1. A cross-sectional study evaluating hospitalization rates for chronic limb-threatening ischemia during the COVID-19 outbreak in Campania, Italy.
- Author
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Stabile E, Piccolo R, Franzese M, Accarino G, Bracale UM, Cappello E, Cioffi G, Cioppa A, Crinisio A, Flora L, Landino P, Martelli E, Mancusi R, Niola R, Petrosino F, Razzano D, Ruotolo C, Salemme L, Sangiuolo P, Santini G, Soreca E, Vigliotti G, Villari B, Amabile G, Ammollo RP, Barbarisi D, Corbisiero AM, D'angelo A, Cangiano G, De Gregorio C, De Laurentis M, Laurenzano E, Ficarelli I, Luongo A, Molino C, Sarti G, Viola D, and Esposito G
- Subjects
- Adult, Aged, Aged, 80 and over, Chronic Disease, Cross-Sectional Studies, Female, Humans, Ischemia physiopathology, Ischemia virology, Italy epidemiology, Male, Middle Aged, Peripheral Arterial Disease complications, Peripheral Arterial Disease virology, Retrospective Studies, Risk Factors, COVID-19 epidemiology, COVID-19 virology, Extremities physiopathology, Hospitalization statistics & numerical data, Ischemia epidemiology, SARS-CoV-2 pathogenicity
- Abstract
The expansion of coronavirus disease 2019 (COVID-19) prompted measures of disease containment by the Italian government with a national lockdown on March 9, 2020. The purpose of this study is to evaluate the rate of hospitalization and mode of in-hospital treatment of patients with chronic limb-threatening ischemia (CLTI) before and during lockdown in the Campania region of Italy. The study population includes all patients with CLTI hospitalized in Campania over a 10-week period: 5 weeks before and 5 weeks during lockdown ( n = 453). Patients were treated medically and/or underwent urgent revascularization and/or major amputation of the lower extremities. Mean age was 69.2 ± 10.6 years and 27.6% of the patients were women. During hospitalization, 21.9% of patients were treated medically, 78.1% underwent revascularization, and 17.4% required amputations. In the weeks during the lockdown, a reduced rate of hospitalization for CLTI was observed compared with the weeks before lockdown (25 vs 74/100,000 inhabitants/year; incidence rate ratio: 0.34, 95% CI 0.32-0.37). This effect persisted to the end of the study period. An increased amputation rate in the weeks during lockdown was observed (29.3% vs 13.4%; p < 0.001). This study reports a reduced rate of CLTI-related hospitalization and an increased in-hospital amputation rate during lockdown in Campania. Ensuring appropriate treatment for patients with CLTI should be prioritized, even during disease containment measures due to the COVID-19 pandemic or other similar conditions.
- Published
- 2021
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