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5 results on '"Pembegül, İrem"'

1. Differential diagnosis of COVID-19 pneumonia from acute heart failure in pandemic: Importance of radiological and laboratory findings.

Author

Kasapoğlu US, Gök A, Acun Delen L, Şayan H, Kaçmaz O, Çağasar Ö, Karaca R, Güneş A, Pembegül İ, and Yalçınsoy M

Subjects
Acute Disease, Aged, COVID-19 epidemiology, Diagnosis, Differential, Female, Humans, Male, Retrospective Studies, COVID-19 diagnosis, Heart Failure diagnosis, Lung diagnostic imaging, Pandemics, SARS-CoV-2, Tomography, X-Ray Computed methods
Abstract

Introduction: COVID-19 pneumonia typically presents with high fever, cough, and shortness of breath and on thorax computed tomography (CT) peripheral ground glass opacities help the diagnosis. Although typical imaging findings for COVID-19 pneumonia are specified in thorax CT, these findings can be confused with other diseases. The aim of this study is to investigate the roles of radiological imaging and laboratory findings in the differential diagnosis of COVID-19 pneumonia and acute heart failure (AHF)., Materials and Methods: In the present study, 74 patients who admitted to the emergency department with respiratory distress during the pandemic period and received a diagnosis of COVID-19 pneumonia and AHF were included. Laboratory data and radiological findings of the patients, at the time of admission, were evaluated., Result: On admission, there was no difference in age, gender between two groups. However, COVID-19 exposure history was found significantly higher in COVID-19 pneumonia patients group (p<0.001). Fever, cough, and fatigue were found significantly higher in the COVID-19 pneumonia patients group (p<0.001). There was difference of lesions distribution between the two groups, centrally distributed lesions were found significantly higher in acute heart failure patients (p<0.001). Pleural effusion and cardiomegaly were found significantly higher in AHF patients (p<0.001, p<0.001). Counts of the white blood cells and lymphocytes were found significantly lower in COVID-19 pneumonia patients (p= 0.003, p= 0.009). COVID-19 pneumonia patients had significantly higher levels of CRP, ferritin, LDH and CK compared with AHF patients (p<0.001, p<0.001, p= 0.002, p= 0.013). However the level of NT-proBNP was found significantly higher in the AHF patients group (p<0.001)., Conclusions: We believe that laboratory data and thorax CT findings can provide beneficial clinical information in differentiating COVID-19 pneumonia from AHF during the pandemic.

Published
2021
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2. Post-COVID-19 Outcomes of Patients with Primary Glomerular Diseases: A Nationwide Controlled Study.

Author

Öztürk, Savaş, Karadağ, Serhat, Arıcı, Mustafa, Türkmen, Aydın, Turgutalp, Kenan, Aktaş, Nimet, Kazancıoğlu, Rümeyza, Kuzu, Tolga, Öztürk, İlyas, Aydın, Zeki, Ayar, Yavuz, Mutluay, Rüya, Ebinç, Fatma Ayerden, Pınar, Musa, Bastürk, Taner, Yılmaz, Fatih, İnci, Ayça, Trabulus, Sinan, Ural, Zeynep, and Pembegül, İrem

Subjects
KIDNEY glomerulus diseases, COVID-19 pandemic, COVID-19, RENAL replacement therapy, CHRONIC kidney failure, TERMINALLY ill, GOVERNORS
Abstract

Background: Patients with chronic diseases such as chronic kidney disease (CKD) have been reported to have more adverse outcomes during the coronavirus disease 2019 (COVID-19) pandemic. There are insuficient data on the outcomes of patients with primary glomerular diseases (PGD) afer COVID-19. Methods: We designed a national multicenter observational study that included adult patients with biopsy-proven PGD who survived COVID-19. A control group was created from the same centers, including PGD patients without COVID-19. The clinical and laboratory data of the patients at baseline, frst, and third months afer COVID-19 were recorded. Results: A total of 129 patients from 21 centers were included (COVID-19 group, n = 77). Baseline characteristics were almost similar except the ratio of active disease in the non-COVID-19 group was signifcantly higher than in the COVID-19 group. No patients died during the frst and third months. Respiratory symptoms were signifcantly higher in the COVID-19 group than in the non-COVID-19 group in the frst month (7.8% vs. 0%, P = .039). All other follow-up outcomes, including initiation of chronic kidney replacement therapy and initiation of new immunosuppressive treatment, and the laboratory data were not diferent between the groups in the frst and third months. Conclusion: Primary glomerular disease patients in the post-COVID-19 period had more respiratory symptoms than non-COVID-19 PGD patients, but outcomes, including death and initiation of kidney replacement therapy, were not diferent in the frst and third months post COVID-19. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Differential diagnosis of COVID-19 pneumonia from acute heart failure in pandemic: Importance of radiological and laboratory findings

Author

Murat Yalçinsoy, İrem Pembegül, Hasan Şayan, Rukan Karaca, Ozlem Cagasar, Osman Kaçmaz, Abdullah Gök, Umut Sabri Kasapoğlu, Ajda Güneş, Leman Acun Delen, and Pembegül, İrem

