1. NT-ProBNP Independently Predicts Long-Term Mortality in Patients Admitted for Coronary Angiography.
- Author
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Ruwald, Martin Huth, Goetze, Jens Peter, Bech, Jan, Nielsen, Olav Wendelboe, Madsen, Bente Kühn, Nielsen, Lars Bo, Mouridsen, Mette, Ruwald, Anne-Christine Huth, Madsen, Jan Kyst, and Pedersen, Sune
- Subjects
AGE distribution ,BIOMARKERS ,CONFIDENCE intervals ,CORONARY disease ,PEPTIDE hormones ,SURVIVAL analysis (Biometry) ,T-test (Statistics) ,U-statistics ,DATA analysis software ,DESCRIPTIVE statistics ,KAPLAN-Meier estimator ,CORONARY angiography ,PROGNOSIS - Abstract
Recently, research interests are focussed on biomarkers to predict the outcome in patients with coronary artery disease (CAD). We examined whether the levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) could predict outcome in patients who underwent elective or acute coronary angiography (CAG). A total of 337 patients with suspected CAD who underwent elective or acute CAG were followed up for a mean period of 6.7 years. Primary end points were all-cause mortality (ACM) and the combined end point of ACM, nonfatal myocardial infarction, and revascularization. In all, 53 (16%) patients died and 88 (26%) patients reached the combined end point. Preprocedural NT-proBNP above 32 pmol/L independently predicted ACM (hazard ratio [HR] 3.11; confidence interval [CI]: 1.60-6.07; P = .001) and the combined end point (HR 2.44 [CI: 1.50-3.97]; P < .001). This study indicates that high NT-proBNP is an independent predictor of ACM on long-term follow-up. N-terminal-proBNP is a reliable predictive marker of mortality in the setting of stable or unstable angina. [ABSTRACT FROM PUBLISHER]
- Published
- 2014
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