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Your search keyword '"M. Vedrenne"' showing total 3 results
Start Over Author "M. Vedrenne" Topic covid-19
3 results on '"M. Vedrenne"'

1. Pathophysiological pathway differences in children who present with COVID-19 ARDS compared to COVID -19 induced MIS-C.

Author

McCafferty C, Cai T, Borgel D, Lasne D, Renolleau S, Vedrenne-Cloquet M, Bonnet D, Wu J, Zaw T, Bhatnagar A, Song X, Van Den Helm S, Letunica N, Attard C, Karlaftis V, Praporski S, Ignjatovic V, and Monagle P

Subjects
Complement System Proteins, Humans, Proteomics methods, Systemic Inflammatory Response Syndrome, COVID-19 complications, Respiratory Distress Syndrome
Abstract

COVID-19 has infected more than 275 million worldwide (at the beginning of 2022). Children appear less susceptible to COVID-19 and present with milder symptoms. Cases of children with COVID-19 developing clinical features of Kawasaki-disease have been described. Here we utilise Mass Spectrometry proteomics to determine the plasma proteins expressed in healthy children pre-pandemic, children with multisystem inflammatory syndrome (MIS-C) and children with COVID-19 induced ARDS. Pathway analyses were performed to determine the affected pathways. 76 proteins are differentially expressed across the groups, with 85 and 52 proteins specific to MIS-C and COVID-19 ARDS, respectively. Complement and coagulation activation are implicated in these clinical phenotypes, however there was significant contribution of FcGR and BCR activation in MIS-C and scavenging of haem and retinoid metabolism in COVID-19 ARDS. We show global proteomic differences in MIS-C and COVID-ARDS, although both show complement and coagulation dysregulation. The results contribute to our understanding of MIS-C and COVID-19 ARDS in children., (© 2022. The Author(s).)

Published
2022
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2. Cranial polyneuropathy as the first manifestation of a severe COVID-19 in a child.

Author

Roussel A, Germanaud D, Bouchoucha Y, Ouldali N, Vedrenne-Cloquet M, Castelle M, and Baruchel A

Subjects
Anemia, Sickle Cell complications, Child, Epstein-Barr Virus Infections complications, Epstein-Barr Virus Infections drug therapy, Febrile Neutropenia complications, Febrile Neutropenia drug therapy, Female, Hematopoietic Stem Cell Transplantation methods, Herpes Simplex complications, Herpes Simplex drug therapy, Humans, Mucositis complications, Mucositis drug therapy, Polyneuropathies virology, SARS-CoV-2, Vasculitis, Central Nervous System pathology, COVID-19 pathology, Cranial Nerves pathology, Polyneuropathies pathology, Polyneuropathies therapy
Published
2021
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3. Severe and fatal forms of COVID-19 in children

Author

Mehdi Oualha, Elodie Salvador, M. Vedrenne, L. de Saint Blanquat, L. Dupic, F. Lesage, C. Heilbronner, Alice Corsia, David Drummond, Florence Moulin, C. de Marcellus, M. Bendavid, G. Chéron, Y. Pinhas, Marion Grimaud, Romain Berthaud, Judith Chareyre, François Angoulvant, Jacques Fourgeaud, Laureline Berteloot, Sylvain Renolleau, Julie Toubiana, Pierre Frange, M. Castelle, Université de Paris (UP), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Université Paris Cité (UPC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPC)

Subjects
Male, Paris, Pediatrics, medicine.medical_specialty, Adolescent, Coronavirus disease 2019 (COVID-19), medicine.medical_treatment, [SDV]Life Sciences [q-bio], Pneumonia, Viral, coronavirus, India, Comorbidity, Disease, Severity of Illness Index, Article, Betacoronavirus, 03 medical and health sciences, COVID-19 Testing, 0302 clinical medicine, Risk Factors, 030225 pediatrics, medicine, Extracorporeal membrane oxygenation, Humans, Pediatrics, Perinatology, and Child Health, 030212 general & internal medicine, Renal replacement therapy, Disease management (health), Child, Pandemics, Demography, Retrospective Studies, Mechanical ventilation, Past medical history, Clinical Laboratory Techniques, SARS-CoV-2, business.industry, COVID-19, Infant, Prognosis, 3. Good health, Child, Preschool, Pediatrics, Perinatology and Child Health, Disease Progression, Female, Observational study, Coronavirus Infections, business, Scientific Letter
Abstract

Objectives The aim of this study was to describe severe forms of novel coronavirus disease 2019 in children, including patient characteristics, clinical, laboratory, and imaging findings, as well as the disease management and outcomes. Methods This was a retrospective, single-center, observational study conducted in a pediatric intensive and high-dependency care unit (PICU, HDU) in an urban hospital in Paris. All patients, aged from 1 month to 18 years, admitted for confirmed or highly suspected SARS-CoV-2 were included. Results We analyzed the data of 27 children. Comorbidities (n = 19, 70%) were mainly neurological (n = 7), respiratory, (n = 4), or sickle cell disease (n = 4). SARS-CoV-2 PCR results were positive in 24 children (nasopharyngeal swabs). The three remaining children had a chest CT scan consistent with COVID-19. Respiratory involvement was observed in 24 patients (89%). Supportive treatments were invasive mechanical ventilation (n = 9), catecholamine (n = 4), erythropheresis (n = 4), renal replacement therapy (n = 1), and extracorporeal membrane oxygenation (n = 1). Five children died, of whom three were without past medical history. Conclusion This study highlighted the large spectrum of clinical presentation and time course of disease progression as well as the non-negligible occurrence of pediatric life-threatening and fatal cases of COVID-19 mostly in patients with comorbidities. Additional laboratory investigations are needed to further analyze the mechanism underlying the variability of SARS-Cov-2 pathogenicity in children.

Published
2020
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