Subjects
Male, Pulmonary and Respiratory Medicine, Thorax, medicine.medical_specialty, Pleural effusion, Critical Care and Intensive Care Medicine, Diagnosis, Differential, Internal medicine, medicine, Humans, Computed tomography, Lung, Pandemics, Aged, Retrospective Studies, Heart Failure, Respiratory distress, SARS-CoV-2, business.industry, Acute heart failure, COVID-19, Retrospective cohort study, Pneumonia, Emergency department, medicine.disease, respiratory tract diseases, Ground glass opacity, Heart failure, Acute Disease, Female, Surgery, Differential diagnosis, Tomography, X-Ray Computed, business
Abstract

Introduction: COVID-19 pneumonia typically presents with high fever, cough, and shortness of breath and on thorax computed tomography (CT) peripheral ground glass opacities help the diagnosis. Although typical imaging findings for COVID-19 pneumonia are specified in thorax CT, these findings can be confused with other diseases. The aim of this study is to investigate the roles of radiological imaging and laboratory findings in the differential diagnosis of COVID-19 pneumonia and acute heart failure (AHF). Materials and Methods: In the present study, 74 patients who admitted to the emergency department with respiratory distress during the pandemic period and received a diagnosis of COVID-19 pneumonia and AHF were included. Laboratory data and radiological findings of the patients, at the time of admission, were evaluated. Result: On admission, there was no difference in age, gender between two groups. However, COVID-19 exposure history was found significantly higher in COVID-19 pneumonia patients group (p

Published
2021
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4. The Longitudinal Evolution of Post-COVID-19 Outcomes Among Hemodialysis Patients in Turkey

Author

Savas Ozturk, Kenan Turgutalp, Mustafa Arici, Numan Gorgulu, Halil Zeki Tonbul, Necmi Eren, Vedat Gencer, Mehmet Deniz Ayli, Irem Pembegul, Murside Esra Dolarslan, Zeynep Ural, Hulya Colak, Tuba Elif Ozler, Ozgur Can, Mehmet Emin Demir, Orcun Altunoren, Bulent Huddam, Kursad Onec, Bulent Demirelli, Zeki Aydin, Eda Altun, Selma Alagoz, Yavuz Ayar, Zeynep Ebru Eser, Bayram Berktas, Zulfukar Yilmaz, Eser Uslu Ates, Enver Yuksel, Gizem Kumru Sahin, Merve Aktar, Egemen Cebeci, Belda Dursun, Sibel Yucel Kocak, Abdulmecit Yildiz, Sinan Kazan, Mahmut Gok, Erkan Sengul, Murat Tugcu, Ramazan Ozturk, Serdar Kahvecioglu, Ekrem Kara, Bulent Kaya, Garip Sahin, Tamer Sakaci, Savas Sipahi, Ilhan Kurultak, Beyza Algul Durak, Mehmet Riza Altiparmak, Sabahat Alisir Ecder, Serhat Karadag, Mevlut Tamer Dincer, Hakan Ozer, Sibel Gokcay Bek, Memnune Sena Ulu, Ozkan Gungor, Elif Ari Bakir, Ali Riza Odabas, Nurhan Seyahi, Alaattin Yildiz, Kenan Ates, Pembegül, İrem, MÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Huddam, Bülent, RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, and Kara, Ekrem

Subjects
Mortality-Rates, hemodialysis, Nephrology, Hemodialysis, Nationwide study, outcome, COVID-19, OVID-19, nationwide study, Transplant, Outcome
Abstract

Introduction: Hemodialysis (HD) patients have increased risk for short-term adverse outcomes of COVID-19. However, complications and survival at the post-COVID-19 period have not been published extensively.Methods: We conducted a national, multicenter observational study that included adult maintenance HD patients recovered from confirmed COVID-19. A control HD group without COVID-19 was selected from patients in the same center. We investigated the characteristics and outcomes in the follow-up of HD patients and compare them with the non-COVID-19 group.Results: A total of 1223 patients (635 patients in COVID-19 group, 588 patients in non-COVID-19 group) from 47 centers were included in the study. The patients' baseline and HD characteristics were almost similar. The 28th-day mortality and mortality between 28th day and 90th day were higher in the COVID-19 group than non-COVID-19 group (19 [3.0%] patients vs. none [0%]; 15 [2.4%] patients vs. 4 [0.7%] patients, respectively). The presence of respiratory symptoms, rehospitalization, need for home oxygen therapy, lower respiratory tract infection, and arteriovenous (AV) fistula thrombosis was significantly higher in the COVID-19 group in both the first 28 days and between 28 and 90 days. In the multivariable analysis, age (odds ratio [OR] [95% CI]: 1.029 [1.004-1.056]), group (COVID-19 group vs. non-COVID-19 group) (OR [95% CI]: 7.258 [2.538-20.751]), and vascular access type (tunneled catheter/AV fistula) (OR [95% CI]: 2.512 [1.249-5.051]) were found as independent parameters related to 90-day mortality.Conclusion: In the post-COVID-19 period, maintenance HD patients who have had COVID-19 have increased rehospitalization, respiratory problems, vascular access problems, and high mortality compared with the non-COVID-19 HD patients.

