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Background: The association of dietary patterns and metabolic syndrome with the severity of coronary artery disease (CAD) is little known., Aim: This study aimed to explore the relationship between major dietary patterns and the severity of CAD among newly discovered patients by using structural equation modeling (SEM)., Methods: In this cross-sectional study, we included 423 newly diagnosed patients with CAD, aged 35-65 years, who underwent coronary angiography. The severity of CAD was assessed by the Gensini score. All patients were tested by using a semi-quantitative food frequency questionnaire, international physical activity questionnaire, perceived stress scale, lipid profile, fasting blood glucose, and anthropometric and blood pressure measurements. Statistical analysis was performed using SPSS and AMOS version 24., Results: Two dietary patterns (DPs) were identified by principal components analysis and labeled as "unhealthy DP" and "healthy DP". The results of SEM analysis showed that the unhealthy DP has a significant positive direct association with the severity of CAD (β=0.304, p <0.001), which is indirectly mediated by the presence of metabolic syndrome (β=0.021, p =0.021), adjusted for age and perceived stress scale. However, healthy DP has a significant negative direct association with the Gensini score (β=-0.213, p <0.001), and an indirect association through negative metabolic syndrome (β=-0.019, p =0.022), controlled for gender, physical activity, and perceived stress scale., Conclusions: The severity of CAD was directly associated with the unhealthy DP and indirectly mediated by the presence of the metabolic syndrome, while a healthy DP had a direct inverse association with CAD severity and indirectly mediated by the absence of metabolic syndrome.

Background: The association of dietary patterns (DPs) linked to the severity of coronary artery disease (CAD) is little known. Therefore, this study aims to explore the relationship between major DPs and the severity of CAD., Methods: This cross-sectional study was conducted among423 newly discovered CAD patients (both genders, aged 35-65 years), who underwent coronary angiography. The severity of CAD was assessed by the Gensini score. All patients were tested using a semi-quantitative food frequency questionnaire and other related data through face-to-face interviews. Factor analysis and logistic regression were applied by using SPSS version-24., Results: By principal component analysis, two major DPs were identified: "Unhealthy" DP that characterized mainly by high intakes of sugar and sweets, soft drinks, salts, cooking oils, and processed meats, and "Healthy" DP that consisting high intakes of fruits, fish, poultry, vegetables, whole grains. After adjustment for confounding variables, the odds of severe CAD was significantly higher in the third (T3) and second (T2) tertile of the unhealthy pattern by 4.79 and 2.48 times more compared to the first tertile (T1) (OR 4.79; 95%CI 2.60, 8.83; P<0.001) and (OR 2.48; 95%CI 1.40, 4.39; P=0.002), respectively. However, the odds of CAD severity in the T3 and T2 of the healthy pattern was lowered by 0.24 and 0.38 times less compared to the T1 (OR 0.24; 95%CI 0.12, 0.47; P=0.002) and (OR 0.38; 95%CI 0.20, 0.73; P=0.006), respectively., Conclusion: The severity of CAD was significantly increased by the unhealthy dietary pattern, while decreased by adherence to the healthy pattern., (© 2021 Mohamed K., et al.)

Background/aim: In the present study, we aimed to investigate the relationship between NT-proBNP and SYNTAX score, which is a measure of the complexity of coronary artery disease., Materials and Methods: We enrolled 405 consecutive patients with myocardial infarction who underwent coronary angiographic examination. Patients were divided into 3 groups according to their SYNTAX scores. Those with SYNTAX score ≤22 were included in the low SYNTAX score group (LSTX), those with a score of 23–32 were included in the intermediate SYNTAX score group (ISTX), and those with a score of ≥33 were included in the high SYNTAX score group (HSTX)., Results: NT-proBNP levels were found to be significantly higher in the HSTX group compared to the other groups (P < 0.001) and in the ISTX group compared to the LSTX group (P < 0.001). The NT-proBNP levels demonstrated an increase from low SYNTAX score to high SYNTAX score tertiles., Conclusions: NT-ProBNP levels in patients with myocardial infarction on admission were independently associated with extent, severity, and complexity of coronary atherosclerosis as assessed by SYNTAX score., Competing Interests: none declared, (This work is licensed under a Creative Commons Attribution 4.0 International License.)

