1. Parkinson's Disease in Light of the COVID-19 Pandemic.
- Author
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Drelich-Zbroja, Anna, Cheda, Mateusz, Kuczyńska, Maryla, Dąbrowska, Izabela, Kopyto, Ewa, and Halczuk, Izabela
- Subjects
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SARS-CoV-2 , *CORONAVIRUS diseases , *COUGH , *PARKINSON'S disease , *COVID-19 pandemic , *COVID-19 , *MUSCLE rigidity - Abstract
In this review we attempt to collate the existing scientific evidence regarding the possible role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the pathophysiology of Parkinson's disease (PD), as well as to investigate the impact of PD/parkinsonism on the clinical course of the viral infection itself. Since etiology of PD is not completely understood, various studies suggest different potential links between coronavirus disease 2019 (COVID-19) and PD. Suggested connections include, among others, similar prodromal symptoms, renin–angiotensin–aldosterone system involvement, or gut microbiome dysbiosis participation. Despite the initial assumptions that, as a mainly elderly population suffering from rigidity of respiratory muscles, impairment of cough reflex, and dyspnea, PD patients would be more susceptible to viral infection, and would experience a more aggressive course of COVID-19, the published scientific reports contain mutually exclusive data that require further investigation and meta-analysis. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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