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Background: Severe pneumonia is pathological manifestation of Coronavirus Disease 2019 (COVID-19), however complications have been reported in COVID-19 patients with a worst prognosis. Aim of this study was to evaluate the role of high sensitivity cardiac troponin I (hs-TnI) in patients with SARS-CoV-2 infection., Methods: we retrospectively analysed hs-TnI values measured in 523 patients (median age 64 years, 68% men) admitted to a university hospital in Milan, Italy, and diagnosed COVID-19., Results: A significant difference in hs-TnI concentrations was found between deceased patients (98 patients) vs discharged (425 patients) [36.05 ng/L IQR 16.5-94.9 vs 6.3 ng/L IQR 2.6-13.9, p  < 0.001 respectively]. Hs-TnI measurements were independent predictors of mortality at multivariate analysis adjusted for confounding parameters such as age (HR 1.004 for each 10 point of troponin, 95% CI 1.002-1.006, p  < 0.001). The survival rate, after one week, in patients with hs-TnI values under 6 ng/L was 97.94%, between 6 ng/L and the normal value was 90.87%, between the normal value and 40 ng/L was 86.98, and 59.27% over 40 ng/L., Conclusion: Increase of hs-TnI associated with elevated mortality in patients with COVID-19. Troponin shows to be a useful biomarker of disease progression and worse prognosis in COVID-19 patients.

The recent COVID-19 pandemic and related social distancing measures have significantly changed worldwide employment conditions. In developed economies, institutions and organizations, both public and private, are called upon to reflect on new organizational models of work and human resource management, which - in fact - should offer workers sufficient flexibility in adapting their work schedules remotely to their personal (and family) needs. This study aims to explore, within a Job Demands-Resources framework, whether and to what extent job demands (workload and social isolation), organizational job resources (perceived organizational support), and personal resources (self-efficacy, vision about the future and commitment to organizational change) have affected workers' quality of life during the pandemic, taking into account the potential mediating role of job satisfaction and perceived stress. Using data from a sample of 293 workers, we estimate measurement and structural models, according to the Item Response Theory and the Path analysis frameworks, which allow us to operationalize the latent traits and study the complex structure of relationships between the latent dimensions. We inserted in the model as control variables, the socio-economic and demographic characteristics of the respondents, with particular emphasis on gender differences and the presence and age of children. The study offers insights into the relationship between remote work and quality of life, and the need to rethink human resource management policies considering the opportunities and critical issues highlighted by working full-time remotely. [ABSTRACT FROM AUTHOR]

Due to the coronavirus disease 2019 (COVID-19) epidemic, global economies have suffered an exogenous shock never seen before with a strong economic and psychosocial impact on organizations. Italy, in the context of the research, has been severely affected. The economic crisis has mainly affected women. In this scenario, entrepreneurial perceived success (objective and subjective) is influenced by increasingly burdensome job demands that entrepreneurs have to face up. Using the job demand-resources model, the study aims to broaden the knowledge of the determinants of entrepreneurial perceived success in the current emergency moment. In particular, as regards of the demands, alongside the specific entrepreneurial demands (time demands, uncertainty and risk, and responsibility), we also decided to include the negative interface family–work in both directions from-family-to-work (NEGWIF) and from-work-to-family (NEGFIW). Regarding the resources, we considered entrepreneurial self-efficacy (researching, planning, marshaling, implementing people, and implementing financial), proactive and elaborate social strategies (SS), and both directions of the positive interface: from-family-to-work (POSWIF) and from-work-to-family (POSFIW). All participants are women entrepreneurs (N = 137) who have completed a self-report questionnaire. We explored the associations between demands, resources, and the dimensions of success through hierarchical regressions. As for the demands, time demands, uncertainty and risk, NEGWIF, and NEGFIW negatively influenced the perceived entrepreneurial success. Regarding resources, planning, implementing financial, proactive and elaborate SS positively influenced the perceived entrepreneurial success. [ABSTRACT FROM AUTHOR]