Recent genome-wide association studies identified the common genetic variants in 9p21 were associated with the coronary artery disease (CAD). However, whether this locus could predict the severity of CAD in Chinese Han population is unclear. 499 CAD patients who underwent coronary angiography (CAG) have been enrolled for this study. The single-nucleotide polymorphisms rs2383207 and rs2383206 in 9p21 were genotyped in 499 CAG cases and 1519 controls in Chinese Han population. The gene dosage of 9p21 was stratified by the degree of vascular lesions and tested for association with the severity of CAD. Rs2383207 and rs2383206 demonstrated significant associations with 2-vessel and 3-vessel disease (P = 2.0×10(-3) and 1.9×10(-4) , respectively). GG genotypes of rs2383206 occurred higher proportion of left main trunk (LM) disease (P = 6.0×10(-3) ). GG genotypes of rs2383207 occurred higher proportion of left anterior descending artery disease (LAD) and right CAD (RCA) (P = 2.7×10(-6) and 1.6×10(-4) , respectively). The risk allele G of rs2383207 was associated with severity of CAD estimated by the Gensini score (P = 3.6×10(-5) ). Rs2383207 may strongly influence the development of CAD in Chinese Han population. The gene dosage in 9p21 could predict the severity of CAD., (© 2016 John Wiley & Sons Ltd/University College London.)

Aim To investigate the correlation between triglyceride-glucose (TyG) index and the severity of coronary artery disease assessed in patients with acute myocardial infarction (AMI). Methods The study restrospectively selected 424 patients with AMI in the Fourth Affiliated Hospital of Xinjiang Medical University from January 2020 to March 2023. Clinical data and results of coronary angiography (CAG) were collected. Gensini score was used to quantitatively assess the degree of coronary artery stenosis. According to tertiles of the Gensini, the patients were classified into three groups: low Gensini score group (<45 points, n =140), medium Gensini score group (45 ~ 86 points, n =143), and high Gensini score group (≥87 points, n =141). The associations between TyG index and the occurrence of coronary artery disease with high Gensini score by Logistic regression analysis; Spearman correlation was used to analyze the correlation between TyG index and Gensini score in AMI patients; ROC curve was used to analyze the value of TyG index in predicting the severity of coronary artery lesions. Results TyG index of high Gensini score group was significantly higher than that of low and medium Gensini score group (P<0. 05). Logistic regression analysis showed that TyG index was an independent risk factor for severe coronary lesions in AMI patients (OR=13. 327, 95%CI: 2. 642 ~67. 235, P =0. 002). Spearman correlation analysis showed that TyG index was positively correlated with the severity of coronary artery disease (r =0. 331, P<0. 001). ROC curve analysis showed that the area under curve of TyG index was 0. 680 (95%CI: 0. 630 ~0. 731, P<0. 001). When the cut-off value of TyG index was 1. 555, the predicted efficacy of of severe coronary artery disease in patients with AMI was the highest, with a sensitivity of 79. 4% and a specificity of 50. 5%. Conclusion TyG, as a novel biomarker, was significantly and independently associated with the severity of the coronary arteries in patients with AMI. [ABSTRACT FROM AUTHOR]

Aim To explore the correlation between platelet morphology parameters and the severity of coronary artery disease in patients with acute coronary syndrome (ACS). Methods 121 ACS patients who were hospitalized in the Department of Cardiovascular Medicine of Second Affiliated Hospital of University of South China from January 2019 to October 2019 were selected, and 35 patients with normal results of selective coronary angiography during the same period were selected as the control group. Mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (PLCR) were used as platelet morphology parameters. All patients underwent coronary angiography and were divided into low score (1 ~ 40 points) group, medium score (41 ~ 80 points) group, and high score (81 points and above) group. The differences in platelet morphology parameters between each group were compared to identify risk factors for high Gensini scores. Results The MPV, PDW, PLCR, male proportion, creatine kinase isoenzyme (CK-MB), N-terminal-pro brain natriuretic peptide (NT-proBNP), uric acid (UA), and cardiac troponin I (cTnI) in the ACS group were significantly higher than those in the control group (P<0. 05). PDW, MPV and PLCR gradually increased in the control group and Gensini low, medium, and high score groups (P <0. 05). Pearson correlation analysis showed a positive correlation between PDW(r =0. 814, P<0. 05), MPV (r =0. 822, P<0. 05), PLCR (r =0. 802, P<0. 05) and Gensini score. Multiple Logistic regression analysis showed that PLCR can be a risk factor for high coronary Gensini score. Conclusion PLCR, PDW and MPV are positively correlated with the severity of coronary artery disease in patients with ACS, and have potential importance in evaluating the severity of coronary artery disease. [ABSTRACT FROM AUTHOR]