Published
2022

5. Characteristics and outcomes of hospitalised older patients with chronic kidney disease and COVID‐19: A multicenter nationwide controlled study

Author

Numan Gorgulu, Ekrem Kara, Bulent Tokgoz, Dilek Guven Taymez, Halil Zeki Tonbul, Ender Hur, Murside Esra Dolarslan, İrem Pembegül, Mustafa Arici, Zubeyde Serhan Tuglular, İdris Şahin, Mahmud Islam, Alaattin Yildiz, Gülizar Şahin, Taner Basturk, Kenan Ates, Mehmet Riza Altiparmak, Zeki Aydin, Mahmut Gok, Hamad Dheir, Zeki Soypacaci, Serhat Karadag, Siren Sezer, Necmi Eren, Kenan Turgutalp, Garip Sahin, Ali Riza Odabas, Serkan Bakirdogen, Barış Döner, Mehmet Deniz Ayli, Tuba Elif Ozler, Melike Betul Ogutmen, Savas Ozturk, Erkan Sengul, RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kara, Ekrem, Pembegül, İrem, Ozturk, Savas, Turgutalp, Kenan, Arici, Mustafa, Gok, Mahmut, Islam, Mahmud, Altiparmak, Mehmet Riza, Aydin, Zeki, Doner, Baris, Eren, Necmi, Sengul, Erkan, Karadag, Serhat, Ozler, Tuba Elif, Dheir, Hamad, Pembegul, Irem, Taymez, Dilek Guven, Sahin, Garip, Bakirdogen, Serkan, Dolarslan, Murside Esra, Soypacaci, Zeki, Hur, Ender, Basturk, Taner, Ogutmen, Melike Betul, Gorgulu, Numan, Sahin, Idris, Ayli, Mehmet Deniz, Tuglular, Zubeyde Serhan, Sahin, Gulizar, Tokgoz, Bulent, Tonbul, Halil Zeki, Yildiz, Alaattin, Sezer, Siren, Odabas, Ali Riza, and Ates, Kenan

Subjects
Nephrology, HEMODIALYSIS, medicine.medical_treatment, kidney disease, Renal-diasease, 030204 cardiovascular system & hematology, law.invention, 0302 clinical medicine, COVID-19 Testing, law, Risk Factors, INFECTION, 030212 general & internal medicine, POPULATION, RISK, Mortality rate, Hazard ratio, DEATH, General Medicine, Middle Aged, Intensive care unit, Original Papers, Death, Hospitalization, Hemodialysis, Female, Covid-19, Infection, Risk, medicine.medical_specialty, Population, 03 medical and health sciences, Internal medicine, medicine, Humans, Mortality, Renal Insufficiency, Chronic, Aged, Retrospective Studies, Original Paper, business.industry, SARS-CoV-2, MORTALITY, COVID-19, Retrospective cohort study, medicine.disease, Confidence interval, RENAL-DISEASE, business, Renal-Disease, Kidney disease
Abstract

Objective Older adults with co‐morbidities have been reported to be at higher risk for adverse outcomes of coronavirus disease 2019 (COVID‐19). The characteristics of COVID‐19 in older patients and its clinical outcomes in different kidney disease groups are not well known. Methods Data were retrieved from a national multicentric database supported by Turkish Society of Nephrology, which consists of retrospectively collected data between 17 April 2020 and 31 December 2020. Hospitalised patients aged 18 years or older with confirmed COVID‐19 diagnosis suffering from stage 3‐5 chronic kidney disease (CKD) or on maintenance haemodialysis (HD) treatment were included in the database. Non‐uraemic hospitalised patients with COVID‐19 were also included as the control group. Results We included 879 patients [388 (44.1%) female, median age: 63 (IQR: 50‐73) years]. The percentage of older patients in the CKD group was 68.8% (n = 188/273), in the HD group was 49.0% (n = 150/306) and in the control group was 30.4% (n = 70/300). Co‐morbidities were higher in the CKD and HD groups. The rate of presentation with severe‐critical disease was higher in the older CKD and HD groups (43.6%, 55.3% and 16.1%, respectively). Among older patients, the intensive care unit (ICU) admission rate was significantly higher in the CKD and HD groups than in the control group (38.8%, 37.3% and 15.7%, respectively). In‐hospital mortality or death and/or ICU admission rates in the older group were significantly higher in the CKD (29.3% and 39.4%) and HD groups (26.7% and 30.1%) compared with the control group (8.6% and 17.1%). In the multivariate analysis, in‐hospital mortality rates in CKD and HD groups were higher than control group [hazard ratio (HR): 4.33 (95% confidence interval [CI]: 1.53‐12.26) and HR: 3.09 (95% CI: 1.04‐9.17), respectively]. Conclusion Among older COVID‐19 patients, in‐hospital mortality is significantly higher in those with stage 3‐5 CKD and on maintenance HD than older patients without CKD regardless of demographic characteristics, co‐morbidities, clinical and laboratory data on admission.

Published
2021

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