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Background: The cororavirus disease 19 (COVID-19) pandemic has strained intensive care unit (ICU) material and human resources to global crisis levels. The risks of staffing challenges and clinician exposure are of significant concern. One resource, telecritical care (TCC), has the potential to optimize efficiency, maximize safety, and improve quality of care provided amid large-scale disruptions, but its role in pandemic situations is only loosely defined. Planning and Preparation Phase: We propose strategic initiatives by which TCC may act as a force multiplier for pandemic preparedness in response to COVID-19, utilizing a tiered approach for increasing surge capacity needs. The goals involved usage of TCC to augment ICU capacity, optimize safety, minimize personal protective equipment (PPE) use, improve efficiencies, and enhance knowledge of managing pandemic response. Implementation Phase: A phased approach utilizing TCC would involve implementing remote capabilities across the enterprise to accomplish the goals outlined. The hardware and software needed for initial expansion to cover 275 beds included $956,670 for mobile carts and $173,106 for home workstations. Team role deployment and bedside clinical care centering around TCC as critical care capacity expand beyond 275 beds. Surge capacity was not reached during early phases of the pandemic in the region, allowing refinement of TCC during subsequent pandemic phases. Conclusions: Leveraging TCC facilitated pandemic surge planning but required redefinition of typical ICU staffing models. The design was meant to workforce efficiencies, reduce PPE use, and minimize health care worker exposure risk, all while maintaining quality care standards through an intensivist-led model. As health care operations resumed and states reopened, TCC is being used to support shifts in volume and critical care personnel during the pandemic evolution. The lessons applied may help health care systems through variable phases of the pandemic.

Background: The high frequency of aerosolizing procedures in the ICU, including endotracheal intubation, places clinical staff at elevated risk of contracting the 2019 coronavirus (COVID-19). Use of an intubation checklist can reduce exposure risk and thus acts as a potential safeguard. Specific, step-by-step guidance to perform safe endotracheal intubation in the setting of COVID-19 are limited. This article outlines the development and refinement of a COVID-19 intubation checklist and operational protocol for ICU staff at a single center in the United States., Methods: A standard pre-intubation checklist was adapted and refined by consensus using a multidisciplinary and iterative process, then distributed to local staff for clinical use. Subsequent mock intubation training sessions were held using the new checklist to ensure proficiency. Planned debriefing sessions helped identify several previously unanticipated issues, allowing for further refinement of the intubation checklist and inclusion of all stakeholders., Results: A COVID-19 intubation checklist helped optimize safety during a high-risk situation by minimizing aerosolization of secretions, the number of staff required in the room, the time spent in the room, and the frequency of donning/doffing personal protective equipment., Conclusions: We present a checklist for use during high-risk intubations of COVID-19 patients, which serves as a pragmatic bedside tool for clinicians. The process of checklist development may also serve as a model for facilities preparing their own pandemic protocols., Competing Interests: Dr Singh has disclosed relationships with Medtronic, and Somnoware Sleep Solutions. All other authors have disclosed no conflicts of interest., (Copyright © 2021 by Daedalus Enterprises.)

This study employs the Maximal Overlap Discrete Wavelet Transform technique to analyze the wavelet-based correlations between Bitcoin, bond markets, and thirteen sectoral stock indices in India over the period from 2017 to 2023, focusing on the comparison of pre-and post-COVID-19 pandemic effects. The aim is to investigate the dynamic interrelationships and to understand the impact of the COVID-19 pandemic on these financial assets. The study period is divided into pre-COVID-19 and post-COVID-19. Findings from the study reveal a minimal negative correlation between Bitcoin, bond markets, and the sectoral stock indices in the pre-COVID era, indicating a lack of significant interdependence among these assets. However, the scenario changes markedly in the post-COVID period, shifting towards a positive correlation. This shift suggests that the COVID-19 pandemic has altered the relationship dynamics, leading to a more interconnected financial environment where movements in Bitcoin have begun to show a significant positive correlation with the movements in bond and sectoral stock indices in India. The study contributes to the existing literature by providing empirical evidence of how external shocks, such as the COVID-19 pandemic, can influence the correlation patterns among different financial assets. It highlights the importance of considering the changing dynamics in financial market correlations for investors, policymakers, and researchers in portfolio diversification, risk management, and financial stability analysis. Further, it underscores the role of alternative investments like Bitcoin in the evolving market landscape, particularly in response to global crises.