Background: Non-ST-segment elevation Acute Cronary Syndrome (NSTE-ACS) stays as the most common cause of mortality in people with cronary artery disease (CAD). Objective: The purpose of this research was to assess the probable association between the severity of CAD disease (by using the Syntax score) and c-reactive protein/albumin ratio (CAR) calculated by measuring serum levels upon admission. Patients and Methods: A prospective study that included 100 patients who were admitted to Agoza Hospital and Benha University Hospital with clinical features of NSTEMI and treated with percutaneous coronary intervention (PCI). We divided the patients into 2 groups: according to Syntax score, group 1 included 59 patients with Syntax score = 22. Group 2 included 41 patients with Syntax score > 22. Results: Regarding laboratory findings in the studied patients, neutrophil was significantly higher in group 2 (7.6) than in group 1 (6) (P < 0.001). Platelets were significantly higher in group 2 (332%) than in group 1 (293) (P < 0.001). Median CRP was significantly higher in group 2 (14.8) than in group 1 (6) (P < 0.001). Median CAR was significantly higher in Group 2 (35.6) than in group 1 (14.6) (P < 0.001). Neutrophil to lymphocyte ratio (NLR) was significantly higher in group 2 (3) than in group 1 (2.5) P < 0.001). Left main cronary artery (LMCA) disease, three vessels disease (3VD), bifurcation, complete total occlusion (CTO), Lesion > 20 mm and severe tortuosity were significantly higher in group 2 than in group 1. Conclusion: GRS, LMCA disease, TVD, bifurcation, CTO, Lesion > 20 mm, severe tortuosity, neutrophil, platelets, median CRP, median CAR and NLR were significantly higher in those with Syntax score > 22 than those with syntax score = 22. CAR was revealed to be an independent predictor for the high SS group, with a stronger correlation to the complexity and severity of CAD. [ABSTRACT FROM AUTHOR]

Aim: Patients with acute coronary syndrome who underwent percutaneous coronary intervention (PCI) constitute the group with the highest risk of contrast-induced nephropathy development. Contrast media exposure might increase in patients who have lesions with >70% stenosis in the major epicardial arteries. Also, the impaired kidney function is associated with severity of coronary artery disease. We evaluated the relationship with severity of coronary artery disease (CAD) calculated by Gensini score and contrast induced nephropathy (CIN) in patients with mild renal insufficiency in acute coronary syndrome (ACS). Material and Methods: We enrolled 227 patients with ACS who underwent percutaneous coronary intervention. Patients were divided into groups according to CIN development. Severity of CAD was evaluated by Gensini score. Logistic regression analysis (univariate and multivariate) was performed to evaluate the predictors of CIN using variables that are clinically related to CIN. The 95% confidence interval (CI) and odds ratios (OR) were presented. Receiver–operating characteristic (ROC) curve was performed to demonstrate the sensitivity and specificity of the Gensini score. Results: A total of 69 (30.1%) patients with ACS had CIN. Compared to CIN (-) patients, CIN (+) patients had higher Gensini score, incidence of diabetes mellitus and amount of contrast media. Multivariate logistic regression analyses demonstrated that Gensini score, DM and amount of contrast media were independent risk factors for CIN development (p < 0.05 for all parameters). Conclusion: Gensini score, which simply shows severity of CAD, may be helpful in the determination of CIN risk in patients with ACS. [ABSTRACT FROM AUTHOR]