [95% CI] 1.084[1.028-1.142], p=0.003; 1.005 [1.001-1.010], p=0.020; 4.792 [1.713-13.411], p=0.003; 4.199 [1.087-16.219], p=0.037; 3.287 [1.070-10.100], p=0.038; 3.558[1.269-9.977], p=0.016). Nonetheless, CAC was not associated with disease activity. Moreover, the extent of calcification score in TAK showed a positive correlation with the number of traditional cardiovascular risk factors., Conclusions: We recommend CCTA screening for Numano V classified TAK patients. Glucocorticoid usage significantly escalates the risk of CAC. Therefore, in cases of effectively controlled disease, the inclusion of immunosuppressants aimed at reducing glucocorticoid dosage is advisable.
- Published
- 2024
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