1. Evaluation of anti-severe acute respiratory syndrome coronavirus 2 antibody levels in coronavirus disease breakthrough infection during immunosuppressive therapy in a patient with connective tissue disease-related interstitial lung disease.
- Author
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Wada TT, Yokota K, Sakai S, Soma M, Kajiyama H, Tarumoto N, Maesaki S, Maeda T, Nagata M, and Mimura T
- Subjects
- Male, Humans, Aged, COVID-19 Vaccines adverse effects, BNT162 Vaccine, Breakthrough Infections, Tacrolimus therapeutic use, SARS-CoV-2, Immunosuppression Therapy, Antibodies, Viral, Immunoglobulin G, COVID-19, Lung Diseases, Interstitial diagnosis, Lung Diseases, Interstitial etiology, Connective Tissue Diseases complications, Connective Tissue Diseases drug therapy
- Abstract
Herein, we report the case of a 67-year-old man with severe coronavirus disease (COVID-19) pneumonia and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine breakthrough infection during immunosuppressive therapy for connective tissue disease-related interstitial lung disease (CTD-ILD). The patient received glucocorticoids combined with tacrolimus as maintenance therapy. His serum anti-SARS-CoV-2-immunoglobulin G (IgG) antibody levels were extremely low at the onset of COVID-19 pneumonia, even after the second dose of SARS-CoV-2 mRNA vaccine (BNT162b2). After treatment for COVID-19 pneumonia, the levels of anti-SARS-CoV-2-IgG antibodies increased. These results indicated a lack of the ability to produce neutralising antibodies from immune cells despite the booster vaccination. Therefore, we suggest that advanced-age patients with CTD-ILD receiving immunosuppressive therapy with polypharmacy require consistent personal protection, vaccination of close caregivers, increased awareness, and booster vaccination. Moreover, we recommend that tacrolimus should be withdrawn for a while after vaccination under controlled conditions., (© Japan College of Rheumatology 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2023
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