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Objective: Early triage of patients with coronavirus disease 2019 (COVID-19) is pivotal in managing the disease. However, studies on the clinical risk score system of the risk factors for the development of severe disease are limited. Hence, we conducted a clinical risk score system for severe illness, which might optimize appropriate treatment strategies., Methods: We conducted a retrospective, single-center study at the JinYinTan Hospital from January 24, 2020 to March 31, 2020. We evaluated the demographic, clinical, and laboratory data and performed a 10-fold cross-validation to split the data into a training set and validation set. We then screened the prognostic factors for severe illness using the least absolute shrinkage and selection operator (LASSO) and logistic regression, and finally conducted a risk score to estimate the probability of severe illness in the training set. Data from the validation set were used to validate the score., Results: A total of 295 patients were included. From 49 potential risk factors, 3 variables were measured as the risk score: neutrophil to lymphocyte ratio ( OR , 1.27; 95% CI , 1.15-1.39), albumin ( OR , 0.76; 95% CI , 0.70-0.83), and chest computed tomography abnormalities ( OR , 2.01; 95% CI , 1.41-2.86) and the AUC of the validation cohort was 0.822 (95% CI , 0.7667-0.8776)., Conclusion: This report may help define the potential of developing severe illness in patients with COVID-19 at an early stage, which might be related to the neutrophil to lymphocyte ratio, albumin, and chest computed tomography abnormalities., (Copyright © 2021 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.)

Porcine circovirus type 4 (PCV4) is a novel virus associated with porcine dermatitis and nephropathy syndrome (PDNS)-like signs identified firstly in China in 2019. However, the details of the molecular epidemiology of PCV4 are unclear at this time. A total of forty-two related sequences were selected from the GenBank database to explore the spread of PCV4 and its rule in genetic evolution. Of the selected strains, 41 were from south China in 2019 to 2021 and the other was a foreign representative strain. Phylogenetic tree construction, nucleotide and amino acid (aa) sequence alignment, gene recombination and antigen structure prediction were performed on the collected sequences using bioinformatics softwares. The 42 PCV4 strains were divided into two subgenotypes: PCV4a (35/42) and PCV4b (7/42), according to the constructed genetic evolution tree. PCV4a is the main epidemic strain, and it can be further divided into two different gene clusters: PCV4a-1 (22/35) and PCV4a-2 (13/35). The pairwise comparison analysis showed that the complete genome sequence similarity of the 42 PCV4 strains ranged between 97.9% and 100%, and the aa sequences of the Cap proteins of 42 PCV4 strains had three major heterogenic or hypervariable regions—27–28, 96 and 212—all located near the antigenic epitope of the Cap protein. The results of this study can provide some basis for further studying the spread and epidemic growth of PCV4, and the prevention and control of PCV4 infection in China. [ABSTRACT FROM AUTHOR]

The Illinois Fire Service Institute (IFSI) Library provides fire and emergency library and information assistance and services to the Institute's instructional staff, students, Illinois fire departments and firefighters, and other fire/emergency-related users in the successful and effective performance of their jobs. In response to the COVID pandemic, IFSI Librarians have developed new services and resources to continue serving patrons. At the same time, new procedures and services were adopted. With the staff's return to the library's physical location, IFSI's Learning Resource and Research Center building, new COVID-19-related safety measures have been instituted. IFSI Librarians worked with IFSI staff to create the COVID-19 Archives Collection to preserve important documents about the pandemic as it occurs. The Library received grant awards respectively from IMLS and ALA. During the pandemic, the IFSI International Programs continued to provide information resources and access to international users. The Library organized online academic activities via Zoom on a variety of workshops, lectures, and discussions to ensure that users were able to receive enough resources to continue their study and research. [ABSTRACT FROM AUTHOR]