This study employs the Maximal Overlap Discrete Wavelet Transform technique to analyze the wavelet-based correlations between Bitcoin, bond markets, and thirteen sectoral stock indices in India over the period from 2O17 to 2O23, focusing on the comparison of pre -and post-COVID-19 pandemic effects. The aim is to investigate the dynamic interrelationships and to understand the impact of the COVID - 19 pandemic on these financial assets. The study period is divided into pre-COVID-19 and post-COVID-19. Findings from the study reveal a minimal negative correlation between Bitcoin, bond markets, and the sectoral stock indices in the pre -COVID era, indicating a lack of significant interdependence among these assets. However, the scenario changes markedly in the post-COVID period, shifting towards a positive correlation. This shift suggests that the COVID-19 pandemic has altered the relationship dynamics, leading to a more interconnected financial environment where movements in Bitcoin have begun to show a significant positive correlation with the movements in bond and sectoral stock indices in India. The study contributes to the existing literature by providing empirical evidence of how external shocks, such as the COVID-19 pandemic, can influence the correlation patterns among different financial assets. It highlights the importance of considering the changing dynamics in financial market correlations for investors, policymakers, and researchers in portfolio diversification, risk management, and financial stability analysis. Further, it underscores the role of alternative investments like Bitcoin in the evolving market landscape, particularly in response to global crises. [ABSTRACT FROM AUTHOR]

Innumerable personages are associated with susceptibility to the COVID-19 pandemic viral infection evolution, which has globally overblown the healthcare facilities. Following the emergence of respiratory syndrome coronavirus, 2019-nCoV delineates as a third major emergence of a novel coronavirus. β-coronavirus having suspected origin from bat comprehend congestion of the respiratory system, indicating a worldwide life threat to around 235 million asthma patients' existents as per WHO records. This review aims to investigate the risk constituents involved in virus-induced asthma, its management and prevention, origin, and transmission of coronavirus, including the relationship between different CoV infections. This review culminated the role of cytokines and chemokines and others found in COVID-19 patients, which could directly or indirectly affect the smooth muscle contractility reasoned to promote asthma severity, but this still remains unknown. The research highlights how essential it is to regularly wash your hands and clean surfaces that are touched by your hands in order to prevent illness. Some pre-clinical data suggests the preferred use of a PDE4 inhibitor like Roflumilast in case of uncontrolled virus-induced asthma exacerbations. Although there is a lack of particular asthma management so far, that is why the rectification of the consequences can only be done by taking supportive treatment. [ABSTRACT FROM AUTHOR]

Background:The cororavirus disease 19 (COVID-19) pandemic has strained intensive care unit (ICU) material and human resources to global crisis levels. The risks of staffing challenges and clinician exposure are of significant concern. One resource, telecritical care (TCC), has the potential to optimize efficiency, maximize safety, and improve quality of care provided amid large-scale disruptions, but its role in pandemic situations is only loosely defined. Planning and Preparation Phase:We propose strategic initiatives by which TCC may act as a force multiplier for pandemic preparedness in response to COVID-19, utilizing a tiered approach for increasing surge capacity needs. The goals involved usage of TCC to augment ICU capacity, optimize safety, minimize personal protective equipment (PPE) use, improve efficiencies, and enhance knowledge of managing pandemic response. Implementation Phase:A phased approach utilizing TCC would involve implementing remote capabilities across the enterprise to accomplish the goals outlined. The hardware and software needed for initial expansion to cover 275 beds included $956,670 for mobile carts and $173,106 for home workstations. Team role deployment and bedside clinical care centering around TCC as critical care capacity expand beyond 275 beds. Surge capacity was not reached during early phases of the pandemic in the region, allowing refinement of TCC during subsequent pandemic phases. Conclusions:Leveraging TCC facilitated pandemic surge planning but required redefinition of typical ICU staffing models. The design was meant to workforce efficiencies, reduce PPE use, and minimize health care worker exposure risk, all while maintaining quality care standards through an intensivist-led model. As health care operations resumed and states reopened, TCC is being used to support shifts in volume and critical care personnel during the pandemic evolution. The lessons applied may help health care systems through variable phases of the pandemic. [ABSTRACT FROM AUTHOR]